Novel Lung Functional Imaging for Personalized Radiotherapy

Inclusion Criteria:

Primary lung cancer or metastatic disease to the lungs to be treated with either conventionally-fractionated radiotherapy (CFRT) or hypo-fractionated stereotactic ablative radiotherapy (SABR).
Age restriction and/or gender/ethnic restrictions: Patients must be ≥18 years of age. There are no gender or ethnic restrictions.
Concurrent chemotherapy is allowed, but not required.
Life expectancy with treatment should be ≥6 months in the estimation of the treating physicians.
Zubrod performance status ≤2
Adequate marrow and hepatic function defined as Hgb ≥8; platelets ≥100k; ANC≥1500; LFTs ≤2x upper limit of normal and creatinine ≤1.3 or creatinine clearance of ≥50
Patient must be able to provide study specific informed consent prior to study entry.

Exclusion Criteria:

Prior radiotherapy for thoracic cancer or other malignancy leading to any overlap of planned radiotherapy fields.
For patients undergoing definitive CFRT, patients with distant metastatic disease are not eligible.
For patients undergoing SABR, both early stage primary lung cancer patients and those with limited metastatic disease to the lungs are eligible; however, patients with oligometastatic disease should have a controlled primary and no more than one other involved organ system.
Children (<18 years of age), pregnant women, University of California employees or students, or prisoners will be excluded from this study.