Kidney Cancer Clinical Trial

NM32-2668 in Adult Patients With Selected Advanced Solid Tumors

Summary

This is a first-in-human, open-label, multi-center, Phase 1, dose-escalation study with expansion cohorts to evaluate NM32-2668 for safety and immunogenicity, to determine the maximal tolerated dose and recommended Phase 2 dose, define the pharmacokinetics, to explore the pharmacodynamics, and to obtain preliminary evidence of the clinical activity in adult patients with selected advanced solid tumors.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patients with histologically confirmed, advanced-stage protocol-specified solid tumors.
Confirmed ROR1 tumor expression.
Patients who have undergone at least one prior systemic therapy and have radiologically or clinically determined progressive disease during or after most recent line of therapy, and for whom no further standard therapy is available, or who are intolerable or have medical contraindications to standard therapy.

Exclusion Criteria:

Prior treatment with any agent targeting ROR1 or prior treatment with a CD3 T-cell engaging therapy.
Prior treatment with chimeric antigen receptor (CAR) cell therapy within 90 days prior to first dose of NM32-2668.
Systemic anti-neoplastic therapy within five half-lives or 21 days, whichever is shorter, prior to first dose of NM32-2668.
Wide-field radiotherapy (> 30% of marrow-bearing bones) within 28 days, or focal radiation for analgesic purpose or for lytic lesions at risk of fracture within 14 days prior to first dose of NM32-2668, or no recovery from side effects of such prior interventions.

Study is for people with:

Kidney Cancer

Phase:

Phase 1

Estimated Enrollment:

180

Study ID:

NCT06299163

Recruitment Status:

Recruiting

Sponsor:

Numab Therapeutics AG

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There are 2 Locations for this study

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Lifespan Cancer Institute at Rhode Island Hospital
Providence Rhode Island, 02903, United States More Info
Benedito A. Carneiro, MD
Contact
Benedito A. Carneiro, MD
Principal Investigator
Mary Crowley Cancer Research
Dallas Texas, 75230, United States More Info
Douglas W. Orr, MD
Contact
Douglas W. Orr, MD
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Kidney Cancer

Phase:

Phase 1

Estimated Enrollment:

180

Study ID:

NCT06299163

Recruitment Status:

Recruiting

Sponsor:


Numab Therapeutics AG

How clear is this clinincal trial information?

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