Improving Pulmonary Function Following Radiation Therapy

Inclusion Criteria:

Histologic diagnosis of non-small cell lung cancer or lung metastasis from a solid tumor. One biopsy site is adequate for multiple sites of thoracic disease.
Treatment includes localized radiation therapy with or without chemotherapy
Karnofsky ≥ 60%
Not pregnant per radiation oncology standard procedures
Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

Prior (within last 6 months) or future planned therapeutic surgery for the treatment of the existing lung cancer
Prior thoracic radiotherapy
Severe COPD defined as disease requiring an inpatient stay for respiratory deterioration within the past 3 months
Oxygen dependence of > 2 L/min continuously throughout the day at baseline
Known underlying collagen vascular disease or intrinsic lung disease that could complicate expected sequelae of radiation (idiopathic pulmonary fibrosis, Wegener's granulomatosis)
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.