Lung Cancer Clinical Trial

A Study of Atezolizumab as Neoadjuvant and Adjuvant Therapy in Resectable Non-Small Cell Lung Cancer (NSCLC) – Lung Cancer Mutation Consortium (LCMC3)

Summary

This study was designed to evaluate the safety and efficacy of neoadjuvant and adjuvant atezolizumab in participants with resectable Non-Small Cell Lung Cancer (NSCLC). Neoadjuvant therapy consisted of two 21-day cycles with atezolizumab. Following surgery, adjuvant therapy consisted of up to 12 months of atezolizumab in participants who demonstrate clinical benefit with neoadjuvant therapy. All participants who undergo surgery entered a surveillance period, which consisted of standardized blood sample collection and Chest CT Scans, for up to 2 years. All participants were monitored for disease recurrence and survival for up to 3 years after last dose of study drug.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Pathologically documented Stage IB, II, IIIA, or selected IIIB, including T3N2 or T4 (by size criteria, not by mediastinal invasion) NSCLC
Adequate pulmonary and cardiac function
Available biopsy of primary tumor with adequate samples
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

Exclusion Criteria:

NSCLC that is clinically T4 by virtue of mediastinal organ invasion or Stage IIIB by virtue of N3 disease
Any prior therapy for lung cancer within 3 years.
Prior treatment with anti-PD-1 or PD-L1 therapies
History or risk of autoimmune disease

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

181

Study ID:

NCT02927301

Recruitment Status:

Completed

Sponsor:

Genentech, Inc.

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There are 20 Locations for this study

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City of Hope Comprehensive Cancer Center
Duarte California, 91010, United States
UCLA Cancer Center
Santa Monica California, 90404, United States
University Of Colorado
Aurora Colorado, 80045, United States
Yale Cancer Center
New Haven Connecticut, 06520, United States
Moffitt Cancer Center
Tampa Florida, 33612, United States
Emory University; Winship Cancer Institute
Atlanta Georgia, 30308, United States
Dana Farber Cancer Institute; Brigham and Womens Hospital
Boston Massachusetts, 02115, United States
Mass General/North Shore Cancer
Danvers Massachusetts, 01923, United States
Karmanos Cancer Inst; Hematology/Oncology
Detroit Michigan, 48201, United States
Washington University; Wash Uni. Sch. Of Med
Saint Louis Missouri, 63110, United States
Dartmouth Hitchcock Medical Center
Lebanon New Hampshire, 03756, United States
Memorial Sloan Kettering - Monmouth
Middletown New Jersey, 07748, United States
Memorial Sloan Kettering Bergen
Montvale New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center - Commack
Commack New York, 11725, United States
Memorial Sloan Kettering Cancer Center at Westchester
Harrison New York, 10604, United States
Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center - Koch
New York New York, 10021, United States
New York University Medical Center
New York New York, 10036, United States
Memorial Sloan Kettering - Basking Ridge
New York New York, 10065, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States
Memorial Sloan Kettering Nassau
Uniondale New York, 11553, United States
The Ohio State University Comprehensive Cancer Center
Columbus Ohio, 43210, United States

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

181

Study ID:

NCT02927301

Recruitment Status:

Completed

Sponsor:


Genentech, Inc.

How clear is this clinincal trial information?

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