Study of Cryoablation for Metastatic Lung Tumors

Inclusion Criteria:

Participant must be at least 18 years old.
Participant has signed a written informed consent.
Participant presents with Stage 4 pulmonary metastatic disease with metastatic disease previously confirmed by prior biopsy; or Participant presents with Stage 4 pulmonary metastatic disease previously confirmed on imaging (for example, computerized tomography or CT) with histology proven primary cancer.
Participant has up to 6 local pulmonary metastases targetable by cryoablation.
Targeted index tumor(s) defined as intra pulmonary or pleural with a maximum size of 3.5 cm, measured in the longest cross-sectional dimension.
The target index tumor(s) is determined (by CT images) to be in a location where cryoablation is technically achievable based on the proximity of adjacent organs/ structures and is greater than 0.5 cm from any critical organ/structure (possibly achieved with additional maneuvers such as iatrogenic pneumothorax or hydrodissection).
Karnofsky Performance Scale (KPS) score greater than or equal to 60.
Platelet count greater than 50,000/millimeters (mm)^3 within 8 weeks prior to initial cryoablation procedure.
International Normalized Ratio (INR) less than 1.5 within 8 weeks prior to initial cryoablation procedure.
Participant has a life expectancy of greater than 3 months.

Exclusion Criteria:

Participant's index tumor(s) is primary lung cancer.
Participant has uncontrollable primary or metastatic disease outside of the lung.
Participant is unable to lie flat or has respiratory distress at rest.
Participant has a coagulopathy or bleeding disorder which is uncontrolled.
Absolute Neutrophil Count (ANC) <1000 within 8 weeks prior to initial cryoablation procedure.
Participant has evidence of active systemic, pulmonary, or pericardial infection.
Participant has a debilitating medical or psychiatric illness that would preclude giving informed consent or receiving optimal treatment or follow up.
Participant is currently participating in other experimental studies that could affect the primary endpoint (for example, experimental chemotherapy regimen).