A Clinical Study of V940 Plus Pembrolizumab in People With High-Risk Melanoma (V940-001) Summary The purpose of this study is to learn if V940 which is an individualized neoantigen therapy (INT; formerly, called messenger ribonucleic acid [mRNA]-4157) with pembrolizumab (MK-3475) is safe and prevents cancer from returning in people with high-risk melanoma . Researchers want to know if V940 with pembrolizumab is better than receiving pembrolizumab alone at preventing the cancer from returning.
View Eligibility Criteria Eligibility Criteria Inclusion Criteria: The main inclusion criteria include but are not limited to the following: Has surgically resected and histologically/pathologically confirmed diagnosis of Stage IIB or IIC, III, or IV cutaneous melanoma Has not received any prior systemic therapy for their melanoma beyond surgical resection No more than 13 weeks have passed between final surgical resection that rendered the participant disease-free and the first dose of pembrolizumab Is disease free at the time of providing documented consent for the study Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on anti-retroviral therapy (ART) Exclusion Criteria: The main exclusion criteria include but are not limited to the following: Has ocular or mucosal melanoma Has cancer that has spread to other parts of the body and cannot be removed with surgery Has heart failure within the past 6 months Has received prior cancer therapy or another cancer vaccine Has another known cancer that that has spread to other parts of the body or has required treatment within the past 3 years Has severe reaction to study medications or any of their substance used to prepare a drug Have not recovered from major surgery or have ongoing surgical complications
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There are 127 Locations for this study
Highlands Oncology Group ( Site 1943) Springdale Arkansas, 72762, United States
More Info
UCLA Hematology/Oncology - Westwood (Building 100) ( Site 1918) Los Angeles California, 90095, United States
More Info
UCSF Medical Center at Mission Bay ( Site 1929) San Francisco California, 94158, United States
More Info
Yale-New Haven Hospital-Yale Cancer Center ( Site 1933) New Haven Connecticut, 06510, United States
More Info
Orlando Health Cancer Institute ( Site 1937) Orlando Florida, 32806, United States
More Info
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 1950) Marietta Georgia, 30060, United States
More Info
University of Iowa-Holden Comprehensive Cancer Center ( Site 1935) Iowa City Iowa, 52242, United States
More Info
Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center - Melanoma ( Site 1912) Baltimore Maryland, 21287, United States
More Info
Cancer and Hematology Centers of Western Michigan ( Site 1932) Grand Rapids Michigan, 49503, United States
More Info
John Theurer Cancer Center at Hackensack University Medical Center ( Site 1944) Hackensack New Jersey, 07601, United States
More Info
Atlantic Health System ( Site 1925) Morristown New Jersey, 07960, United States
More Info
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 1958) Mineola New York, 11501, United States
More Info
NYU Langone Health-Perlmutter Cancer Center ( Site 1917) New York New York, 10016, United States
More Info
Memorial Sloan Kettering Cancer Center ( Site 1914) New York New York, 10065, United States
More Info
Duke Cancer Institute ( Site 1911) Durham North Carolina, 27710, United States
More Info
Hospital of the University of Pennsylvania Perelman Center for Advanced Medicine ( Site 1905) Philadelphia Pennsylvania, 19104, United States
More Info
UPMC Hillman Cancer Center ( Site 1909) Pittsburgh Pennsylvania, 15232, United States
More Info
Sanford Cancer Center ( Site 1951) Sioux Falls South Dakota, 57104, United States
More Info
