Lung Cancer Clinical Trial
Liquid Biopsy for Early Non-small Lung Cancer Detection
Summary
This clinical trial will assess the performance of a liquid biopsy assay to identify cancer in indeterminant pulmonary nodules identified by CT screening of high-risk individuals and evaluate the capability of the liquid biopsy assay to monitor response to surgical resection.
Full Description
This clinical study examines the feasibility of a liquid biopsy methylation assay to detect non-small lung cancer. First, the investigators will apply their liquid biopsy assay to screen for lung cancer in indeterminate pulmonary nodules suspicious for cancer. Second, the investigators will assess the utility of liquid biopsy to assess tumor dynamics after surgical resection with curative intent. Third, the investigators will assess the presence or absence of this methylation assay in healthy normal persons without a history of lung cancer.
Eligibility Criteria
Indeterminate pulmonary nodule study cohort
Inclusion criteria: Patients undergoing a biopsy of an indeterminate lung nodule by surgical excision, bronchoscopic biopsy or Interventional Radiology directed biopsy
Exclusion criteria: No known concurrent cancer
Known lung cancer for surgical resection study cohort
Inclusion criteria: Patients with known non-small cell lung cancer who will have surgical resection for treatment
Exclusion criteria: N/A
Healthy volunteer cohort
Inclusion criteria: Healthy persons
Exclusion criteria: No known current cancer or history of cancer within 5 years
Benign lung disease cohort
Inclusion criteria: Patients with the following categories of benign lung disease: COPD/emphysema, Granulomatous infection, Interstitial lung disease including pulmonary fibrosis and interstitial lung disease.
Exclusion criteria: N/A
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There is 1 Location for this study
Tucson Arizona, 85724, United States
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