The purpose of this study is to evaluate BMS-986442 in combination with nivolumab (with or without chemotherapy) for its antitumor efficacy and benefit to participants.
Participants in all parts of the study must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. Participants must have a life expectancy of at least 3 months at the time of first dose.
Exclusion Criteria:
Untreated symptomatic central nervous system metastases or leptomeningeal metastases. Concurrent malignancy (present during screening) requiring treatment, or history of prior malignancy active within 2 years prior to randomization in study Part B1 or treatment assignment in all other study parts. Participants with an active, known, or suspected autoimmune disease.
Other protocol-defined inclusion/exclusion criteria apply.