Texas Oncology - Austin ( Site 1903) Austin Texas, 78731, United States
More Info
Texas Oncology - Dallas (Sammons) ( Site 1902) Dallas Texas, 75246, United States
More Info
Inova Schar Cancer Institute ( Site 1900) Fairfax Virginia, 22031, United States
More Info
Fred Hutchinson Cancer Center ( Site 1901) Seattle Washington, 98109, United States
More Info
Hospital Aleman ( Site 2200) Buenos Aires Caba, C1118, Argentina
More Info
Centro Privado de RMI Río Cuarto S.A. II ( Site 2201) Río Cuarto Cordoba, X5800, Argentina
More Info
Sanatorio Finochietto ( Site 2205) Buenos Aires , C1187, Argentina
More Info
Clinica Adventista Belgrano-Oncology ( Site 2204) Caba , 1430, Argentina
More Info
Westmead Hospital-Department of Medical Oncology ( Site 1001) Westmead New South Wales, 2145, Australia
More Info
Melanoma Institute Australia-Clinical Trials Unit ( Site 1000) Wollstonecraft New South Wales, 2065, Australia
More Info
Princess Alexandra Hospital ( Site 1003) Brisbane Queensland, 4102, Australia
More Info
Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 1005) Melbourne Victoria, 3000, Australia
More Info
The Alfred Hospital-Medical Oncology Alfred Cancer Trials ( Site 1004) Melbourne Victoria, 3004, Australia
More Info
One Clinical Research ( Site 1002) Nedlands Western Australia, 6009, Australia
More Info
UZ Brussel-Medische oncologie ( Site 3405) Brussels Bruxelles-Capitale, Region De, 1090, Belgium
More Info
Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 3402) Genk Limburg, 3600, Belgium
More Info
UZ Gent ( Site 3403) Gent Oost-Vlaanderen, 9000, Belgium
More Info
UZ Leuven ( Site 3400) Leuven Vlaams-Brabant, 3000, Belgium
More Info
AZ Groeninge Campus Kennedylaan-Oncology ( Site 3401) Kortrijk West-Vlaanderen, 8500, Belgium
More Info
ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 2300) São Paulo Sao Paulo, 01246, Brazil
More Info
BC Cancer Vancouver-Clinical Trials Unit ( Site 1106) Vancouver British Columbia, V5Z 4, Canada
More Info
William Osler Health System ( Site 1105) Brampton Ontario, L6R 3, Canada
More Info
Sunnybrook Research Institute ( Site 1103) Toronto Ontario, M4N 3, Canada
More Info
Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 1102) Toronto Ontario, M5G 2, Canada
More Info
Centre Hospitalier de l'Université de Montréal-Unité de Recherche Clinique en Oncologie et Hématolo Montréal Quebec, H2X 0, Canada
More Info
Centre intégré de cancérologie du CHU de Québec Université L-Hemato-Oncology ( Site 1101) Quebec City Quebec, G1J 1, Canada
More Info
FALP-UIDO ( Site 2400) Santiago Region M. De Santiago, 75009, Chile
More Info
Clínica UC San Carlos de Apoquindo-Hemato-Oncology ( Site 2402) Santiago Region M. De Santiago, 76200, Chile
More Info
Bradfordhill-Clinical Area ( Site 2401) Santiago Region M. De Santiago, 84203, Chile
More Info
Herlev and Gentofte Hospital ( Site 3301) Copenhagen Hovedstaden, 2730, Denmark
More Info
Aalborg Universitetshospital, Syd ( Site 3302) Aalborg Nordjylland, 9000, Denmark
More Info
Odense Universitetshospital ( Site 3300) Odense Syddanmark, 5000, Denmark
More Info
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Dermatology Department ( Site 1211) Nice cedex 3 Alpes-Maritimes, 06200, France
More Info
Centre Georges François Leclerc ( Site 1210) Dijon Cote-d Or, 21079, France
More Info
CHU Besançon ( Site 1209) Besançon Doubs, 25030, France
More Info
CHU de Bordeaux Hop St ANDRE-Service de Dermatologie ( Site 1204) Bordeaux Gironde, 33075, France
More Info
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 1206) Rennes Ille-et-Vilaine, 35042, France
More Info
Hopital Claude Huriez - CHU de Lille ( Site 1207) Lille Nord, 59037, France
More Info
centre hospitalier lyon sud-Service de dermatologie ( Site 1202) Pierre-Bénite Rhone, 69310, France
More Info
CHU d'Amiens-Picardie - Hôpital Sud-Dermatologie ( Site 1208) Amiens Somme, 80054, France
