A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy Summary The purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM).
View Eligibility Criteria Eligibility Criteria Inclusion Criteria: Diagnosis of HCM consistent with current American College of Cardiology Foundation/American Heart Association and European Society of Cardiology guidelines: unexplained left-ventricular hypertrophy with non-dilated ventricular chambers in the absence of other cardiac or systemic disease which can produce the required magnitude of hypertrophy of a maximal left ventricular (LV) wall thickness ≥ 15 millimeters (mm) (or ≥ 13 mm with positive family history of hypertrophic cardiomyopathy [HCM]) as determined by core laboratory interpretation Peak left ventricular outflow tract (LVOT) pressure gradient < 30 millimeters mercury (mm Hg) at rest and < 50 mm Hg with provocation (Valsalva maneuver and stress echocardiography) New York Heart Association (NYHA) Class II or III Exclusion Criteria: Known infiltrative or storage disorder causing cardiac hypertrophy that mimics non-obstructive hypertrophic cardiomyopathy (nHCM) such as Fabry disease, amyloidosis, or Noonan syndrome with LV hypertrophy History of unexplained syncope within 6 months prior to screening History of sustained ventricular tachyarrhythmia (> 30 seconds) within 6 months prior to screening Additional inclusion and exclusion criteria apply.
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There are 197 Locations for this study
UAB Hospital Clinical Research Unit Birmingham Alabama, 35233, United States
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Mayo Clinic Arizona - PPDS Phoenix Arizona, 85054, United States
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Sulpizio Cardiovascular Center La Jolla California, 92037, United States
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Cedars-Sinai Heart Institute Los Angeles California, 90048, United States
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Stanford University Palo Alto California, 94304, United States
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UCSF School of Medicine San Francisco California, 94143, United States
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University of Florida Gainesville Florida, 32610, United States
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Usf Health South Tampa Center For Advanced Healthcare Tampa Florida, 33606, United States
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Emory University Hospital Atlanta Georgia, 30322, United States
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Indiana University School of Medicine-Indianapolis Indianapolis Indiana, 46202, United States
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University of Iowa Hospitals And Clinics Iowa City Iowa, 52242, United States
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University of Kansas Medical Center Kansas City Kansas, 66160, United States
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Norton Healthcare Louisville Kentucky, 40217, United States
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Johns Hopkins University Baltimore Maryland, 21287, United States
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Massachusetts General Hospital Boston Massachusetts, 02114, United States
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University of Michigan Comprehensive Cancer Center UMCCC-Gastrointestinal Cancer Clinic Ann Arbor Michigan, 48109, United States
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Henry Ford Hospital Detroit Michigan, 48202, United States
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Spectrum Health Grand Rapids Michigan, 49525, United States
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Mayo Clinic - PPDS Rochester Minnesota, 55905, United States
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Washington University School of Medicine Saint Louis Missouri, 63110, United States
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University of Nebraska Medical Center Omaha Nebraska, 68198, United States
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North Shore University Hospital-300 Community Dr Manhasset New York, 11030, United States
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Stony Brook Heart Institute Stony Brook New York, 11790, United States
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Westchester Medical Center Valhalla New York, 10595, United States
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Carolinas Healthcare System Charlotte North Carolina, 28402, United States
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Duke University Health System Durham North Carolina, 27710, United States
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Cleveland Clinic Ohio - 9500 Euclid Ave Cleveland Ohio, 44195, United States
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Oregon Health and Science University Portland Oregon, 97239, United States
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St. Luke's University Health Network Allentown Pennsylvania, 18104, United States
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Penn State Health Milton S. Hershey Medical Center Hershey Pennsylvania, 17033, United States
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Lancaster General Hospital Lancaster Pennsylvania, 17604, United States
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University of Pennsylvania Philadelphia Pennsylvania, 19104, United States
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University of Pittsburgh Medical Center Pittsburgh Pennsylvania, 15213, United States
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Medical University of South Carolina - PPDS Charleston South Carolina, 29425, United States
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Stern Cardiovascular Center. Pa Germantown Tennessee, 38138, United States
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Baylor Heart and Vascular Hospital Dallas Texas, 75226, United States
University of Texas Southwestern Medical Center Dallas Texas, 75390, United States
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University of Texam Houston Medical School Houston Texas, 77030, United States
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Baylor Scott and White Research Institute Temple Texas, 76508, United States
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University of Utah - PPDS Salt Lake City Utah, 84132, United States
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University of Virginia Health System Charlottesville Virginia, 22908, United States
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Virginia Commonwealth University Medical Center Richmond Virginia, 23298, United States
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University of Washington Medical Center Seattle Washington, 98195, United States
Local Institution - 0063 Concord New South Wales, 2139, Australia
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Local Institution - 0085 Darlinghurst New South Wales, 2010, Australia
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Local Institution - 0369 Liverpool New South Wales, 2170, Australia
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Local Institution - 0357 Wagga Wagga New South Wales, 2650, Australia
