Lung Cancer Clinical Trial

TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

Summary

The purpose of this study is to compare the effectiveness of TAK-788 as first-line treatment with that of platinum-based chemotherapy in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors has epidermal growth factor receptor (EGFR) exon 20 insertion mutations.

Participants will be randomly assigned to one of the two treatment groups- TAK-788 group or Platinum-based chemotherapy group.

Participants will receive TAK-788 orally and pemetrexed/cisplatin or pemetrexed/carboplatin via vein until the participants experience worsening disease (PD) as assessed by blinded independent review committee (IRC), intolerable harmful effects or another discontinuation criteria.

View Full Description

Full Description

The drug being tested in this study is called TAK-788. TAK-788 is being tested to evaluate the efficacy as a first line treatment compare with platinum-based chemotherapy in the participants with locally advanced or NSCLC whose tumors harbor EGFR exon 20 insertion mutations.

The study will enroll approximately 318 patients. Participants will be randomly assigned to one of the two treatment groups-

TAK-788 Group (Arm A)
Platinum-based Chemotherapy Group (Arm B)

The participants will be administered with TAK-788 orally in arm A and pemetrexed/cisplatin or pemetrexed/carboplatin intravenously (IV) in arm B until the participants experience progressive disease (PD) as assessed by blinded independent review committee (IRC), intolerable toxicity or another discontinuation criteria. Participants in the chemotherapy group may cross over to treatment with TAK-788 after IRC-assessed PD is documented. Randomized treatment with TAK-788 or platinum-based chemotherapy may be continued after PD, at the discretion of the investigator and with the sponsor's approval, if there is still evidence of clinical benefit.

This multi-center trial will be conducted in United States (US), Europe, and Asia. The overall time to participate in this study is until 3 years after the last participant is randomized. Participants will make multiple visits to the clinic and will be followed for survival, subsequent anticancer therapy, subsequent disease assessment outcome until disease progression on a subsequent anticancer therapy, and participant-reported health status (EuroQoL-5 Dimensions-5 Levels [EQ-5D-5L]) for 3 years after the last participant is randomized in the study and 30 days after the last dose of study drug for safety follow-up.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Male or female adult patients (aged 18 years or older)
Histologically or cytologically confirmed nonsquamous cell locally advanced not suitable for definitive therapy, recurrent, or metastatic (Stage IV) NSCLC
Documented epidermal growth factor receptor (EGFR) in-frame exon 20 insertion mutation assessed by a clinical laboratory improvements amendment (CLIA)-certified (US sites) or an accredited (outside of the US) local laboratory The EGFR exon 20 insertion mutation can be either alone or in combination with other EGFR or human epidermal growth factor receptor 2 (HER2) mutations except EGFR mutations for which there are approved anti-EGFR tyrosine kinase inhibitors [TKIs] (ie, exon 19 del, L858R, T790M, L861Q, G719X, or S768I, where X is any other amino acid)
Adequate tumor tissue available, either from primary or metastatic sites, for central laboratory confirmation of EGFR exon 20 insertion mutation
At least 1 measurable lesion per RECIST Version 1.1
Life expectancy ≥3 months
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
Adequate organ and hematologic function as defined by blood transfusions with a recommended >/ 14 day washout period.

Exclusion Criteria:

Received prior systemic treatment for locally advanced or metastatic disease, including local administration, such as intra-pleural injection of anticancer medication with the exception noted below:

Neoadjuvant or adjuvant chemotherapy/immune therapy for Stage I to III or combined modality chemotherapy/radiation for locally advanced disease is allowed if completed >6 months before the development of metastatic disease.
Received radiotherapy ≤14 days before randomization or has not recovered from radiotherapy-related toxicities
Received a moderate or strong cytochrome P450 (CYP)3A inhibitor or moderate or strong CYP3A inducer within 10 days before first dose of TAK-788
Have been diagnosed with another primary malignancy other than NSCLC
Have current spinal cord compression or leptomeningeal disease
Have uncontrolled hypertension. Participants with hypertension should be under treatment on study entry to control blood pressure
Received a live vaccine within 4 weeks before randomization per Summary of product characteristics (SmPCs) for pemetrexed, cisplatin, and carboplatin
Taking medication(s) known to be associated with the development of torsades de pointes.

