Lung Cancer Clinical Trial

Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy

Summary

This is a research study to evaluate the safety and effectiveness of tocilizumab in combination with atezolizumab to treat non-small cell lung cancer.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Advanced non-squamous NSCLC (Stage IV or recurrent after initial curative intent therapy) in adults age 18 or older
Prior exposure to at least 1 line of therapy
Exposure to a including checkpoint inhibitor in line of therapy immediately prior to enrollment on trial
ECOG PS 0-2

Exclusion Criteria:

Presence of a driver mutation that is susceptible to targeted therapy
No greater than CTCAE v5 grade 3 toxicity attributed to prior immunotherapy
Other active invasive malignancy requiring ongoing therapy
Evidence of progressing or untreated brain metastases
Evidence or history of leptomeningeal disease
Uncontrolled tumor related pain
History of an autoimmune disease or IPF

Study is for people with:

Lung Cancer

Phase:

Phase 1

Estimated Enrollment:

28

Study ID:

NCT04691817

Recruitment Status:

Not yet recruiting

Sponsor:

Abramson Cancer Center of the University of Pennsylvania

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There is 1 Location for this study

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Abramson Cancer Center of the University of Pennsylvania
Philadelphia Pennsylvania, 19104, United States More Info
Mel V, BA
Contact
215-220-9703
[email protected]
Melina Marmarelis, MD, MSCE
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 1

Estimated Enrollment:

28

Study ID:

NCT04691817

Recruitment Status:

Not yet recruiting

Sponsor:


Abramson Cancer Center of the University of Pennsylvania

How clear is this clinincal trial information?

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