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Local Institution - 0080 Chermside Queensland, 4032, Australia
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Local Institution - 0078 Milton Queensland, 4064, Australia
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Local Institution - 0050 Bedford Park South Australia, 5042, Australia
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Local Institution - 0076 Murdoch Western Australia, 6150, Australia
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Local Institution - 0069 Braunau am Inn Oberösterreich, 5280, Austria
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Local Institution - 0062 Graz Steiermark, 8010, Austria
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Local Institution - 0090 Innsbruck Tirol, 6020, Austria
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Local Institution - 0075 Linz , 4020, Austria
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Local Institution - 0429 Wien , 1090, Austria
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Local Institution - 0462 Edegem Antwerpen, 2650, Belgium
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Local Institution - 0034 Anderlecht Brussels, 1070, Belgium
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Local Institution - 0476 Genk Limburg, 3600, Belgium
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Local Institution - 0319 Leuven Vlaams Brabant, 3000, Belgium
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Local Institution - 0413 Salvador Bahia, 40170, Brazil
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Local Institution - 0437 Fortaleza Ceara, 60430, Brazil
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Local Institution - 0438 Brasília Distrito Federal, 70710, Brazil
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Local Institution - 0459 Goiânia Goias, 74223, Brazil
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Local Institution - 0425 Belo Horizonte Minas Gerais, 30110, Brazil
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Local Institution - 0447 Porto Alegre RIO Grande DO SUL, 90560, Brazil
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Local Institution - 0450 Porto Alegre RIO Grande DO SUL, 90620, Brazil
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Local Institution - 0430 Bragança Paulista SAO Paulo, 12916, Brazil
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Local Institution - 0422 Ribeirão Preto SAO Paulo, 14026, Brazil
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Local Institution - 0418 São Paulo SAO Paulo, 04012, Brazil
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Local Institution - 0412 São Paulo SAO Paulo, 05403, Brazil
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Local Institution - 0446 Rio De Janeiro , 20551, Brazil
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Local Institution - 0451 Rio de Janeiro , 22061, Brazil
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Local Institution - 0381 Calgary Alberta, T2N 1, Canada
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Local Institution - 0467 Vancouver British Columbia, V6E 1, Canada
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Local Institution - 0414 Hamilton Ontario, L8L 2, Canada
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Local Institution - 0470 Montreal Quebec, H1T 1, Canada
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Local Institution - 0093 Quebec , G1V 4, Canada
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Local Institution - 0188 Brno Jihomoravský Kraj, 656 9, Czechia
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Local Institution - 0086 Broumov Královéhradecký Kraj, 550 0, Czechia
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Local Institution - 0033 Prague Praha, Hlavní Mesto, 140 0, Czechia
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Local Institution - 0052 Praha 2 , 128 0, Czechia
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Local Institution - 0045 Aalborg Nordjylland, 9000, Denmark
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Local Institution - 0428 Aabenraa South Denmark, 6200, Denmark
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Local Institution - 0019 Aarhus N , 8200, Denmark
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Local Institution - 0001 Nice Alpes-Maritimes, 06000, France
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Local Institution - 0463 Brest Finistère, 29200, France
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Local Institution - 0053 Pessac Gironde, 33600, France
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Local Institution - 0005 Toulouse Haute-Garonne, 31000, France
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Local Institution - 0221 Boulogne-Billancourt Hauts-de-Seine, 92100, France
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Local Institution - 0003 Chambray-lès-tours Indre-et-Loire, 37044, France
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Local Institution - 0067 Bron Rhône, 69500, France
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Local Institution - 0009 Nantes , 44000, France
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Local Institution - 0004 Paris , 75013, France
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Local Institution - 0008 Rennes , 35000, France
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Local Institution - 0022 München Bayern, 81377, Germany
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Local Institution - 0440 Regensburg Bayern, 93053, Germany
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Local Institution - 0258 Würzburg Bayern, 97078, Germany
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Local Institution - 0168 Hamamatsu-Shi Shizuoka, 431-3, Japan
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Local Institution - 0443 Lørenskog Akershus, N-147, Norway
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Local Institution - 0044 Guimarães Braga, 4835-, Portugal
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Local Institution - 0299 L'hospitalet de Llobregat Barcelona, 08907, Spain
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Local Institution - 0041 Malaga Málaga, 29010, Spain
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Local Institution - 0087 Alicante , 03010, Spain
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Local Institution - 0018 Barcelona , 08035, Spain
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Local Institution - 0237 Murcia , 30120, Spain
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Local Institution - 0031 Salamanca , 37007, Spain
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Local Institution - 0051 Sevilla , 41009, Spain
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Local Institution - 0027 Valencia , 46026, Spain
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Local Institution - 0445 London Greater London, SW3 6, United Kingdom
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Local Institution - 0073 Glasgow Lanarkshire, G51 4, United Kingdom
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Local Institution - 0472 London Middlesex, EC1A , United Kingdom
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Local Institution - 0407 Birmingham , B15 2, United Kingdom
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