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

318

Study ID:

NCT04129502

Recruitment Status:

Recruiting

Sponsor:

Takeda

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There are 164 Locations for this study

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UC San Diego Moores Cancer Center
La Jolla California, 92093, United States
City of Hope National Medical Center
Long Beach California, 90813, United States More Info
Site Contact
Contact
562-590-0345
[email protected]
Danny Nguyen
Principal Investigator
California Research Institute
Los Angeles California, 90027, United States
University of California Irvine
Orange California, 92868, United States
Stanford University
Palo Alto California, 94304, United States More Info
Site Contact
Contact
650-498-6000
[email protected]
Joel Neal
Principal Investigator
Eastern CT Hematology and Oncology Associates
Norwich Connecticut, 06360, United States More Info
Site Contact
Contact
860-886-8362
[email protected]
Dinesh Kapur
Principal Investigator
AdventHealth
Orlando Florida, 32804, United States More Info
Site Contact
Contact
407-303-2024
[email protected]
Tarek Mekhail
Principal Investigator
Northwestern University
Chicago Illinois, 60611, United States More Info
Site Contact
Contact
312-695-4549
[email protected]
Jyoti Patel
Principal Investigator
University of Maryland Greenebaum Cancer Center
Baltimore Maryland, 21201, United States
Beth Israel Deaconess Medical Center
Boston Massachusetts, 02115, United States More Info
Site Contact
Contact
617-632-6036
[email protected]
Pasi Janne
Principal Investigator
Dana Farber Cancer Institute
Boston Massachusetts, 02115, United States More Info
Site Contact
Contact
617-632-6036
[email protected]
Pasi Janne
Principal Investigator
Massachusetts General Hospital
Boston Massachusetts, 02115, United States
Icahn School of Medicine at Mount Sinai
New York New York, 10029, United States
Fox Chase Cancer Center
Philadelphia Pennsylvania, 19111, United States
Sarah Cannon Cancer Center
Nashville Tennessee, 37203, United States More Info
Site Contact
Contact
615-320-5090
mj[email protected]
Melissa Johnson
Principal Investigator
Texas Oncology-Baylor Charles A. Sammons Cancer Center - USOR
Dallas Texas, 75246, United States
University of Virginia Health System
Charlottesville Virginia, 22908, United States More Info
Site Contact
Contact
215-527-3357
[email protected]
Ryan Gentzler
Principal Investigator
St George Hospital
Kogarah New South Wales, 2137, Australia
GenesisCare North Shore
St Leonards New South Wales, 2065, Australia More Info
Site Contact
Contact
+61294631172
[email protected]
Nick Pavlakis
Principal Investigator
Princess Alexandra Hospital
Woolloongabba Queensland, 4102, Australia More Info
Site Contact
Contact
+61731762111
[email protected]
Kenneth OByrne
Principal Investigator
Flinders Medical Centre
Bedford Park South Australia, 5042, Australia More Info
Site Contact
Contact
+61883048997
[email protected]
Christos Karapetis
Principal Investigator
Royal Hobart Hospital
Hobart Tasmania, 7000, Australia
Medizinische Universitat Graz
Graz , 8036, Austria
Klinik Floridsdorf
Wien , 1210, Austria More Info
Site Contact
Contact
+431277002212
[email protected]
Maximilian Hochmair
Principal Investigator
Cliniques Universitaires Saint-Luc
Bruxelles Brussels, 1200, Belgium More Info
Site Contact
Contact
+3227642830
[email protected]
Philippe Collard
Principal Investigator
Grand Hopital de Charleroi asbl
Charleroi Hainaut, 6000, Belgium
AZ Sint-Lucas
Aalst Oost-Vlaanderen, 9300, Belgium
British Columbia Cancer Agency
Vancouver British Columbia, V5Z-4, Canada More Info
Site Contact
Contact
(604) 877-6000
[email protected]
