Study of Efficacy, Safety, and Quality of Life of Pazopanib in Patients With Advanced and/or Metastatic Renal Cell Carcinoma After Prior Checkpoint Inhibitor Treatment

Key Inclusion Criteria:

Histologically confirmed locally recurrent or metastatic predominantly clear cell renal cell carcinoma.
Measurable disease based on RECIST 1.1 criteria
Prior systemic therapy with an immune checkpoint inhibitor (monotherapy or combination) as 1st or 2nd line RCC treatment. Note: patients with prior mTOR inhibitor or TKI treatment as monotherapy or in combination with immune checkpoint inhibitor were allowed; however, treatment with immune checkpoint inhibitor (monotherapy or in combination) must have been the last treatment prior to study entry.
Last dose of immune checkpoint inhibitor therapy received 4 or more weeks before start of study treatment
Karnofsky performance status ≥70%.
Potassium, sodium, calcium and magnesium within normal limits of the central laboratory

Key Exclusion Criteria:

Renal cell carcinoma without any clear (conventional) cell component
History or evidence of central nervous system (CNS) metastases (patients with pretreated metastases were eligible under certain conditions)
Prior treatment with pazopanib
Prior treatment with bevacizumab that was not given in combination with immune checkpoint inhibitor therapy.
Prior treatment with more than 2 lines of therapy (combination treatments were considered 1 line of therapy)
Not recovered from toxicity from prior immune checkpoint inhibitor therapy. Recovery was defined as ≤ NCI-CTCAE Grade 1, except for liver function test levels which must be Disease recurrence less than 6 months from the last dose of prior neoadjuvant or adjuvant therapy (including VEGF-R TKI)
Patients receiving prohibited concomitant medications that could not be discontinued or replaced by safe alternative medication at least 5 half-lives of the concomitant medication or 7 days, whichever was longer, prior to the start of pazopanib treatment.
Administration of any investigational drug within 4 weeks prior to the first dose of study treatment