Lung Cancer Clinical Trial

Clinical Trial Finder Lung Cancer Trials

An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)

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Summary

The purpose of this study is to show that Nivolumab, or Nivolumab plus Ipilimumab, or Nivolumab plus Platinum-Doublet Chemotherapy improves progression free survival and/or overall survival compared with chemotherapy in patients with advanced lung cancer.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Subjects with histologically confirmed Stage IV or recurrent NSCLC squamous or non-squamous histology, with no prior systemic anticancer therapy
Subjects must have programmed death-ligand 1 (PD -L1) immunohistochemical (IHC) testing, with results, performed by the central lab during the Screening period
Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1
Measurable disease by CT or MRI per response evaluation criteria in solid tumors version 1.1 (RECIST 1.1) criteria

Exclusion Criteria:

Subjects with untreated Central nervous system (CNS) metastases are excluded
Subjects with an active, known or suspected autoimmune disease are excluded
Any positive test for hepatitis B virus or hepatitis C virus or human immunodeficiency virus (HIV) indicating acute or chronic infection

Other protocol defined inclusion/exclusion criteria apply

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

2748

Study ID:

NCT02477826

Recruitment Status:

Active, not recruiting

Sponsor:

Bristol-Myers Squibb

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There are 268 Locations for this study

See Locations Near You

Southern Cancer Center, Inc.
Mobile Alabama, 36608, United States
California Pacific Medical Center
San Francisco California, 94115, United States
Local Institution - 0021
New Haven Connecticut, 06520, United States
Local Institution - 0001
Atlanta Georgia, 30322, United States
Local Institution - 0013
Marietta Georgia, 30060, United States
Local Institution - 0004
Lexington Kentucky, 40503, United States
Washington University School Of Medicine
Saint Louis Missouri, 63110, United States
Local Institution - 0005
Buffalo New York, 14263, United States
Local Institution - 0019
New York New York, 10065, United States
University Hospitals
Cleveland Ohio, 44106, United States
Local Institution - 0009
Columbus Ohio, 43210, United States
Local Institution - 0007
Allentown Pennsylvania, 18103, United States
St. Mary Medical Center
Langhorne Pennsylvania, 19047, United States
Local Institution - 0299
Philadelphia Pennsylvania, 19107, United States
Local Institution - 0012
Philadelphia Pennsylvania, 19111, United States
Local Institution - 0015
Sayre Pennsylvania, 18840, United States
Local Institution - 0008
Charleston South Carolina, 29425, United States
Local Institution - 0080
Greenville South Carolina, 29605, United States
Local Institution - 0010
Greenville South Carolina, 29607, United States
Local Institution - 0020
Nashville Tennessee, 37232, United States
Local Institution - 0306
Dallas Texas, 75390, United States
Local Institution - 0003
Dallas Texas, 75390, United States
Local Institution - 0102
Houston Texas, 77030, United States
Local Institution - 0011
Salt Lake City Utah, 84108, United States
Local Institution - 0074
Kennewick Washington, 99336, United States
Local Institution - 0170
Berazategui Buenos Aires, 1880, Argentina
Local Institution - 0171
Capital Federal Buenos Aires, 1426, Argentina
Local Institution - 0172
Ciudad Autonoma De Buenos Aire Buenos Aires, 1181, Argentina
Local Institution - 0176
Ciudad de Buenos Aires Buenos Aires, 1025, Argentina
Local Institution - 0296
