Heart Failure Clinical Trial
The Regulation of Pulmonary Vascular Resistance in Patients With Heart Failure
Summary
Peripheral blood and blood following a pulmonary wedge pressure will be obtained from patients undergoing right heart catheterizations.
Full Description
It is well known that left sided heart disease can lead to pulmonary hypertension via a number of proposed mechanisms. The purpose in this study is to identify biomarkers in pulmonary hypertension to further understand the pathophysiology of this disease in patients with heart disease.Patients are recruited in the cardiac catheterization lab, which are undergoing right heart catheterization as per their plan of care established by their primary cardiologist. During the procedure, we will ask the performing cardiologist to obtain a blood sample of 40-50 milliliters from the catheter that they are using during the procedure. These blood samples will be sent for analysis of biomarkers. The patient will then have an echocardiogram done 1 year from their heart catheterization.
Eligibility Criteria
Inclusion Criteria:
Age >18 years
Ability to provide informed consent.
Presenting for cardiac catheterization for evaluation of heart disease
Ejection Fraction > 50%
Exclusion Criteria:
Unable to provide informed consent.
Unable or unwilling to comply with the protocol and follow up.
Infiltrative cardiomyopathy
Constrictive pericarditis
Severe valvular disease
Comorbid status with life expectancy <3 years
Right ventricular dysplasia
Congenital heart disease
On immunosuppressive drugs.
Patients who has heart transplant.
Ejection Fraction < 50%
Mean Pulmonary Artery Pressure <25
Wedge pressure <15
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There is 1 Location for this study
Toledo Ohio, 43606, United States
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