Lung Cancer Clinical Trial
Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments
Summary
This study will develop an algorithm of identifying patients with stage IV NSCLC and Melanoma who could benefit from cancer treatment they receive.
Full Description
The goal of this research study is to develop an algorithm that predicts the patient's treatment outcome.This algorithm will serve as a tool for physicians when making treatment decisions, specifically for stage IV NSCLC and malignant melanoma patients receiving anti-cancer treatments. The investigators also aim to identify the metabolic pathways that could lead to better therapeutic options. The patients will be given their treatment according to the institute's standard of care. The patients will provide two blood samples and clinical data will be collected from their medical records.
In the first part of the trial, the data obtained from the blood samples and the medical records of the patients will be used to develop the prediction algorithm, and in the second part of the trial, the algorithm will be validated by comparing the objective response rate of the patients to the theoretical response prediction of the algorithm.
Eligibility Criteria
Inclusion Criteria:
Cancer patients with stage IV NSCLC or stage IV malignant melanoma
Patient must have at least one measurable lesion and the relevant images in order to enable assessment of response
ECOG PS - 0/1-2
Normal hematologic, renal and liver function:
Absolute neutrophil count higher than 1500/mm3
Platelets count higher than 100,000/mm3
haemoglobin higher than 9 g/dL
Creatinine concentration ≤1.4 mg/dL, or creatinine clearance higher than 40 mL/min
Total bilirubin lower than 1.5 mg/dL, ALT and AST levels ≤ 3 times above the upper normal limit.
Exclusion Criteria:
Concurrent and/or other active malignancy that has required systemic treatment within 2 years of first dose of study drug
Generalized impairment or mental incompetence that would render the patient unable to understand his/her participation in the study.
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There are 17 Locations for this study
Birmingham Alabama, 35233, United States More Info
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Principal Investigator
Jacksonville Florida, 32224, United States More Info
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Miami Florida, 33136, United States More Info
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Orlando Florida, 32827, United States More Info
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Orlando Florida, 32827, United States More Info
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Rolling Meadows Illinois, 60008, United States More Info
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Cedar Rapids Iowa, 52403, United States More Info
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New Brunswick New Jersey, 08903, United States More Info
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Buffalo New York, 14263, United States More Info
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Germantown Tennessee, 38138, United States More Info
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Houston Texas, 77030, United States More Info
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Texarkana Texas, 75503, United States More Info
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Gauting , 82131, Germany
Heidelberg , 69126, Germany More Info
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Afula , , Israel More Info
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Ashkelon , , Israel More Info
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Be'er Sheva , , Israel
Be'er Ya'aqov , , Israel More Info
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Haifa , , Israel
Haifa , , Israel More Info
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Jerusalem , , Israel More Info
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Kfar Saba , , Israel More Info
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Petah tikva , , Israel More Info
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Tel Aviv , , Israel
Tel HaShomer , , Israel More Info
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Seville , , Spain More Info
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Aberdeen , , United Kingdom More Info
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Bournemouth , , United Kingdom More Info
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Bradford , BD9 6, United Kingdom More Info
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Cheltenham , , United Kingdom More Info
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Haverfordwest , SA61 , United Kingdom More Info
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Northwood , , United Kingdom More Info
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Shrewsbury , , United Kingdom More Info
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South Shields , NE34 , United Kingdom More Info
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Stevenage , , United Kingdom More Info
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Sunderland , SR4 7, United Kingdom More Info
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Swansea , , United Kingdom More Info
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Torquay , , United Kingdom More Info
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