Barbara Melosky
Principal Investigator
William Osler Health System
Brampton Ontario, L6R 3, Canada More Info
Site Contact
Contact
(905) 494-2120
[email protected]
Kirstin Perdrizet
Principal Investigator
Princess Margaret Hospital
Toronto Ontario, M5G2M, Canada More Info
Geoffrey Liu
Principal Investigator
Hopital Du Sacre Coeur de Montreal
Montreal Quebec, H4J 1, Canada More Info
Site Contact
Contact
(514) 338-2150
[email protected]
Kevin Jao
Principal Investigator
Beijing Cancer Hospital
Beijing Beijing, 10014, China More Info
Site Contact
Contact
+861088140650
[email protected]
Jian Fang
Principal Investigator
Henan Cancer Hospital
Zhengzhou Henan, 45000, China More Info
Site Contact
Contact
+8613938252350
[email protected]
Yanqiu Zhao
Principal Investigator
Jilin Cancer Hospital
Changchun Jilin, 13001, China More Info
Site Contact
Contact
+8643185871902
[email protected]
Ying Cheng
Principal Investigator
Beijing Cancer Hospital
Beijing , 10014, China More Info
Site Contact
Contact
+8613521469355
[email protected]
Jun Zhao
Principal Investigator
Beijing Chest Hospital, Capital Medical Univerity
Beijing , 10114, China More Info
Site Contact
Contact
+8613801126259
[email protected]
Baolan Li
Principal Investigator
Cancer Hospital Chinese Academy of Medical Sciences
Beijing , , China More Info
Site Contact
Contact
+8613911793771
[email protected]
Yan Wang
Principal Investigator
Sichuan Cancer Hospital & Institute
Chengdu , 61004, China More Info
Site Contact
Contact
+8613880276636
[email protected]
Juan Li
Principal Investigator
Guangdong Provincial People's Hospital
Guangzhou , 51008, China More Info
Site Contact
Contact
+8613959161908
[email protected]
Binchao Wang
Principal Investigator
The First Affiliated Hospital, College of Medicine, Zhejiang University
Hangzhou , 31000, China More Info
Site Contact
Contact
+86057187236876
[email protected]
Jianying Zhou
Principal Investigator
Harbin Medical University Tumor Hospital
Harbin , 15008, China More Info
Site Contact
Contact
+8613804552752
[email protected]
Baogang Liu
Principal Investigator
The Second Affiliated Hospital of Nanchang University
Nanchang , 33000, China
Shanghai East Hospital
Shanghai , 20012, China More Info
Site Contact
Contact
+8618964538992
[email protected]
Zhongliang Guo
Principal Investigator
Hubei Cancer Hospital
Wuhan , 43007, China
Copenhagen University Hospital
Copenhagen , 2100, Denmark
Odense Universitetshospital
Odense C , DK-50, Denmark
Centre Francois Baclesse
Caen Calvados, 14076, France More Info
Site Contact
Contact
+33231455002
[email protected]
Radj Gervais
Principal Investigator
CHU de Nantes - Hoptal Nord Laennec
Nantes Loire-Atlantique, 44000, France More Info
Site Contact
Contact
+338888888888
[email protected]
Elvire Pons
Principal Investigator
Hopital Calmette
Lille Nord, 59037, France More Info
Site Contact
Contact
+33320445612
[email protected]
Alexis Benjamin Cortot
Principal Investigator
Hopital Louis Pradel
Bron Rhone, 69500, France
Centre Leon Berard
Lyon Rhone, 69373, France More Info
Maurice Perol
Principal Investigator
Institut Gustave Roussy
Villejuif Val-de-Marne, 94805, France More Info
Site Contact
Contact
+33142114322
[email protected]
Benjamin Besse
Principal Investigator
Centre Hospitalier Intercommunal
Creteil Cedex , 94010, France
CHU de Grenoble
Grenoble , 38043, France More Info
Site Contact
Contact
+0476765453
[email protected]
Denis Moro-Sibilot
Principal Investigator
Hopital Nord AP-HM
Marseille , 13915, France More Info
Site Contact
Contact
+33491744736
[email protected]
Pascale Tomasini
Principal Investigator
CRLC Val d'Aurelle - Paul Lamarque
Montpellier , 34298, France More Info
Site Contact
Contact
+33467612581
