Lung Cancer Clinical Trial
Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
LN-145 is a ready-to-infuse TIL therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI and further optimized by Iovance for the treatment of patients with metastatic NSCLC. The cell transfer therapy used in this study involves patients receiving a non-myeloablative (NMA) lymphodepleting preparative regimen, followed by infusion of autologous TIL, then finally followed by the administration of IL-2.
Patients who are over 70 years of age may be allowed to enroll after consultation with the Medical Monitor.
Have historically or pathologically confirmed diagnosis of metastatic Stage IV NSCLC without EGFR, ALK, or ROS genomic alterations.
For patients who have actionable mutations (other than EGFR, ALK, or ROS genomic alterations), 1 additional line of therapy with the appropriate health authority approved targeted therapy is required.
Patients must have documented radiographic disease progression on or after the first-line therapy, including concurrent or sequential ICI and platinum-based chemotherapy ± bevacizumab. No more than 1 prior line is allowed if ICI and platinum-based chemotherapy were administered concurrently and no more than 2 prior lines are allowed for sequential administration of platinum-based chemotherapy and ICI as 2 separate lines.
LN-145 manufacture is allowed for patients who have residual resectable disease after completion of the platinum-based chemotherapy component of the front-line ICI and platinum-based chemotherapy combination and meet all eligibility criteria except documented disease progression. These patients must intend to receive TIL therapy after disease progression
Prior systemic therapy in the adjuvant or neoadjuvant setting, or as part of definitive chemoradiotherapy, will count as a line of therapy if the patient had disease progression during or within 12 months after the completion of such therapy.
At least 1 resectable lesion for TIL production and at least one remaining measurable lesion, as defined by RECIST v1.1
Have adequate organ function
LVEF > 45%, NYHA Class 1
Have adequate pulmonary function
ECOG performance status of 0 or 1
Patients of childbearing potential or those with partners of childbearing potential must be willing to practice an approved method of highly effective birth control during treatment and up to 12 months after all protocol-related therapy
Patients who have EGFR, ALK or ROS driver mutations
Patients who have symptomatic, untreated brain metastases.
Patients who have had allogeneic organ transplant or prior cell therapy within the past 20 years
Patients who have any form of primary immunodeficiency
Patients who are on systemic steroid therapy ≥ 10 mg/day of prednisone or equivalent.
Patients who have received a live or attenuated vaccination within 28 days prior to the start of treatment
Patients who have had another primary malignancy within the previous 3 years
Participation in another interventional clinical study within 21 days
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There are 41 Locations for this study
Duarte California, 91010, United States
La Jolla California, 92037, United States
Newark Delaware, 19713, United States
Gainesville Florida, 32610, United States
Miami Florida, 33136, United States
Orlando Florida, 32804, United States
Tampa Florida, 33612, United States
Augusta Georgia, 30912, United States
Chicago Illinois, 60612, United States
Chicago Illinois, 60612, United States
Park Ridge Illinois, 60068, United States
Louisville Kentucky, 40202, United States
Baltimore Maryland, 21201, United States
Boston Massachusetts, 02215, United States
Detroit Michigan, 48201, United States
Detroit Michigan, 48202, United States
Omaha Nebraska, 68198, United States
Camden New Jersey, 08103, United States
Buffalo New York, 14263, United States
New York New York, 10029, United States
New York New York, 10065, United States
Rochester New York, 14642, United States
Chapel Hill North Carolina, 27514, United States
Charlotte North Carolina, 28204, United States
Winston-Salem North Carolina, 27103, United States
Winston-Salem North Carolina, 27157, United States
Cincinnati Ohio, 45219, United States
Columbus Ohio, 43210, United States
Oklahoma City Oklahoma, 73104, United States
Portland Oregon, 97239, United States
Natrona Heights Pennsylvania, 15065, United States
Philadelphia Pennsylvania, 19111, United States
Sioux Falls South Dakota, 57105, United States
Knoxville Tennessee, 37920, United States
Memphis Tennessee, 38120, United States
Dallas Texas, 75246, United States
Richmond Virginia, 23298, United States
Seattle Washington, 98109, United States
Toronto Ontario, M5G 2, Canada
Montréal , QC H2, Canada
Dresden , 01307, Germany
Amsterdam , 1066, Netherlands
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