Lung Cancer Clinical Trial
Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in participants with medullary thyroid cancer (MTC), RET-altered NSCLC and other RET-altered solid tumors.
The study consists of 2 parts, a dose-escalation part (Phase 1) and an expansion part (Phase 2). Both parts will enroll participants with advanced non-resectable NSCLC, advanced non-resectable thyroid cancer and other advanced solid tumors that have progressed following standard systemic therapy, have not adequately responded to standard systemic therapy, or the participants must be intolerant to or the Investigator has determined that treatment with standard therapy is not appropriate, or there must be no accepted standard therapy for their disease.
Key Inclusion Criteria:
Diagnosis during dose escalation (Phase 1) - Pathologically documented, definitively diagnosed non-resectable advanced solid tumor.
All participants treated at doses > 120 mg per day must have MTC, or a RET-altered solid tumor per local assessment of tumor tissue and/or blood.
Diagnosis during dose expansion (Phase 2) - All participants (with the exception of participants with MTC enrolled in Groups 3, 4, and 9) must have an oncogenic RET-rearrangement/fusion or mutation (excluding synonymous, frameshift, and nonsense mutations) solid tumor, as determined by local or central testing of tumor or circulating tumor nucleic acid in blood; as detailed below.
Group 1 - participants must have pathologically documented, definitively diagnosed locally advanced or metastatic NSCLC with a RET fusion previously treated with a platinum-based chemotherapy.
Group 2 - participants must have pathologically documented, definitively diagnosed locally advanced or metastatic NSCLC with a RET fusion not previously treated with a platinum-based chemotherapy, including those who have not had any systemic therapy. Prior platinum chemotherapy in the neoadjuvant and adjuvant setting is permitted if the last dose of platinum was 4 months or more before the first dose of study drug.
Group 3 - participants must have pathologically documented, definitively diagnosed advanced MTC that had progressed within 14 months prior to the Screening Visit and was previously treated with cabozantinib and/or vandetanib.
Group 4 - participants must have pathologically documented, definitively diagnosed advanced MTC that had progressed within 14 months prior to the Screening Visit and was not previously treated with cabozantinib and/or vandetanib.
Group 5 - participants must have a pathologically documented, definitively diagnosed advanced solid tumor with an oncogenic RET fusion, have previously received standard of care (SOC) appropriate for their tumor type (unless there is no accepted standard therapy for the tumor type or the Investigator has determined that treatment with standard therapy is not appropriate), and must not have been eligible for any of the other groups.
Group 6 - participants must have a pathologically documented, definitively diagnosed advanced solid tumor with an oncogenic RET fusion or mutation that was previously treated with a selective tyrosine kinase inhibitor (TKI) that inhibits RET
Group 7 - participants must have a pathologically documented, definitively diagnosed advanced solid tumor with an oncogenic RET mutation previously treated with SOC appropriate for the tumor type and not eligible for any of the other groups
Group 8 - participants must have pathologically documented, definitively diagnosed locally advanced or metastatic NSCLC with a RET fusion that was previously treated with a platinum based chemotherapy (China only).
Group 9 - participants must have pathologically documented, definitively diagnosed advanced MTC that had progressed within 14 months prior to the Screening Visit, and was not previously treated with systemic therapy (except prior cytotoxic chemotherapy is allowed) for advanced or metastatic disease (China only).
Participants must have non-resectable disease.
Dose expansion (Phase 2): Participants in all groups (except Group 7) must have measurable disease per RECIST v1.1 (or RANO, criteria if appropriate for tumor type).
Participants agrees to provide tumor tissue (archived, if available or a fresh biopsy) for RET status confirmation and is willing to consider an on-treatment tumor biopsy, if considered safe and medically feasible by the treating Investigator. For Phase 2, Group 6, participants are required to undergo a pretreatment biopsy to define baseline RET status in tumor tissue.
Participants has Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-1.
Key Exclusion Criteria:
Participant's cancer has a known primary driver alteration other than RET. For example, NSCLC with a targetable mutation in EGFR, ALK, ROS1 or BRAF; colorectal with an oncogenic KRAS, NRAS, or BRAF mutation.