Mar Del Plata Buenos Aires, 7600, Argentina
Local Institution - 0177
Viedma RIO Negro, 8500, Argentina
Local Institution - 0130
San Miguel de Tucuman Tucuman, 4000, Argentina
Local Institution - 0268
Cordoba , 5000, Argentina
Local Institution - 0297
Cordoba , X5004, Argentina
Local Institution - 0272
Córdoba , 5016, Argentina
Local Institution - 0182
Garran Australian Capital Territory, 2605, Australia
Local Institution - 0301
Blacktown New South Wales, 2148, Australia
Local Institution - 0300
Gosford New South Wales, 2250, Australia
Local Institution - 0183
Tamworth New South Wales, 2340, Australia
Local Institution - 0045
Brisbane Queensland, 4102, Australia
Local Institution - 0046
Elizabeth Vale South Australia, 5112, Australia
Local Institution - 0043
Clayton Victoria, 3168, Australia
Local Institution - 0042
Fitzroy Victoria, 3065, Australia
Local Institution - 0180
Perth Western Australia, 6150, Australia
Local Institution - 0040
Murdoch , 6150, Australia
Local Institution - 0241
Graz , 8036, Austria
Local Institution - 0240
Vienna , 1090, Austria
Local Institution - 0239
Wels , 4600, Austria
Local Institution - 0121
Roeselare West-Vlaanderen, 8800, Belgium
Local Institution - 0030
Edegem , 2650, Belgium
Local Institution - 0031
Gent , 9000, Belgium
Local Institution - 0034
Gilly , 6060, Belgium
Local Institution - 0117
Hasselt , 3500, Belgium
Local Institution - 0033
Sint Niklaas , 9100, Belgium
Local Institution - 0125
Salvador Bahia, 40170, Brazil
Local Institution - 0124
Ijui RIO Grande DO SUL, 98700, Brazil
Local Institution - 0123
Porto Alegre Rio Grande Do Sul, 90610, Brazil
Local Institution - 0127
Barretos Sao Paulo, 14784, Brazil
Local Institution - 0129
Rio De Janeiro , 20231, Brazil
Local Institution - 0144
Sao Paulo , 01321, Brazil
Local Institution - 0126
Sao Paulo , 01509, Brazil
Local Institution - 0128
Sao Paulo , 05403, Brazil
Local Institution - 0103
Edmonton Alberta, T6G 1, Canada
Local Institution - 0290
St. John's Newfoundland and Labrador, A1B 3, Canada
Local Institution - 0104
London Ontario, N6A 5, Canada
Local Institution - 0122
Montreal Quebec, H3T 1, Canada
Local Institution - 0106
Quebec City Quebec, G1J 1, Canada
Local Institution - 0107
Rimouski Quebec, G5L 5, Canada
Local Institution - 0291
Sherbrooke Quebec, J1H 5, Canada
Local Institution - 0292
Trois-Rivieres Quebec, G8Z 3, Canada
Local Institution - 0302
Quebec , G1V 4, Canada
Local Institution - 0173
Santiago Metropolitana, 75009, Chile
Local Institution - 0131
Santiago Metropolitana, 84203, Chile
Local Institution - 0174
Vina Del Mar Valparaiso, 254 0, Chile
Local Institution - 0380
Hefei Anhui, 23000, China
Local Institution - 0313
Beijing Beijing, 10000, China
Local Institution - 0315
Beijing Beijing, 10002, China
Local Institution - 0316
Beijing Beijing, 10002, China
Local Institution - 0314
Beijing Beijing, 10003, China
Local Institution - 0365
Chongqing Chongqing, 40003, China
Local Institution - 0364
Chongqing Chongqing, 40003, China
Local Institution - 0378
Chongqing Chongqing, 40004, China
Local Institution - 0322
Guangzhou Guangdong, 51006, China
Local Institution - 0372
Guangzhou Guangdong, 51009, China
Local Institution - 0319
Guanzhou Guangdong, 51008, China
Local Institution - 0325
Haerbin Heilongjiang, 15008, China
Local Institution - 0324
Zhengzhou Henan, 0, China
Local Institution - 0379
Zhengzhou Henan, 45005, China
Local Institution - 0375
Wuhan Hubei, 43002, China
Local Institution - 0362
Changsha Hunan, 41001, China
Local Institution - 0347
Nanchang Jiangxi, 0, China
Local Institution - 0329
Changchun Jilin, 13001, China
Local Institution - 0361
Changchun Jilin, 13002, China
Local Institution - 0359
