Lung Cancer Clinical Trial
Lung Cancer Biomarkers and Screening
RATIONALE: Screening tests that use biomarkers may help doctors find tumor cells early and plan effective treatment for lung cancer.
PURPOSE: This clinical trial is studying biomarkers in screening participants for lung cancer.
Identify and validate biomarkers for the early detection of lung cancer in individuals at low- or high-risk for smoking-related cancers.
Identify preneoplastic cellular changes and lesions in these patients.
OUTLINE: Participants are stratified according to lung cancer risk status (with or without increased risk).
Group 1 (screening cohort): Participants complete a questionnaire and undergo pulmonary function testing, multidetector chest CT scan, sputum induction, and phlebotomy.
Group 2 (rule-out lung cancer): Participants complete the same questionnaire and undergo the same tests and scans as in group 1. Some participants may undergo fiberoptic bronchoscopy based upon CT scan results with transbronchial or endobronchial biopsies. Some participants may undergo lung resection. Tissue samples are collected from surgery or biopsy.
PROJECTED ACCRUAL: A total of participants will be accrued for this study.
At high- or low-risk for lung cancer
Smoking history ≥ 20 pack years*
With or without workplace exposure to asbestos
NOTE: * Participants with < 20 pack years of smoking are eligible if 50 years of age or older
Rule-Out Lung cancer group
Referred for evaluation of suspicious nodules with 1 of the following diagnoses:
Nonmalignant nodules (control group)
No prior malignancy except nonmelanoma skin cancer
PRIOR CONCURRENT THERAPY:
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