Participants had any of the following within 14 days prior to the first dose of study drug:
Platelet count < 75 × 10^9/L.
Absolute neutrophil count < 1.0 × 10^9/L.
Hemoglobin < 9.0 g/dL (red blood cell transfusion and erythropoietin may be used to reach at least 9.0 g/dL, but must have been administered at least 2 weeks prior to the first dose of study drug.
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 × the upper limit of normal (ULN) if no hepatic metastases are present; > 5 × ULN if hepatic metastases are present.
Total bilirubin > 1.5 × ULN; > 3 × ULN with direct bilirubin > 1.5 × ULN in presence of Gilbert's disease.
Estimated (Cockcroft-Gault formula) or measured creatinine clearance < 40 mL/min.
Total serum phosphorus > 5.5 mg/dL
QT interval corrected using Fridericia's formula (QTcF) > 470 msec or history of prolonged QT syndrome or Torsades de pointes, or familial history of prolonged QT syndrome.
Clinically significant, uncontrolled, cardiovascular disease.
Central nervous system (CNS) metastases or a primary CNS tumor that is associated with progressive neurological symptoms.
Clinically symptomatic interstitial lung disease or interstitial pneumonitis including radiation pneumonitis
Participants in Groups 1-5 and 7 (Phase 2) previously treated with a selective RET inhibitor
Participant had a major surgical procedure within 14 days of the first dose of study drug
Participant had a history of another primary malignancy that had been diagnosed or required therapy within the a year prior to the study
Pregnant or breastfeeding female participants
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There are 64 Locations for this study
Phoenix Arizona, 85054, United States
Orange California, 92868, United States
Aurora Colorado, 80045, United States
Washington District of Columbia, 20007, United States
Jacksonville Florida, 32224, United States
Miami Florida, 33136, United States
Columbia Maryland, 21044, United States
Boston Massachusetts, 02114, United States
Ann Arbor Michigan, 48109, United States
Rochester Minnesota, 55902, United States
Saint Louis Missouri, 63110, United States
Albany New York, 12208, United States
New York New York, 10021, United States
Portland Oregon, 97239, United States
Philadelphia Pennsylvania, 19104, United States
Austin Texas, 78705, United States
Dallas Texas, 75246, United States
Houston Texas, 77030, United States
Seattle Washington, 98109, United States
Beijing , 10014, China
Chengdu , 61004, China
Chengdu , 61004, China
Chongqing , 40003, China
Fuzhou City , 35001, China
Ganzhou , 34100, China
Guangzhou City , 51066, China
Guangzhou , 51008, China
Hangzhou , 31001, China
Jinan City , 25001, China
Lanzhou , 73005, China
Shanghai City , 20012, China
Tianjing , 30006, China
Tianjin , 30006, China
Wuhan City , 43002, China
Zhejiang , 31002, China
Zhengzhou , 45000, China
Toulouse , 31059, France
Berlin , 14165, Germany
Essen , 45122, Germany
Heidelberg , 69126, Germany
Muenchen , 80336, Germany
Oldenburg , 26121, Germany
Shatin , 12345, Hong Kong
Ravenna Emilia-Romagna, 48100, Italy
Roma Lazio, 00144, Italy
Milano Lombardia, 20141, Italy
Milano Lombardia, 20162, Italy
Seoul , 03080, Korea, Republic of
Seoul , 05505, Korea, Republic of
Seoul , 06351, Korea, Republic of
Seoul , 120-7, Korea, Republic of
Amsterdam , 1066 , Netherlands
Groningen , 9713 , Netherlands
Singapore , 16961, Singapore
Hospitalet de Llobregat Barcelona, 08908, Spain
Barcelona , 08035, Spain
Barcelona , 08036, Spain
Madrid , 28034, Spain
Madrid , 28041, Spain
Taipei City , 11217, Taiwan
Taipei , 10002, Taiwan
Aberdeen , AB25 , United Kingdom
London , SE1 9, United Kingdom
London , W1G 6, United Kingdom
London , W1T 7, United Kingdom
Manchester , M20 4, United Kingdom
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