Lung Cancer Clinical Trial

Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may make tumor cells more sensitive to radiation therapy.

PURPOSE: Phase II trial to study the effectiveness of paclitaxel and cisplatin plus radiation therapy followed by filgrastim in treating patients who have recurrent head and neck cancer or lung cancer.

View Full Description

Full Description

OBJECTIVES: I. Determine the response rate of patients with locally recurrent carcinoma of the head and neck or lung treated with paclitaxel and cisplatin with concurrent radiotherapy followed by filgrastim (G-CSF). II. Assess the toxicity of this regimen in these patients. III. Determine the time to progression and the sites and pattern of progression in patients treated with this regimen. IV. Determine the median, 1-year, and 2-year survival rates of patients treated with this regimen.

OUTLINE: This is a multicenter study. Patients are stratified according to disease (squamous cell carcinoma of the head and neck vs salivary gland malignancy or other non-squamous cell carcinoma of the head and neck vs lung cancer). Patients receive paclitaxel IV over 1 hour and cisplatin IV over 30-120 minutes on days 1-5. Patients undergo radiotherapy twice daily on days 1-5. Patients receive filgrastim (G-CSF) subcutaneously on days 6-13 or until blood counts recover. Treatment repeats every 2 weeks for a total of 4 courses in the absence of unacceptable toxicity or disease progression. Patients are followed every 2 months.

PROJECTED ACCRUAL: A total of 42-84 patients (14-28 per stratum) will be accrued for this study within 2-4 years.

View Eligibility Criteria

Eligibility Criteria

DISEASE CHARACTERISTICS: Diagnosis of 1 of the following: Previously irradiated, locally recurrent squamous cell carcinoma of the head and neck (SCCHN) or head and neck skin/appendages with no distant metastases New second or subsequent primary SCCHN in a previously irradiated field with no distant metastases Salivary gland malignancy or other non-squamous cell primary head and neck cancer Previously irradiated, locally recurrent carcinoma of the lung No clinical evidence of symptomatic bone or brain metastases requiring radiotherapy No leptomeningeal metastases requiring intrathecal therapy

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: Not specified Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL SGOT no greater than 3 times upper limit of normal Renal: Creatinine no greater than 1.5 mg/dL OR Creatinine clearance at least 60 mL/min Cardiovascular: No active, uncontrolled congestive heart failure or arrhythmia within the past 6 months Other: No pre-existing neuropathy grade 2 or greater interfering with daily activities No prior allergy to drugs using Cremophor EL No hypersensitivity to E. coli-derived proteins No significant concurrent medical or psychiatric disorder that would preclude study No other condition that would preclude study Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for at least 3 months after study

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: At least 4 weeks since prior chemotherapy Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics At least 3 months since prior radiotherapy Prior or concurrent cumulative radiotherapy dose to spinal cord no greater than 5,000 cGy Surgery: Not specified Other: Concurrent beta-blockers, digitalis derivatives, or calcium-channel blocking agents allowed if cardiac conditions are stable

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

29

Study ID:

NCT00021333

Recruitment Status:

Completed

Sponsor:

Fox Chase Cancer Center

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 18 Locations for this study

See Locations Near You

Hunterdon Regional Cancer Center
Flemington New Jersey, 08822, United States
Kimball Medical Center
Lakewood New Jersey, 08701, United States
South Jersey Regional Cancer Center
Millville New Jersey, 08332, United States
Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
Mount Holly New Jersey, 08060, United States
Riverview Medical Center - Booker Cancer Center
Red Bank New Jersey, 07701, United States
Community Medical Center
Toms River New Jersey, 08755, United States
St. Francis Medical Center
Trenton New Jersey, 08629, United States
Bon Secours-Holy Family Health System
Altoona Pennsylvania, 16602, United States
Delaware County Memorial Hospital
Drexel Hill Pennsylvania, 19026, United States
Pinnacle Health Hospitals
Harrisburg Pennsylvania, 17105, United States
Conemaugh Memorial Hospital
Johnstown Pennsylvania, 15905, United States
Saint Mary Regional Center
Langhorne Pennsylvania, 19047, United States
Central Montgomery Medical Center
Lansdale Pennsylvania, 19446, United States
Paoli Memorial Hospital
Paoli Pennsylvania, 19301, United States
Fox Chase Cancer Center
Philadelphia Pennsylvania, 19111, United States
Pottstown Memorial Regional Cancer Center
Pottstown Pennsylvania, 19464, United States
Reading Hospital and Medical Center
Reading Pennsylvania, 19612, United States
Southern Chester County Medical Center
West Grove Pennsylvania, 19390, United States

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

29

Study ID:

NCT00021333

Recruitment Status:

Completed

Sponsor:


Fox Chase Cancer Center

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.

Please confirm you are a US based health care provider:

Yes, I am a health care Provider No, I am not a health care provider