More Info
Gustave Roussy-Dermatologie ( Site 1201) Villejuif Val-de-Marne, 94800, France
More Info
Hôpital Saint-Louis ( Site 1200) Paris , 75010, France
More Info
Universitätsmedizin Mannheim ( Site 1305) Mannheim Baden-Wurttemberg, 68167, Germany
More Info
Universitaetsklinikum Augsburg ( Site 1312) Augsburg Bayern, 86156, Germany
More Info
Klinik und Poliklinik für Dermatologie und Allergologie-Dermato-oncology ( Site 1315) München Bayern, 80337, Germany
More Info
Universitätsmedizin Rostock-Klinik und Poliklinik für Dermatologie und Venerologie ( Site 1310) Rostock Mecklenburg-Vorpommern, 18057, Germany
More Info
Universitätsmedizin Göttingen - Georg-August-Universität-Dermatology ( Site 1308) Göttingen Niedersachsen, 37075, Germany
More Info
Universitaetsklinikum Essen-Klinik für Dermatologie, Venerologie und Allergologie ( Site 1300) Essen Nordrhein-Westfalen, 45147, Germany
More Info
Universitaetsklinikum Koeln ( Site 1307) Köln Nordrhein-Westfalen, 50937, Germany
More Info
Johannes Wesling Klinikum Minden-Skin Cancer Center Minden ( Site 1301) Minden Nordrhein-Westfalen, 32429, Germany
More Info
Universitaetsklinikum des Saarlandes ( Site 1313) Homburg Saarland, 66424, Germany
More Info
SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1306) Gera Thuringen, 07548, Germany
More Info
Charité Universitaetsmedizin Berlin - Campus Mitte-Hauttumorcentrum Charité (HTCC) ( Site 1302) Berlin , 10115, Germany
More Info
Universitaetsklinikum Hamburg-Eppendorf ( Site 1309) Hamburg , 20246, Germany
More Info
General Hospital of Athens "Laiko"-First Department of Internal Medicine ( Site 3700) Athens Attiki, 115 2, Greece
More Info
Metropolitan Hospital-A' Oncology Dpt ( Site 3701) Neo Faliro Attiki, 185 4, Greece
More Info
Bioclinic Thessalonikis Private Clinic Single Member S.A.-Oncology ( Site 3703) Thessaloniki Kentriki Makedonia, 546 2, Greece
More Info
European Interbalkan Medical Center-Oncology Department ( Site 3702) Thessaloniki , 57001, Greece
More Info
Emek Medical Center ( Site 2003) Afula , 18341, Israel
More Info
Hadassah Medical Center ( Site 2004) Jerusalem , 91120, Israel
More Info
Rabin Medical Center ( Site 2000) Petah Tikva , 4941 , Israel
More Info
Sheba Medical Center ( Site 2001) Ramat Gan , 52656, Israel
More Info
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1401) Milan Lombardia, 20133, Italy
More Info
Azienda Ospedaliero Universitaria Senese-U.O.C. Immunoterapia Oncologica ( Site 1402) Siena Toscana, 53100, Italy
More Info
AO Santa Maria della Misericordia ( Site 1403) Perugia Umbria, 06129, Italy
More Info
Istituto Europeo di Oncologia IRCCS ( Site 1404) Milano , 20141, Italy
More Info
Istituto Nazionale Tumori IRCCS Fondazione Pascale-s.c. melanoma, immunoterapia oncologica e terapi Napoli , 80131, Italy
More Info
Capital, Coast and Hutt Valley District - Wellington Regional Hospital ( Site 1502) Newtown Wellington, 6021, New Zealand
More Info
Harbour Cancer & Wellness ( Site 1500) Auckland , 1023, New Zealand
More Info
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2908) Bydgoszcz Kujawsko-pomorskie, 85-79, Poland
More Info
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2903) Siedlce Mazowieckie, 08-11, Poland
More Info
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Warszawa Mazowieckie, 02-78, Poland
More Info
Bialostockie Centrum Onkologii ( Site 2905) Bialystok Podlaskie, 15-02, Poland
More Info
Uniwersyteckie Centrum Kliniczne-Klinika Chirurgii Onkologicznej, Transplantacyjnej i Ogólnej ( Site Gdańsk Pomorskie, 80-21, Poland
More Info
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2907) Gliwice Slaskie, 44-10, Poland
More Info
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch Kielce Swietokrzyskie, 25-73, Poland
More Info
Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 3601) Lisbon Lisboa, 1099-, Portugal
