Docetaxel and Bortezomib in Treating Patients With Progressive or Recurrent Non-Small Cell Lung Cancer

Criteria:

No other prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer for which the patient is currently in complete remission, or any other cancer for which the patient has been disease-free for 5 years.
Histologically or cytologically confirmed non-small cell lung cancer (NSCLC).
Progressive or recurrent NSCLC after treatment with 1 prior platinum-based chemotherapy regimen for metastatic disease. Prior neoadjuvant/adjuvant chemotherapy and/or concurrent chemoradiation for early-stage disease allowed.
At least 4 weeks since prior chemotherapy (6 weeks for mitomycin C or nitrosoureas) and recovered.
No prior docetaxel or bortezomib
Prior epidermal growth factor receptor inhibitor therapy allowed.
Prior paclitaxel allowed
At least 4 weeks since prior major surgery and recovered.
At least 2 weeks since prior and no concurrent enzyme-inducing anticonvulsants.
No concurrent hormonal therapy, biologic therapy, or radiotherapy to measurable lesions. Concurrent palliative radiotherapy to small-field nonindicator lesions (e.g., painful bony metastases) allowed.
Measurable disease* with >= 1 unidimensionally objectively measurable lesion, including any of the following:
Lung mass (measurable on chest x-ray, tomograms, or CT scan)
Enlarged lymph nodes
Liver metastasis (measurable as a discrete focal lesion on radionuclide or CT scan, or ultrasound)
Metastatic abdominal mass (measurable on CT scan with >= 1 perpendicular diameter ≥ the distance between cuts)
Measurable disease must be outside the previous radiation field or a new lesion must be present.
Life expectancy >= 12 weeks
Progressive disease within a previously radiated field allowed.
[Note: *Measurable disease DOES NOT include bone metastases or non-focal liver metastases].
No symptomatic or untreated brain metastasis requiring steroids. Asymptomatic, previously treated (surgical resection or radiotherapy) brain metastasis allowed provided they are neurologically stable and >= 4 weeks since prior steroids.
Creatinine clearance >= 50 mL/min
Creatinine =< 1.6 mg/dL
Bilirubin normal
AST =< 2 times upper limit of normal
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
No peripheral neuropathy >= grade 2
Absolute granulocyte count >= 1,500/mm³
Platelet count >= 100,000/mm³
Cutaneous nodule
ECOG performance status 0-1
At least 4 weeks since prior radiotherapy and recovered.