Lung Cancer Clinical Trial

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Radiation Therapy to Relieve Symptoms in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Summary

This study will test the safety of Quad Shot radiation therapy using 2 different treatment schedules to find out what effects, if any, this treatment has on people with advanced NSCLC who are receiving systemic therapy for their cancer. The Quad Shot treatment schedule reduces the number of days needed to deliver the radiation treatments, which may be less disruptive to systemic therapy schedules.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically confirmed non-small cell lung cancer with metastatic disease detected on cross-sectional imaging with a plan for one of the following systemic therapies:

Carboplatin/paclitaxel
Carboplatin/paclitaxel/pembrolizumab
Carboplatin/pemetrexed
Carboplatin/pemetrexed/pembrolizumab
Pembrolizumab (single agent or in combination with other regimens in this list)
Cisplatin/pemetrexed
Cisplatin/pemetrexed/pembrolizumab
Pemetrexed/pembrolizumab
Pemetrexed
Nivolumab (single agent or in combination with other regimens in this list)
Ipilimumab/nivolumab
Carboplatin/etoposide
Carboplatin/etoposide/atezolizumab
Cisplatin/etoposide
Cisplatin/etoposide/atezolizumab
Durvalumab (single agent or in combination with other regimens in this list)
Atezolizumab (single agent or in combination with other regimens in this list)
Patients eligible for the systemic therapy regimens notes
Patients with Stage IV NSCLC who have symptomatic (defined by patient-reported cough, dyspnea, or hemoptysis) or near-symptomatic (determined radiographically to be threatening the airway, esophagus or vasculature) centrally located.
KPS â‰¥ 60
Age â‰¥ 18 years.
Able to provide informed consent.
Patients at reproductive potential must agree to practice an effective contraceptive method.

Exclusion Criteria:

Previous radiotherapy to the intended treatment site that precludes developing a treatment plan that respects normal tissue tolerances.
Serious medical co-morbidities precluding radiotherapy.
Pregnant or breast-feeding women.

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There are 7 Locations for this study

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Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge New Jersey, 07920, United States More Info