Hypertrophic Cardiomyopathy Clinical Trial
A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy
Summary
The purpose of this study is to evaluate the mavacamten impact on myocardial structure with cardiac magnetic resonance imaging (CMR) in adult participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) [New York Heart Association (NYHA) Functional Class II or III].
Eligibility Criteria
Inclusion Criteria:
Diagnosed with obstructive hypertrophic cardiomyopathy (oHCM), in accordance with current American College of Cardiology Foundation/American Heart Association and European Society of Cardiology guidelines as below:
Left ventricular outflow tract (LVOT) peak gradient ≥ 30 mm Hg and ≥ 50 mm Hg after Valsalva or after exercise
Left ventricular ejection fraction (LVEF) ≥ 55% at rest
New York Heart Association (NYHA) functional class II or III symptoms
Exclusion Criteria:
A known infiltrative or storage disorder causing cardiac hypertrophy that mimics oHCM
Documented obstructive coronary artery disease or history of myocardial infarction
A history of resuscitated sudden cardiac arrest or life-threatening ventricular arrhythmia within 6 months prior to screening
An implantable cardioverter defibrillator (ICD) or pacemaker, or another contraindication for cardiac magnetic resonance imaging (CMR)
Note: Other protocol-defined inclusion/exclusion criteria apply
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There are 16 Locations for this study
Cleveland Ohio, 44106, United States More Info
Darlinghurst New South Wales, 2010, Australia
Calgary Alberta, T2N 1, Canada
Prague Praha, Hlavní Mesto, 140 2, Czechia
Bern , 3010, Switzerland
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