A Proof of Principle Study of Aminolevulinic Acid (ALA) – Induced Fluorescence Detection in Resectable Non-Small Cell Lung Cancer

Inclusion Criteria:

Inclusion Criteria Patients (12 total patients with lung cancer) meeting eligibility criteria will be enrolled.
Preoperative diagnosis of either presumed or documented non-small cell lung cancer.
Tumor judged to be suitable for surgical resection based on preoperative evaluation of radiographic studies, pulmonary function tests, performance status and clinical judgment of surgeons at DHMC (Erkmen, Nugent)
Age ≥ 18 years old.
Population representative of our usual referral pattern including minority populations, women and those who are financially disadvantaged.
Subjects capable of giving informed consent

Exclusion Criteria:

Pregnant Women
Women who are breast feeding
History of cutaneous photosensitivity
Porphyria, hypersensitivity to porphyrins, photodermatosis
Exfoliative dermatitis
History of liver disease within the last 12 months
Inability to comply with photosensitivity precautions associated with the study
Inability to give informed consent
AST, ALT, ALP or bilirubin levels greater than 2.5 times the normal limit at any time during the past 2 months
Plasma creatinine in excess of 180 umol/L
Women who are breast feeding
History of cutaneous photosensitivity
Porphyria, hypersensitivity to porphyrins, photodermatosis
Exfoliative dermatitis
History of liver disease within the last 12 months
Inability to comply with photosensitivity precautions associated with the study