Changes in Brain Structure Related to Systemic Chemotherapy Treatment: A Prospective Study in Individuals Diagnosed With Non-small Cell Lung Cancer Utilizing High-resolution Structural Magnetic Resonance Imaging

Inclusion Criteria:

Patients between the ages of 18 and 80 years old
As per self report and/or medical record female patients are either postmenopausal or not able to become pregnant
Patients with biopsy proven or suspected non-small cell lung cancer planned to undergo induction chemotherapy and surgery, OR with biopsy proven or suspected non-small cell lung cancer planned to undergo immediate surgical resection
No clinical/neurological symptoms suggestive of brain metastases by attending's judgment as documented in the medical record and/or correspondence with the research team
In the judgement of the consenting professional, patient is able to understand English, through verbal and written communication
Patient is able to undergo MRI scanning (verified with pre-MRI Safety Screening form (Appendix A) used in MSKCC MRI Centers) completed at screening and again prior to having the MRI.

Exclusion Criteria:

Patients with history of significant neurological diagnoses including stroke, tumor, dementia, epilepsy, or multiple sclerosis as indicated by medical records and/or self report
History of head injury with evidence of brain injury or loss of consciousness for > 60 minutes as per EMR or self-report
No prior treatment with chemotherapy
Participant has dentures, body jewelry or wig that they are unable to remove as per self-report
Patient reports that he/she cannot undergo MRI scanning without significant distress or discomfort
Significant psychiatric or cognitive disturbance sufficient, in the investigator's judgment, to preclude providing informed consent or participating in the study (i.e., schizophrenia).