More Info
Centro Hospitalar de Lisboa Ocidental - Hospital De Sao Francisco Xavier ( Site 3602) Lisbon Lisboa, 1449-, Portugal
More Info
Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria ( Site 3603) Lisbon Lisboa, 1649-, Portugal
More Info
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 3604) Porto , 4200-, Portugal
More Info
Medical Oncology Centre of Rosebank ( Site 4106) Johannesburg Gauteng, 2196, South Africa
More Info
Wilgers Oncology Centre ( Site 4103) Pretoria Gauteng, 0040, South Africa
More Info
Cape Town Oncology Trials ( Site 4100) Cape Town Western Cape, 7570, South Africa
More Info
HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Sit Barcelona Cataluna, 08036, Spain
More Info
Hospital Universitario Ramón y Cajal ( Site 1602) Madrid Madrid, Comunidad De, 28034, Spain
More Info
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1603) Pozuelo de Alarcon Madrid, 28223, Spain
More Info
H.R.U Málaga - Hospital General-Oncology ( Site 1605) Málaga Malaga, 29011, Spain
More Info
HOSPITAL CLINICO DE VALENCIA ( Site 1604) Valencia Valenciana, Comunitat, 46010, Spain
More Info
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1601) Barcelona , 08035, Spain
More Info
Skånes Universitetssjukhus Lund ( Site 3201) Lund Skane Lan, 22185, Sweden
More Info
Sahlgrenska Universitetssjukhuset ( Site 3200) Gothenburg Vastra Gotalands Lan, 413 4, Sweden
More Info
Kantonsspital Graubünden-Medizin ( Site 1703) Chur Grisons, 7000, Switzerland
More Info
UniversitätsSpital Zürich-Dermatology ( Site 1700) Zürich Flughafen Zurich, 8058, Switzerland
More Info
Chang Gung Memorial Hospital at Kaohsiung ( Site 4000) Kaohsiung , 83301, Taiwan
More Info
National Cheng Kung University Hospital-Clinical Trial Center ( Site 4004) Tainan , 704, Taiwan
More Info
National Taiwan University Hospital ( Site 4001) Taipei , 10022, Taiwan
More Info
Chang Gung Medical Foundation-Linkou Branch ( Site 4003) Taoyuan , 333, Taiwan
More Info
I.E.U. Medical Point Hastanesi-Oncology ( Site 3005) Izmir, Karsiyaka Izmir, 00903, Turkey
More Info
Hacettepe Universite Hastaneleri ( Site 3006) Ankara , 06230, Turkey
More Info
Memorial Ankara Hastanesi-Medical Oncology ( Site 3010) Ankara , 06520, Turkey
More Info
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 3002) Ankara , 06800, Turkey
More Info
Acibadem Universitesi Atakent Hastanesi-Medical Oncology ( Site 3008) Istanbul , 34303, Turkey
More Info
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3003) Istanbul , 34722, Turkey
More Info
Bristol Haematology and Oncology Centre ( Site 1811) Bristol Bristol, City Of, BS2 8, United Kingdom
More Info
Addenbrooke's Hospital ( Site 1800) Cambridge Cambridgeshire, CB2 2, United Kingdom
More Info
Norfolk and Norwich University Hospitals NHS Foundation Trust ( Site 1813) Cringleford England, NR4 7, United Kingdom
More Info
ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 1804) London Kensington And Chelsea, SW3 6, United Kingdom
More Info
University College London Hospital ( Site 1807) London London, City Of, NW1 2, United Kingdom
More Info
Western General Hospital ( Site 1806) Edinburgh Midlothian, EH4 2, United Kingdom
More Info
The Churchill Hospital ( Site 1805) Oxford Oxfordshire, OX3 7, United Kingdom
More Info
The Christie NHS Foundation Trust ( Site 1814) Manchester , m20 4, United Kingdom
More Info How clear is this clinincal trial information?
Sign Up for SN+ Sign up now for access to powerful tools, top experts, and customized information to help you fight cancer.
Personalized content tailored to your profile and disease type Access exclusive patient guides Breaking treatment information and expert perspectives and more... Sign Up Now Already have an account? Sign In
Sign Up for SN+ Don't have an account? Sign In
Sign In to SN+ Don't have an account? Sign Up