[email protected]
Xavier Quantin
Principal Investigator
Hopital Tenon
Paris , 75020, France More Info
Site Contact
Contact
+33156016531
[email protected]
Jacques Cadranel
Principal Investigator
Hopital PONTCHAILLOU CHU de Rennes
Rennes , 35033, France
Nouvel Hopital Civil
Strasbourg , 67091, France More Info
Site Contact
Contact
+33369550644
[email protected]
Bertrand Mennecier
Principal Investigator
Hopital Larrey
Toulouse , 31059, France
Klinik Schillerhohe
Gerlingen Baden-Wurttemberg, 70839, Germany
Thoraxklinik-Heidelberg gGmbH
Heidelberg Baden-Wurttemberg, 69126, Germany More Info
Site Contact
Contact
+4962213961301
[email protected]
Michael Thomas
Principal Investigator
LMU Klinikum der Universitat Munchen
Munchen Bayern, 80336, Germany More Info
Site Contact
Contact
+4980440052590
[email protected]
Amanda Tufman
Principal Investigator
University Clinic Regensburg
Regensburg Bayern, 93053, Germany More Info
Site Contact
Contact
+499419447281
[email protected]
Christian Schulz
Principal Investigator
Universitatsklinikum Frankfurt
Frankfurt am Main Hessen, 60590, Germany More Info
Site Contact
Contact
+496963017394
[email protected]
Albera Burchardt
Principal Investigator
Pius Hospital Oldenburg
Oldenburg Niedersachsen, 26121, Germany More Info
Site Contact
Contact
+494412291611
[email protected]
Frank Griesinger
Principal Investigator
Stadtischen Krankenhaus Kiel
Kiel Schleswig-Holstein, 24116, Germany
Helios Klinikum Emil Von Behring
Berlin , 14165, Germany More Info
Site Contact
Contact
+493081021447
[email protected]
Jens Kollmeier
Principal Investigator
Malteser Krankenhaus St. Franziskus-Hospital
Flensburg , 24939, Germany
Asklepios Fachkliniken GmbH
Gauting , 82131, Germany
Sotiria Chest Hospital of Athens
Athens Attiki, 11527, Greece More Info
Site Contact
Contact
+302107700220
[email protected]
Maria Mastrogianni
Principal Investigator
Metaxa Cancer Hospital of Piraeus
Piraeus Attiki, 185 3, Greece
Bioclinic Thessaloniki (Galinos clinic)
Thessaloniki , 54007, Greece More Info
Site Contact
Contact
+302310898605
[email protected]
Ioannis Boukovinas
Principal Investigator
Princess Margaret Hospital
Kowloon Kowloon City, , Hong Kong
Pamela Youde Nethersole Eastern Hospital
Hong Kong , , Hong Kong More Info
Site Contact
Contact
+85225954183
[email protected]
Tsz Yeung Michael Kam
Principal Investigator
Queen Elizabeth Hospital (QEH)
Hong Kong , , Hong Kong More Info
Site Contact
Contact
+85229582641
[email protected]
Kam-Hung Wong
Principal Investigator
Queen Mary Hospital
Hong Kong , , Hong Kong More Info
Site Contact
Contact
+8522255499
[email protected]
James Ho
Principal Investigator
Tuen Mun Hospital
Hong Kong , , Hong Kong More Info
Site Contact
Contact
+85224685038
[email protected]
Shi Feng Nyaw
Principal Investigator
Prince of Wales Hospital
Sha Tin , , Hong Kong
Soroka University Medical Centre
Beer Sheva , 84101, Israel More Info
Site Contact
Contact
+97239378146
[email protected]
Nir Dudnik
Principal Investigator
Rambam Medical Center PPDS
Haifa , 31096, Israel
Meir Medical Center
Kfar Saba , 44281, Israel
Sheba Medical Center - PPDS
Ramat Gan , 52621, Israel More Info
Site Contact
Contact
[email protected]
Yair Bar
Principal Investigator
AORN Dei Colli- Ospedale Monaldi Napoli
Napoli Campania, 80131, Italy More Info
Site Contact
Contact
+390817064300
[email protected]
Danilo Rocco
Principal Investigator
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l - PPDS
Meldola Forli-Cesena, 47014, Italy
Istituto Nazionale Dei Tumori
Milano Lombardia, 20133, Italy More Info
Site Contact
Contact
+390223903829
[email protected]
Claudia Proto
Principal Investigator
Istituto Europeo Di Oncologia
