Hypertrophic Cardiomyopathy Clinical Trial

Clinical Trial Finder Hypertrophic Cardiomyopathy Trials

A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy

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Summary

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of mavacamten in adolescent patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM).

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Eligibility Criteria

Inclusion Criteria:

Diagnosis of HCM
Presence of LVOT obstruction
Presence of symptoms

Exclusion Criteria:

Phenocopy diseases resulting in myocardial hypertrophy not related to sarcomere dysfunction
Evidence of LVEF <50% in prior 6 months
Planned escalation in HCM therapy or upcoming intervention (eg, major cardiac surgery, HCM medication dose increase)

Other protocol-defined Inclusion/Exclusion criteria apply.

Study is for people with:

Hypertrophic Cardiomyopathy

Phase:

Phase 3

Estimated Enrollment:

40

Study ID:

NCT06253221

Recruitment Status:

Recruiting

Sponsor:

Bristol-Myers Squibb

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There are 54 Locations for this study

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Local Institution - 0017
Birmingham Alabama, 35294, United States More Info
Site 0017
Contact
Local Institution - 0050
Phoenix Arizona, 85016, United States More Info
Site 0050
Contact
Local Institution - 0032
Los Angeles California, 90027, United States More Info
Site 0032
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Local Institution - 0008
Los Angeles California, 90095, United States More Info
Site 0008
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Local Institution - 0004
Oakland California, 94609, United States More Info
Site 0004
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Local Institution - 0033
Palo Alto California, 94304, United States More Info
Site 0033
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Local Institution - 0044
San Diego California, 92123, United States More Info
Site 0044
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Local Institution - 0038
Aurora Colorado, 80045, United States More Info
Site 0038
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Local Institution - 0031
Saint Petersburg Florida, 33701, United States More Info
Site 0031
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Local Institution - 0053
Atlanta Georgia, 30322, United States More Info
Site 0053
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Local Institution - 0013
Chicago Illinois, 60637, United States More Info
Site 0013
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Riley Hospital for Children - Pediatric Cardiology
Indianapolis Indiana, 46202, United States More Info
John Parent, Site 0009
Contact
317-908-4944
Local Institution - 0043
Boston Massachusetts, 02115, United States More Info
Site 0043
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University of Michigan - C.S. Mott Children's Hospital
Ann Arbor Michigan, 48109, United States More Info
Mark Russell, Site 0002
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734-660-3431
Local Institution - 0037
Saint Louis Missouri, 63110, United States More Info
Site 0037
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Local Institution - 0052
Morristown New Jersey, 07960, United States More Info
Site 0052
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Local Institution - 0040
Bronx New York, 10467, United States More Info
Site 0040
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Cohen Children's Medical Center of New York
New Hyde Park New York, 11042, United States More Info
Jeffrey Gossett, Site 0010
Contact
516-601-7291
Local Institution - 0024
New York New York, 10029, United States More Info
Site 0024
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Local Institution - 0036
New York New York, 10032, United States More Info
Site 0036
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Local Institution - 0015
Charlotte North Carolina, 28204, United States More Info
Site 0015
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Local Institution - 0039
Durham North Carolina, 27705, United States More Info
Site 0039
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Local Institution - 0019
Cincinnati Ohio, 45229, United States More Info
Site 0019
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Local Institution - 0001
Cleveland Ohio, 44195, United States More Info
Site 0001
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Local Institution - 0029
Columbus Ohio, 43205, United States More Info
Site 0029
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Local Institution - 0030
Philadelphia Pennsylvania, 19104, United States More Info
Site 0030
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Local Institution - 0005
Pittsburgh Pennsylvania, 15224, United States More Info
Site 0005
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Local Institution - 0034
Memphis Tennessee, 38104, United States More Info
Site 0034
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Local Institution - 0045
Austin Texas, 78712, United States More Info
Site 0045
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Local Institution - 0054
Houston Texas, 77030, United States More Info
Site 0054
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Local Institution - 0003
Salt Lake City Utah, 84113, United States More Info
Site 0003
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Local Institution - 0012
Charlottesville Virginia, 22908, United States More Info
Site 0012
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Local Institution - 0035
Madison Wisconsin, 53792, United States More Info
Site 0035
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Local Institution - 0020
Sydney New South Wales, 2145, Australia More Info
Site 0020
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Local Institution - 0042
Clayton Victoria, 3168, Australia More Info
Site 0042
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Local Institution - 0028
Parkville Victoria, 3052, Australia
Local Institution - 0041
Edmonton Alberta, T6G 2, Canada More Info
Site 0041
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Local Institution - 0046
Toronto Ontario, M5G 1, Canada More Info
Site 0046
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Local Institution - 0022
Paris , 75015, France More Info
Site 0022
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Local Institution - 0026
Pessac , 33604, France More Info
Site 0026
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Local Institution - 0018
Berlin BE, 13353, Germany More Info
Site 0018
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Local Institution - 0006
Munich BY, 80636, Germany More Info
Site 0006
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Local Institution - 0047
Drimnagh D, D12 V, Ireland More Info
Site 0047
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Local Institution - 0016
Firenze FI, 50100, Italy More Info
Site 0016
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Local Institution - 0051
Genova GE, 16147, Italy More Info
Site 0051
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Local Institution - 0027
Napoli , 80131, Italy More Info
Site 0027
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Local Institution - 0014
Barcelona B, 8950, Spain More Info
Site 0014
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Local Institution - 0021
Granada GR, 18014, Spain
Local Institution - 0048
Madrid M, 28007, Spain More Info
Site 0048
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Local Institution - 0011
A Coruna , 15009, Spain
Local Institution - 0023
Madrid , 28041, Spain
Local Institution - 0025
Madrid , 28046, Spain More Info
Site 0025
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Local Institution - 0049
Belfast BFS, BT12 , United Kingdom More Info
Site 0049
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Local Institution - 0007
London , WC1N , United Kingdom More Info
Site 0007
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How clear is this clinincal trial information?

Study is for people with:

Hypertrophic Cardiomyopathy

Phase:

Phase 3

Estimated Enrollment:

40

Study ID:

NCT06253221

Recruitment Status:

Recruiting

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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