Lung Cancer Clinical Trial

Using e-Nose Technology to Identify Early Lung Cancer

Summary

The purpose of this study is to test the ability of a new technology called breathprinting, or electronic nose (e-nose), to detect early-stage lung cancer. Additionally, researchers also want to see if the e-nose technology is more effective at diagnosing lung cancer if the tumor size is larger.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Age 21-85
Single, monolateral nodule of at least 50% solid composition visible on chest CT scan (with or without contrast) suspicious for lung cancer.
MSK radiologist report or read suggestive (i.e. at least 50% certainty) of suspected primary lung cancer (in accordance with the level of certainty criteria set forth by MSKCC Radiology)
Negative test for COVID-19 performed locally or at MSK, done as part of standard of care testing (i.e. only when required by specific institutional policy) prior to biopsy or surgical procedure
Eligible for fine-needle aspiration biopsy, robotic bronchoscopy, and/or surgical resection for diagnosis (i.e., does not have comorbidities precluding these).
Documented, signed, and dated informed consent, obtained before any procedures, for the proposed research study
Patient must agree to undergo fine-needle aspiration biopsy, robotic bronchoscopy, and/or surgical resection for diagnosis prior to e-nose collection
Patients with biopsy-proven clinical stage I lung cancer are eligible if the biopsy is done within 6 weeks of the consent date

Exclusion Criteria:

Age <21 and>85 years at first outpatient visit.
Multiple ipsilateral or bilateral nodules reported on chest CT scan and/or concurrent as suspicious for lung cancer (note: nodules deemed indeterminate, inflammatory, etc. will not exclude a patient from participating in this study) semisolid GGOs.
Lung nodule of interest is less than 50% solid in composition
Per MSK radiologist report or read, the lung nodule of interest is "less likely" or "unlikely" (i.e. less than 50% certainty) to be neoplastic (in accordance with the level of certainty criteria set forth by MSKCC Radiology)
Any previous history of lung cancer
History of any non-lung cancer(s) that is currently being treated (note: prior history of completely treated non-lung cancer from any time will be eligible)
Metastatic lung cancer disease seen on chest CT or PET scan at hilar/mediastinal nodes or contralateral lung or extrathoracic sites.
Previous medical history of a lung biopsy/surgical procedure for cancer diagnosis (note: patients who underwent a lung biopsy over three years ago that showed negative for lung cancer and patients who underwent a lung biopsy confirming stage I lung cancer within the past 6 weeks will be eligible)

Study is for people with:

Lung Cancer

Estimated Enrollment:

110

Study ID:

NCT04734145

Recruitment Status:

Recruiting

Sponsor:

Memorial Sloan Kettering Cancer Center

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There are 7 Locations for this study

See Locations Near You

Memoral Sloan Kettering Basking Ridge (Consent only)
Basking Ridge New Jersey, 07920, United States More Info
Gaetano Rocco, MD
Contact
212-639-3478
Memoral Sloan Kettering Monmouth (Consent only)
Middletown New Jersey, 07748, United States More Info
Gaetano Rocco, MD
Contact
212-639-3478
Memorial Sloan Kettering Bergen (Consent only )
Montvale New Jersey, 07645, United States More Info
Gaetano Rocco, MD
Contact
212-639-3478
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent only)
Commack New York, 11725, United States More Info
Gaetano Rocco, MD
Contact
212-639-3478
Memorial Sloan Kettering Westchester (Consent only)
Harrison New York, 10604, United States More Info
Gaetano Rocco, MD
Contact
212-639-3478
Memorial Sloan Kettering Cancer Center (All Study Activities)
New York New York, 10065, United States More Info
Gaetano Rocco, MD
Contact
212-639-3478
Memorial Sloan Kettering Nassau (Consent Only)
Uniondale New York, 11553, United States More Info
Gaetano Rocco, MD
Contact
212-639-3478

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Estimated Enrollment:

110

Study ID:

NCT04734145

Recruitment Status:

Recruiting

Sponsor:


Memorial Sloan Kettering Cancer Center

How clear is this clinincal trial information?

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