Milano Lombardia, 20141, Italy More Info
Site Contact
Contact
+390257489449
[email protected]
Filippo De Marinis
Principal Investigator
Azienda Sanitaria Ospedaliera S Luigi Gonzaga
Orbassano Piemonte, 10043, Italy More Info
Site Contact
Contact
+390119026978
[email protected]
Silvia Novello
Principal Investigator
Centro Di Riferimento Oncologico
Aviano Pordenone, 33081, Italy More Info
Site Contact
Contact
+390434659294
[email protected]
Alessandra Bearz
Principal Investigator
Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele
Catania Sicilia, 95122, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa Toscana, 56124, Italy More Info
Site Contact
Contact
+39050993307
[email protected]
Iacopo Petrini
Principal Investigator
Azienda Ospedaliero Universitaria di Parma
Parma , 43126, Italy More Info
Site Contact
Contact
+390521702316
[email protected]
Marcello Tiseo
Principal Investigator
Ospedale Santa Maria Delle Croci
Ravenna , 48121, Italy
Fujita Health University Hospital
Toyoake-Shi Aiti, 470-1, Japan More Info
Site Contact
Contact
+81562932139
[email protected]
Yasuhiro Goto
Principal Investigator
Ehime University Hospital
Matsuyama-Shi Ehime, 791-0, Japan
Hiroshima University Hospital
Hiroshima-Shi Hirosima, 734-0, Japan
National Hospital Organization Hokkaido Cancer Center
Sapporo-Shi Hokkaido, 003-0, Japan More Info
Site Contact
Contact
+81245471111
[email protected]
Hiroshi Yokouchi
Principal Investigator
Kurume University Hospital
Kurume-Shi Hukuoka, 830-0, Japan
Kanagawa Cancer Center
Yokohama-Shi Kanagawa, 241-0, Japan More Info
Site Contact
Contact
+81455202222
[email protected]
Terufumi Kato
Principal Investigator
Saiseikai Kumamoto Hospital
Kumamoto-Shi Kumamoto, 861-4, Japan More Info
Site Contact
Contact
+81963518000
[email protected]
Kodai Kawamura
Principal Investigator
Miyagi Cancer Center
Natori-Shi Miyagi, 981-1, Japan More Info
Site Contact
Contact
+81223843151
[email protected]
Tatsuro Fukuhara
Principal Investigator
Okayama University Hospital
Okayama-Shi Okayama, 700-0, Japan More Info
Site Contact
Contact
+81862357227
[email protected]
Eiki Ichihara
Principal Investigator
Osaka Metropolitan University Hospital
Osaka-shi Osaka, 545-8, Japan
Kindai University Hospital
Osakasayama-Shi Osaka, 589-0, Japan
Saitama Cancer Center
Komoro Saitama, 362-0, Japan
National Cancer Center Hospital East
Kashiwa-Shi Tiba, 277-0, Japan
Osaka International Cancer Institute
Chuo-Ku Tokyo, 541-8, Japan More Info
Site Contact
Contact
+81669751181
[email protected]
Toru Kumagai
Principal Investigator
The Cancer Institute Hospital of Japanese Foundation For Cancer Research
Koto-Ku Tokyo, 135-0, Japan
National Hospital Organization Yamaguchi-Ube Medical Center
Ube-Shi Yamaguti, 755-0, Japan
Chungbuk National University Hospital
Cheongju-si Chungcheongbugdo, 28644, Korea, Republic of More Info
Site Contact
Contact
+82432696015
[email protected]
Ki Hyeong Lee
Principal Investigator
Pusan National University Hospital
Busan , 602-7, Korea, Republic of More Info
Site Contact
Contact
+82512407216
[email protected]
Min Ki Lee
Principal Investigator
National Cancer Center
Goyang , 41076, Korea, Republic of More Info
Site Contact
Contact
+82319201154
[email protected]
Ji-Youn Han
Principal Investigator
Chonnam National University Hwasun Hospital
Jeongnam , 519-7, Korea, Republic of More Info
Site Contact
Contact
+82613797614
[email protected]
Young-Chul Kim
Principal Investigator
Korea University Anam Hospital
Seoul , 02841, Korea, Republic of
Seoul National University Hospital
Seoul , 03080, Korea, Republic of More Info
Site Contact
Contact
+82220723559
[email protected]
Tae Min Kim
Principal Investigator
Asan Medical Center - PPDS
