Lung Cancer Clinical Trial

A Study to Evaluate Immunotherapy Combinations in Participants With Lung Cancer

Summary

This is a Phase 1/1b, multicenter, open-label, dose-escalation and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic, and clinical activity of etrumadenant (AB928) in combination with carboplatin and pemetrexed, with or without an anti-PD-1 antibody (pembrolizumab or zimberelimab), in participants with non-squamous Non-Small Cell Lung Cancer (NSCLC).

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Full Description

In the dose-escalation phase, escalating doses of etrumadenant in combination with carboplatin and pemetrexed at standard doses (Arm A), and etrumadenant in combination with carboplatin, pemetrexed and pembrolizumab (Arm B), may be assessed in participants with advanced NSCLC. Eligible participants will receive oral administration of etrumadenant as well as IV infused carboplatin, pemetrexed, with or without pembrolizumab in this phase. The recommended dose for expansion (RDE) of etrumadenant will be determined upon completion of the dose-escalation phase.

In the dose-expansion phase, zimberelimab in combination with carboplatin and pemetrexed (Arm 1), and etrumadenant at RDE in combination with carboplatin, pemetrexed, and zimberelimab (Arm 2) may be assessed in eligible NSCLC participants who harbor an EGFR mutation and have progressed on EGFR Tyrosine Kinase Inhibitor (TKI) treatment(s).

Overall duration of treatment will depend on how well the treatment is tolerated.

Treatment may continue until unacceptable toxicity or progressive disease or other reasons specified in the protocol.

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Eligibility Criteria

Inclusion Criteria:

Male or female participants; age ≥ 18 years
Pathologically confirmed nonsquamous NSCLC that is metastatic, locally advanced, or recurrent with progression

Arm A participants must fulfill one of the following:

Participant has a genetic alteration (mutation or rearrangement) and has received all available targeted therapy. Previous treatment with chemotherapy or PD-1/-L1 therapy is not allowed.
Participant has not received any therapy for the disease under study and standard therapy is refused.
Participant has progressed on PD-1/-L1 therapy (monotherapy or combination regimen). Previous treatment with chemotherapy is not allowed.
Participant has progressed on PD-1/-L1 therapy (monotherapy or combination regimen) and has received less than 4 cycles of carboplatin/pemetrexed and further chemotherapy is appropriate.
Participant has received any number of prior treatments and is without alternative or curative therapy.

Arm B participants must fulfill one of the following:

Participant has a genetic alteration (mutation or rearrangement) and has received all available targeted therapy. Previous treatment with chemotherapy or PD-1/-L1 therapy is not allowed.
Participant has not received any therapy for the disease under study and standard therapy is refused.
Participant has received any number of prior treatments and is without alternative or curative therapy.
Arm 1 and Arm 2 participants must have a sensitizing epidermal growth factor receptor (EGFR) mutation with disease progression or treatment intolerance after one or more approved TKIs. Previous treatment with chemotherapy or PD-1/L-1 therapy is not allowed.
No TKI therapy within 5 days of Cycle 1 Day 1
The last dose of previous investigational therapy is at least 4 weeks or 5 half-lives prior to Cycle 1 Day 1.
Must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST v1.1)
Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.
Confirm that an archival tissue sample is available and ≤ 24 months old; if not, a new biopsy of a tumor lesion should be obtained at screening
Adequate organ and marrow function

Exclusion Criteria:

Use of any live vaccines against infectious diseases within 4 weeks (28 days) of initiation of investigational product
Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the pre-screening or screening visit through 30 days after the last dose of etrumadenant, 90 days after the last dose of zimberelimab or pembrolizumab, or 6 months after the last dose of pemetrexed, whichever is longer
Any active autoimmune disease or a documented history of autoimmune disease or syndrome that required systemic treatment in the past 2 years (ie, with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs), except for vitiligo or resolved childhood asthma/atopy
Prior malignancy active within the previous 2 years except for locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix, breast, or prostate cancer
Prior use of an adenosine pathway targeting agent

Due to potential for drug-drug interactions with etrumadenant, participants must not have had:

Treatment with breast cancer resistance protein substrates or P-glycoprotein with a narrow therapeutic window, administered orally within 4 weeks or 5 half-lives of the drug (whichever is longer) prior to initiation of study treatment.
Treatment with known strong cytochrome P450 3A4 (CYP3A4) inducers and strong CYP3A4 inhibitors within 4 weeks or 5 half-lives of the drug (whichever is longer) prior to initiation of study treatment

Study is for people with:

Lung Cancer

Phase:

Phase 1

Estimated Enrollment:

77

Study ID:

NCT03846310

Recruitment Status:

Active, not recruiting

Sponsor:

Arcus Biosciences, Inc.

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There are 22 Locations for this study

See Locations Near You

Arizona Clinical Research Center
Tucson Arizona, 85715, United States
Florida Cancer Specialists - South
Fort Myers Florida, 33901, United States
Florida Cancer Specialists & Research Institute
Tavares Florida, 33705, United States
Tennessee Oncology
Nashville Tennessee, 37203, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas Texas, 75246, United States
Virginia Cancer Specialists
Fairfax Virginia, 22031, United States
Virginia Oncology Associates
Norfolk Virginia, 23502, United States
Medical Oncology Associates, PS (dba Summit Cancer Centers)
Spokane Washington, 99208, United States
St Vincent Hospital of the Catholic University of Korea
Suwon-si Gyeonggi-do, 16247, Korea, Republic of
Chungbuk National University Hospital
Cheongju-si , 28644, Korea, Republic of
CHA Bundang Medical Center, CHA University
Seongnam-si , 13496, Korea, Republic of
Severance Hospital, Yonsei University Health System
Seoul , 03722, Korea, Republic of
Asan Medical Centre
Seoul , 05505, Korea, Republic of
Seoul St. Mary's Hospital, The Catholic University of Korea
Seoul , 06591, Korea, Republic of
Seoul National University Hospital
Suwon , 03080, Korea, Republic of
National University Hospital
Singapore , 11922, Singapore
National Cancer Centre Singapore
Singapore , 16961, Singapore
Changhua Christian Hospital
Changhua , 500, Taiwan
Taipei Medical University - Shuang Ho Hospital
New Taipei City , 23561, Taiwan
Chi Mei Hospital, Liouying
Tainan City , 73657, Taiwan
National Taiwan University Hospital
Taipei City , 10002, Taiwan
Tri-Service General Hospital
Taipei , 11490, Taiwan

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 1

Estimated Enrollment:

77

Study ID:

NCT03846310

Recruitment Status:

Active, not recruiting

Sponsor:


Arcus Biosciences, Inc.

How clear is this clinincal trial information?

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