Shenyang Liaoning, 11000, China
Local Institution - 0371
Xi'an Shaanxi, 71006, China
Local Institution - 0333
Xi'an Shan3xi, 71003, China
Local Institution - 0360
Qingdao Shandong, 26606, China
Local Institution - 0334
Shanghai Shanghai, 20003, China
Local Institution - 0376
Chengdu Sichuan, 61004, China
Local Institution - 0373
Tianjin Tianjin, 30006, China
Local Institution - 0340
Urumqi Xinjiang, 83001, China
Local Institution - 0343
Hangzhou Zhejiang, 31000, China
Local Institution - 0370
Hangzhou Zhejiang, 31000, China
Local Institution - 0342
Hangzhou Zhejiang, 31002, China
Local Institution - 0328
Changsha , 0, China
Local Institution - 0323
Haikou , 57031, China
Local Institution - 0341
Hangzhou , 31001, China
Local Institution - 0345
Kunming , 0, China
Local Institution - 0336
Shanghai , 20003, China
Local Institution - 0337
Shanghai , 20003, China
Local Institution - 0374
Shantou , 0, China
Local Institution - 0273
Pereira Risaralda, 0, Colombia
Local Institution - 0237
Bogota , 0, Colombia
Local Institution - 0238
Bogota , 0, Colombia
Local Institution - 0282
Medellin , 05003, Colombia
Local Institution - 0112
Hradec Kralove , 500 0, Czechia
Local Institution - 0113
Olomouc , 779 0, Czechia
Local Institution - 0111
Praha 4 , 140 5, Czechia
Local Institution - 0232
Pribram , 261 0, Czechia
Local Institution - 0270
Oulu , 90029, Finland
Local Institution - 0271
Turku , 20520, Finland
Local Institution - 0222
Bron Rhône, 69677, France
Local Institution - 0216
ANGERS Cedex 2 , 49055, France
Local Institution - 0229
Besançon Cedex , 0, France
Local Institution - 0283
Caen , 14076, France
Local Institution - 0218
Creteil , 94010, France
Local Institution - 0228
Limoges , 87042, France
Local Institution - 0215
Marseille Cedex 20 , 13915, France
Local Institution - 0230
Paris , 75018, France
Local Institution - 0227
Pessac , 33604, France
Local Institution - 0223
Rennes , 35033, France
Local Institution - 0225
Rouen Cedex , 76038, France
Local Institution - 0221
Saint Priest En Jarez , 42271, France
Local Institution - 0217
Saint-herblain Cedex , 44805, France
Local Institution - 0224
Strasbourg , 67000, France
Local Institution - 0226
Toulon , 83056, France
Local Institution - 0231
Magdeburg Sachsen-Anhalt, 39120, Germany
Local Institution - 0213
Bad Berka , 99437, Germany
Local Institution - 0208
Berlin , 13125, Germany
Local Institution - 0205
Essen , 45147, Germany
Local Institution - 0210
Frankfurt , 60590, Germany
Local Institution - 0211
Gera , 07548, Germany
Local Institution - 0203
Grosshansdorf , 22927, Germany
Local Institution - 0209
Halle , 06120, Germany
Local Institution - 0202
Heidelberg , 69126, Germany
Local Institution - 0214
Hemer , 58675, Germany
Local Institution - 0206
Immenstadt , 87509, Germany
Local Institution - 0204
Muenchen , 81925, Germany
Local Institution - 0201
Stuttgart , 70376, Germany
Local Institution - 0212
Wiesbaden , 65199, Germany
Local Institution - 0094
Athens Attikí, 115 2, Greece
Local Institution - 0095
Heraklion , 711 1, Greece
Local Institution - 0190
Neo Faliro , 18547, Greece
Local Institution - 0101
Thessaloniki , 54007, Greece
Local Institution - 0025
Budapest , 1083, Hungary
Local Institution - 0024
Budapest , 1121, Hungary
Local Institution - 0026
Matrahaza , 3233, Hungary
Local Institution - 0054
Dublin 8 Dublin, , Ireland
Local Institution - 0053
Dublin , 9, Ireland
Local Institution - 0055
Galway , 0, Ireland
Local Institution - 0100
Limerick , 0, Ireland
Local Institution - 0187
Jerusalem , 91120, Israel
Local Institution - 0186
Kfar-saba , 44281, Israel
Local Institution - 0185
Petach Tikva , 49100, Israel
Local Institution - 0184