Seoul , 05505, Korea, Republic of More Info
Site Contact
Contact
+82230103215
[email protected]
Sang-We Kim
Principal Investigator
Samsung Medical Center PPDS
Seoul , 06351, Korea, Republic of More Info
Site Contact
Contact
+82234103438
[email protected]
Myung-Ju Ahn
Principal Investigator
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul , 06591, Korea, Republic of More Info
Site Contact
Contact
+82222587563
[email protected]
JinHyoung Kang
Principal Investigator
Severance Hospital Yonsei University Health System - PPDS
Seoul , 120-7, Korea, Republic of More Info
Site Contact
Contact
+82222288216
[email protected]
Byoung Chul Cho
Principal Investigator
VU Medisch Centrum
Amsterdam Noord-Holland, 1081 , Netherlands More Info
Site Contact
Contact
+31204444782
[email protected]
Sayed Hashemi
Principal Investigator
Centro Hospitalar do Porto Hospital de Santo Antonio
Santa Maria Da Feira Aveiro, 4520-, Portugal
Hospital Cuf Porto
Vila Nova de Gaia Porto, 4434-, Portugal More Info
Site Contact
Contact
+351220039271
[email protected]
Barbara Parente
Principal Investigator
Fundacao Champalimaud
Lisboa , 1400-, Portugal
Centro Hospitalar de Lisboa Norte E.P.E Hospital Pulido Valente
Lisboa , 1649-, Portugal More Info
Site Contact
Contact
+351217548085
[email protected]
Encarnacao Teixeira
Principal Investigator
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS
Porto , 4200-, Portugal More Info
Site Contact
Contact
+351225084000
[email protected]
Cristina Oliveira
Principal Investigator
Centro Hospitalar de Sao Joao, E.P.E.
Porto , 4200, Portugal More Info
Site Contact
Contact
+00351965744014
[email protected]
Gabriela Fernandes
Principal Investigator
GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology)
Saint Petersburg Leningradskaya Oblast, 19775, Russian Federation
Moscow City Oncology Hospital #62
Moscow , 14342, Russian Federation
LLC "EuroCityClinic"
Saint Petersburg , 19702, Russian Federation
Scientific Research Institute of Oncology n.a. N.N. Petrov
St. Petersburg , 19775, Russian Federation
National Cancer Centre
Singapore , 16960, Singapore More Info
Site Contact
Contact
(656) 222-3322
[email protected]
Tanujaa Rajasekaran
Principal Investigator
ICO lHospitalet Hospital Duran i Reynals
L'Hospitalet de Llobregat Barcelona, 08907, Spain More Info
Site Contact
Contact
+34932607744
[email protected]
Ernest Nadal
Principal Investigator
Hospital Universitario Puerta de Hierro - Majadahonda
Majadahonda Madrid, 28222, Spain
Hospital Universitario A Coruna
A Coruna , 15006, Spain
Hospital General Universitario de Alicante
Alicante , 03010, Spain More Info
Site Contact
Contact
+34965933513
[email protected]
Bartomeu Massuti Sureda
Principal Investigator
Hospital Universitario Vall d'Hebron - PPDS
Barcelona , 08035, Spain
Hospital Clinic de Barcelona
Barcelona , 08036, Spain
C.H. Regional Reina Sofia - PPDS
Cordoba , 14004, Spain More Info
Site Contact
Contact
+34957736226
[email protected]
Isidoro Carlos Barneto Aranda
Principal Investigator
Hospital General Universitario Gregorio Maranon
Madrid , 28007, Spain
Hospital Universitario Fundacion Jimenez Diaz
Madrid , 28040, Spain
Hospital Universitario 12 de Octubre
Madrid , 28041, Spain More Info
Luis Paz-Ares Rodriguez
Principal Investigator
Hospital Universitario La Paz - PPDS
Madrid , 28046, Spain More Info
Site Contact
Contact
+34917277118
[email protected]
Javier De Castro Carpeno
Principal Investigator
Hospital Regional Universitario de Malaga Hospital General
Malaga , 29010, Spain
Hospital Universitario Virgen del Rocio - PPDS
Sevilla , 41013, Spain
Hospital Universitari i Politecnic La Fe de Valencia
Valencia , 46026, Spain More Info
Site Contact
Contact
+34961245867
