Heart Failure Clinical Trial

The Safety and Efficacy of Adjunct Carvedilol in Children With Moderate Heart Failure

Summary

We would like to see if using Carvedilol in adjunct with Ace inhibitors will increase ejection fraction of the heart under echo. All interpretation of data will be sent to Boston Children's Hospital to be reviewed, which is the primary research center in this study. There are 5 hospitals participating in this study. The population targeted are children with moderate heart failure and must be on Ace inhibitors at the time of enrollment. Our outcome after placing them on Carvedilol is to change their ejection fraction on echo. The patients will be seen every 1-2 weeks, while we will titrate their medication to a maintenance dose. Secondary outcome is to increase quality of life, exercise tolerance and decrease their symptom scores as noted on their questionnaires.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Etiology of heart failure in Group 1 or Group 2
Moderate heart failure as evidenced by ventricular shortening fraction <= standard deviations below the mean, or ejection fraction <= 40% d) documented shortening fraction or ejection fraction that meet criteria for greater than 3 months
Standard medical therapy include ACE inhibitors plus or minus diuretics plus or minus digoxin; all efforts will made to maximize therapy prior to entry. Medication doses must be stable for 3 months prior to entry
Willingness to comply with followup testing

Study is for people with:

Heart Failure

Phase:

Phase 1

Study ID:

NCT00004854

Recruitment Status:

Completed

Sponsor:

National Center for Research Resources (NCRR)

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There is 1 Location for this study

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Washington University School of Medicine
St. Louis Missouri, 63110, United States

How clear is this clinincal trial information?

Study is for people with:

Heart Failure

Phase:

Phase 1

Study ID:

NCT00004854

Recruitment Status:

Completed

Sponsor:


National Center for Research Resources (NCRR)

How clear is this clinincal trial information?

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