Tel-hashomer , 52621, Israel
Local Institution - 0188
Zerifin , 70300, Israel
Istituto Europeo di Oncologia IRCCS
Milan Lombardia, 20141, Italy
Azienda Ospedaliera Moscati
Avellino , 83024, Italy
ASST Papa Giovanni XXIII
Bergamo , 24127, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna , 40138, Italy
Local Institution - 0084
Livorno , 57124, Italy
Policlinico G. Martino
Messina , 98125, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan , 20133, Italy
Istituto Nazionale Tumori Fondazione Pascale
Napoli , 80131, Italy
S.C. Di Oncologia Medica Azienda Ospedaliera Di Perugia
Perugia , 06132, Italy
Ospedale Santa Maria delle Croci
Ravenna , 48121, Italy
Ifo-Istituto Regina Elena
Roma , 00144, Italy
Local Institution - 0089
Roma , 00161, Italy
Ospedale S.Maria
Terni , 05100, Italy
Local Institution - 0153
Nagoya-shi Aichi, 46000, Japan
Local Institution - 0152
Nagoya Aichi, 46486, Japan
Local Institution - 0260
Chiba-shi Chiba, 26086, Japan
Local Institution - 0148
Kashiwa-shi Chiba, 27785, Japan
Local Institution - 0159
Matsuyama Ehime, 791-0, Japan
Local Institution - 0160
Fukuoka-shi Fukuoka, 81200, Japan
Local Institution - 0259
Kurume-shi Fukuoka, 83000, Japan
Local Institution - 0255
Ota-shi Gunma, 37308, Japan
Local Institution - 0258
Hiroshima-shi Hiroshima, 73085, Japan
Local Institution - 0163
Sapporo-shi Hokkaido, 00308, Japan
Local Institution - 0253
Sapporo-shi Hokkaido, 06086, Japan
Local Institution - 0252
Akashi-shi Hyogo, 67385, Japan
Local Institution - 0156
Kobe-shi Hyogo, 65000, Japan
Local Institution - 0146
Kanazawa-shi Ishikawa, 92086, Japan
Local Institution - 0161
Yokohama-shi Kanagawa, 22108, Japan
Local Institution - 0150
Yokohama-Shi Kanagawa, 23600, Japan
Local Institution - 0275
Natori-shi Miyagi, 98112, Japan
Local Institution - 0254
Sendai-shi Miyagi, 98008, Japan
Local Institution - 0145
Sendai-shi Miyagi, 98085, Japan
Local Institution - 0164
Niigata-shi Niigata, 95185, Japan
Local Institution - 0158
Kurashiki-shi Okayama, 71000, Japan
Local Institution - 0155
Hirakata-shi Osaka, 57311, Japan
Local Institution - 0154
Osaka-shi Osaka, 53400, Japan
Local Institution - 0251
Osakasayama-shi Osaka, 58900, Japan
Local Institution - 0257
Takatsuki-shi Osaka, 56986, Japan
Local Institution - 0353
Hidaka-shi Saitama, 35012, Japan
Local Institution - 0256
Kitaadachi-gun Saitama, 36208, Japan
Local Institution - 0151
Sunto-gun Shizuoka, 41187, Japan
Local Institution - 0147
Chuo-ku Tokyo, 10400, Japan
Local Institution - 0149
Koto-ku Tokyo, 13585, Japan
Local Institution - 0278
Shinjuku-ku Tokyo, 16000, Japan
Local Institution - 0157
Wakayama-shi Wakayama, 641-8, Japan
Local Institution - 0354
Ube-shi Yamaguchi, 75502, Japan
Local Institution - 0165
Okayama , 700-8, Japan
Local Institution - 0162
Tokyo , 113-8, Japan
Local Institution - 0136
Seongnam-si Kyǒnggi-do, 436-7, Korea, Republic of
Local Institution - 0249
Cheongju-si , 28644, Korea, Republic of
Local Institution - 0133
Gangnam-gu , 06351, Korea, Republic of
Local Institution - 0132
Seoul , 05505, Korea, Republic of
Local Institution - 0135
Seoul , 06591, Korea, Republic of
Local Institution - 0287
Beirut , 00961, Lebanon
Local Institution - 0286
Beirut , 16683, Lebanon
Local Institution - 0196
Df Distrito Federal, 06720, Mexico
Local Institution - 0193
Mexico Distrito Federal, 14080, Mexico
Local Institution - 0198
Cuautitlan Estado DE Mexico, 54769, Mexico
Local Institution - 0197
Guadalajara Jalisco, 44270, Mexico
Local Institution - 0191
Zapopan Jalisco, 44280, Mexico
Local Institution - 0267
Morelia Michoacan, 58000, Mexico
Local Institution - 0277
Monterrey Nuevo Leon, 64060, Mexico
Local Institution - 0303