[email protected]
Oscar Jose Juan Vidal
Principal Investigator
Karolinska Universitetssjukhuset Solna
Stockholm Sodermanlands Lan, , Sweden
Sahlgrenska Universitetssjukhuset
Goteborg , 413 4, Sweden
Universitatsspital Basel
Basel Basel-Stadt (de), 4031, Switzerland
Kantonsspital Winterthur
Winterthur , 8401, Switzerland
Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Dalin , 622, Taiwan More Info
Chun-Liang Lai
Principal Investigator
National Taiwan University Hospital - YunLin Branch
Douliu , 640, Taiwan More Info
Site Contact
Contact
+88655323911
[email protected]
Chung-Yu Chen
Principal Investigator
Kaohsiung Medical University - Chung-Ho Memorial Hospital
Kaohsiung , 807, Taiwan
E-DA hospital
Kaohsiung , 82445, Taiwan More Info
Yu-Feng Wei
Principal Investigator
Taichung Veterans General Hospital
Taichung City , 407, Taiwan More Info
Tsung-Ying Yang
Principal Investigator
Chi Mei Medical Center, Liouying
Tainan City , 736, Taiwan More Info
Chao-Hsun Chen
Principal Investigator
National Cheng Kung University Hospital
Tainan , 704, Taiwan More Info
Wu-Chou Su
Principal Investigator
National Taiwan University Hospital
Taipei , 10002, Taiwan More Info
Chih-Hsin Yang
Principal Investigator
Taipei Veterans General Hospital
Taipei , 112, Taiwan More Info
Yuh-Min Chen
Principal Investigator
Baskent University Medical Faculty Adana Practice and Research Center
Yuregir Adana, 01120, Turkey
Istanbul University Cerrahpasa Medical Faculty Hospital
Fatih Istanbul, 34098, Turkey
T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Kadikoy Istanbul, 34772, Turkey More Info
Site Contact
Contact
+905063509061
[email protected]
Mahmut Gumus
Principal Investigator
Ege University Medical Faculty
Bornova Izmir, 35100, Turkey
Kocaeli University Hospital
Izmit Kocaeli, 41380, Turkey
SAKARYA University Medical Faculty
Karaman Sakarya, 54290, Turkey
Hacettepe University Medical Faculty
Ankara , 06100, Turkey
Trakya University Medical Faculty
Edirne , 22030, Turkey
Municipal Non-profit Enterprise "City Clinical Hospital # 4" of Dnipro City Council - PPDS
Dnipropetrovsk Dnipropetrovs'ka Oblast, 49102, Ukraine
Municipal Non-profit Enterprise SubCarpathian Clinical Oncological Centre of Ivano-Frankivsk RC
Ivano-Frankivsk Ivano-Frankivs'ka Oblast, 76018, Ukraine
Communal Non-profit Enterprise Regional Center of Oncology
Kharkiv , 61070, Ukraine
Private Enterprise Private Manufacturing Company Acinus
Kropyvnytskyi , 25006, Ukraine
Velindre Cancer Centre - PPDS
Whitchurch Cardiff, CF14 , United Kingdom
University College London Hospitals (UCLH)
London London, City Of, NW1 2, United Kingdom More Info
Site Contact
Contact
+4402076790744
[email protected]
Siow-Ming Lee
Principal Investigator
Royal Marsden Hospital - London
London London, City Of, SW3 6, United Kingdom
Royal Marsden Hospital - Surrey
Sutton Surrey, SM2 5, United Kingdom
Royal Marsden Hospital - Surrey
Sutton Surrey, SM2 5, United Kingdom More Info
Site Contact
Contact
+442078082132
[email protected]
Sanjay Popat
Principal Investigator
Clatterbridge Centre For Oncology
Bebington Wirral, CH63 , United Kingdom More Info
Site Contact
Contact
+44
[email protected]
Carles Escriu
Principal Investigator
Leicester General Hospital
Leicester , LE1 5, United Kingdom More Info
Site Contact
Contact
+441162586295
[email protected]
Samreen Ahmed
Principal Investigator
The Christie NHS Foundation Trust - PPDS
Manchester , M20 4, United Kingdom More Info
Site Contact
Contact
+4401614463745
[email protected]
Raffaele Califano
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

318

Study ID:

NCT04129502

Recruitment Status:

Recruiting

Sponsor:


Takeda

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