Lung Cancer Clinical Trial
EBUS TBNA After PET/CT in Diagnosing Patients With Stage I-IIA Non-small Cell Lung Cancer Evaluated for Stereotactic Body Radiation Therapy
Summary
This clinical trial studies how well endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) after positron emission tomography/computed tomography (PET/CT) scan works in diagnosing patients with stage I-IIA non-small cell lung cancer evaluated for stereotactic body radiation therapy (SBRT). Performing EBUS-TBNA after PET/CT scan may help doctors learn more about the accuracy and ways to find early stage lung cancer.
Full Description
PRIMARY OBJECTIVES:
I. To assess the use of EBUS-TBNA after a PET/CT as a means of improving the accuracy of lymph node staging in patients considered for SBRT.
SECONDARY OBJECTIVES:
I. To assess the usefulness of PET/CT as a diagnostic test in identifying N1 versus N0 staging.
II. To compare survival and recurrence rates in patients with discordant PET/CT and EBUS-TBNA.
III. To describe EBUS-TBNA and SBRT related complications.
OUTLINE:
Patients undergo EBUS-TBNA before SBRT.
After completion of study, patients are followed up at 6 weeks, then every 3 months for the first 2 years then twice a year for the following 3 years, and annually thereafter.
Eligibility Criteria
Inclusion Criteria:
Patient must be > 18 years old
Patient must have proven or suspected non small cell lung cancer (NSCLC) and be clinical Stage I or IIa, according to the 7th edition staging system of the American Joint Commission on Cancer for lung cancer (T1 or T2a, N0 or N1, M0)
Patient must have a PET/CT obtained within 40 days of having the EBUS-TBNA
Patient is being considered for SBRT
Patient or the patient's legally authorized representative must provide written informed consent prior to registration and any study-related procedures
If the patient is a survivor of a prior invasive cancer, all of the following criteria must apply: a) Patient has undergone potentially curative therapy for all prior malignancies b) No evidence of active / recurrent disease within 5 years
Exclusion Criteria:
Patient has received prior chemotherapy or radiotherapy for this cancer
Patients already scheduled to receive conventional radiotherapy, chemotherapy, biological therapy, vaccine therapy, or surgery as treatment (except at disease progression)
Patients malignancy is consistent with well differentiated neuroendocrine (carcinoid) histology
Patients who are planning to undergo treatment in a different institution
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There is 1 Location for this study
Houston Texas, 77030, United States
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