Merida Yucatán, 97070, Mexico
Local Institution - 0192
Chihuahua , 31217, Mexico
Local Institution - 0195
San Luis Potosi , 78200, Mexico
Local Institution - 0236
San Luis Potosi , 78213, Mexico
Local Institution - 0194
Toluca , 50180, Mexico
Local Institution - 0036
Amsterdam , 1066 , Netherlands
Local Institution - 0189
Amsterdam , 1081 , Netherlands
Local Institution - 0169
Breda , 4818 , Netherlands
Local Institution - 0037
Rotterdam , 3014 , Netherlands
Local Institution - 0039
Veldhoven , 5504 , Netherlands
Local Institution - 0262
Lima , 0, Peru
Local Institution - 0263
Lima , 0, Peru
Local Institution - 0350
Lima , 27, Peru
Local Institution - 0261
Lima , 34, Peru
Local Institution - 0351
Lima , Lima , Peru
Local Institution - 0060
Bydgoszcz , 85-79, Poland
Local Institution - 0058
Gdansk , 80-19, Poland
Local Institution - 0063
Gdynia , 81-51, Poland
Local Institution - 0072
Gliwice , 44-10, Poland
Local Institution - 0057
Lodz , 93-51, Poland
Local Institution - 0059
Warszawa , 02-78, Poland
Local Institution - 0070
Wroclaw , 52-22, Poland
Local Institution - 0167
Craiova , 20054, Romania
Local Institution - 0250
Floresti , 40728, Romania
Local Institution - 0166
Romania , 40001, Romania
Local Institution - 0284
Sector 2 , 02232, Romania
Local Institution - 0137
Chelyabinsk , 45404, Russian Federation
Local Institution - 0142
Kazan , 42002, Russian Federation
Local Institution - 0022
Moscow , 11547, Russian Federation
Local Institution - 0049
Saint-Petersburg , 19775, Russian Federation
Local Institution - 0028
St. Petersburg , 19429, Russian Federation
Local Institution - 0027
St. Petersburg , 19825, Russian Federation
Local Institution - 0143
Ufa , 45005, Russian Federation
Local Institution - 0264
Pretoria Gauteng, 0002, South Africa
Local Institution - 0234
Sandton Gauteng, 2196, South Africa
Local Institution - 0233
Saxonwold, Johannesburg Gauteng, 2196, South Africa
Local Institution - 0305
Vereeniging , 1936, South Africa
Local Institution - 0064
Majadahonda Madrid, 28222, Spain
Local Institution - 0066
Barcelona , 08035, Spain
Local Institution - 0067
Barcelona , 08916, Spain
Local Institution - 0065
Madrid , 28041, Spain
Local Institution - 0069
Sevilla , 41013, Spain
Local Institution - 0068
Valencia , 46014, Spain
Local Institution - 0243
Basel , 4031, Switzerland
Local Institution - 0246
Chur , 7000, Switzerland
Local Institution - 0244
Lausanne , 1011, Switzerland
Local Institution - 0245
Winterthur , 8401, Switzerland
Local Institution - 0139
Taichung , 407, Taiwan
Local Institution - 0138
Taipei , 100, Taiwan
Local Institution - 0140
Taipei , 112, Taiwan
Local Institution - 0310
Taipei , 235, Taiwan
Local Institution - 0141
Taoyuan city , 333, Taiwan
Local Institution - 0266
Middlesborough Cleveland, TS4 3, United Kingdom
Local Institution - 0098
London Greater London, SW3 6, United Kingdom
Local Institution - 0099
Southampton Hampshire, SO16 , United Kingdom
Local Institution - 0118
Leicester Leicestershire, LE1 5, United Kingdom
Local Institution - 0265
Birmingham , B4 6D, United Kingdom
Local Institution - 0051
Cambridgeshire , CB2 2, United Kingdom
Local Institution - 0109
Edinburgh , EH4 2, United Kingdom
Local Institution - 0097
London , N18 1, United Kingdom
Local Institution - 0050
London , SE1 9, United Kingdom
Local Institution - 0119
Surrey , SM2 5, United Kingdom
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How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

2748

Study ID:

NCT02477826

Recruitment Status:

Active, not recruiting

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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