Melanoma Clinical Trial

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

Summary

The purpose of this study is to assess the efficacy and safety of oral belzutifan (MK-6482) plus intravenous (IV) pembrolizumab (MK-3475) compared to placebo plus pembrolizumab, in the adjuvant treatment of Clear Cell Renal Cell Carcinoma (ccRCC) post nephrectomy.

The primary study hypothesis is that belzutifan plus pembrolizumab is superior to placebo plus pembrolizumab with respect to disease-free survival (DFS).

View Eligibility Criteria

Eligibility Criteria

The main inclusion and exclusion criteria include but are not limited to the following:

Inclusion Criteria:

Has a histologically or cytologically confirmed diagnosis of RCC with clear cell component per American Joint Committee on Cancer (AJCC) (8th Edition), with or without sarcomatoid features

Has intermediate-high risk, high risk, or M1 no evidence of disease (NED) RCC as defined by the following pathological tumor-node metastasis and tumor grading:

Intermediate-high risk RCC: pT2, Grade 4 or sarcomatoid, N0, M0; pT3, any grade, N0, M0
High risk RCC: pT4, any Grade N0, M0; pT any stage, any Grade, N+, M0
M1 NED RCC participants who present not only with the primary kidney tumor but also solid, isolated, soft tissue metastases that can be completely resected at one of the following: the time of nephrectomy (synchronous) or, ≤2 years from nephrectomy (metachronous)
Has undergone complete resection of the primary tumor (partial or radical nephrectomy) and complete resection of solid, isolated, soft tissue metastatic lesion(s) in M1 NED participants
Must have undergone a nephrectomy and/or metastasectomy ≤12 weeks prior to randomization
Has Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 within 10 days before randomization.
Male participants must agree to continue contraception at least 7 days after the last dose of belzutifan/placebo
Female participants of childbearing potential must be willing to use an adequate method of contraception, for the course of the study through 120 days after the last dose of pembrolizumab or at least 30 days after last dose of belzutifan/placebo, whichever occurs last
Has adequate organ function

Exclusion Criteria:

Has had a major surgery, other than nephrectomy plus resection of preexisting metastases for M1 NED participants, within 4 weeks prior to randomization
Has a pulse oximeter reading <92% at rest, requires intermittent supplemental oxygen, or requires chronic supplemental oxygen
Has clinically significant cardiovascular disease within 6 months from first dose of study intervention
Has other clinically significant disorders such as: serious active nonhealing wound/ulcer/bone fracture; requirement for hemodialysis or peritoneal dialysis
Has preexisting brain or bone metastatic lesions
Has received prior systemic therapy for RCC
Has received prior radiotherapy for RCC
Has received a live or live-attenuated vaccine within 30 days before the first dose of study intervention; administration of killed vaccines are allowed
Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
Has a known additional malignancy (other than RCC treated with nephrectomy and/or metastasectomy) that is progressing or has required active treatment within the past 3 years
Has an active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids, or immunosuppressive drugs); replacement therapy is allowed
Has a history of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease
Has an active infection, requiring systemic therapy
Has a known history of human immunodeficiency virus (HIV) infection, a known history of Hepatitis B or known active Hepatitis C virus infection
Has had an allogenic tissue/solid organ transplant

Study is for people with:

Melanoma

Phase:

Phase 3

Estimated Enrollment:

1800

Study ID:

NCT05239728

Recruitment Status:

Active, not recruiting

Sponsor:

Merck Sharp & Dohme LLC

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There are 276 Locations for this study

See Locations Near You

Mayo Clinic in Arizona - Phoenix ( Site 3554)
Phoenix Arizona, 85054, United States
City of Hope Comprehensive Cancer Center ( Site 3567)
Duarte California, 91010, United States
Moores Cancer Center-Clinical Trials Office- Genitourinary ( Site 3516)
La Jolla California, 92093, United States
UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro
Los Angeles California, 90095, United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 3518)
Orange California, 92868, United States
Stanford Cancer Center ( Site 3523)
Palo Alto California, 94304, United States
University of Colorado Anschutz Medical Campus ( Site 3514)
Aurora Colorado, 80045, United States
St. Marys Hospital and Regional Medical Center-SCL Health Cancer Centers of Colorado ( Site 3562)
Grand Junction Colorado, 81501, United States
Georgetown University Medical Center ( Site 3534)
Washington District of Columbia, 20007, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center-Cancer Research Services ( Site 35
Miami Florida, 33136, United States
Moffitt Cancer Center ( Site 3540)
Tampa Florida, 33612, United States
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 3515)
Marietta Georgia, 30060, United States
Parkview Research Center at Parkview Regional Medical Center ( Site 3526)
Fort Wayne Indiana, 46845, United States
Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center- GU Oncology ( Site 3549)
Baltimore Maryland, 21231, United States
Massachusetts General Hospital ( Site 3571)
Boston Massachusetts, 02114, United States
Beth Israel Deaconess Medical Center-Cancer Clinical Trials Office ( Site 3572)
Boston Massachusetts, 02215, United States
Dana-Farber Cancer Institute-GU ( Site 3505)
Boston Massachusetts, 02215, United States
Cancer and Hematology Centers of Western Michigan ( Site 3502)
Grand Rapids Michigan, 49503, United States
Washington University-Internal Medicine/Oncology ( Site 3531)
Saint Louis Missouri, 63110, United States
St. Vincent Frontier Cancer Center-Research ( Site 3506)
Billings Montana, 59102, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 3550)
Omaha Nebraska, 68130, United States
Englewood Hospital and Medical Center ( Site 3557)
Englewood New Jersey, 07631, United States
Rutgers Cancer Institute of New Jersey ( Site 3541)
New Brunswick New Jersey, 08903, United States
Monter Cancer Center ( Site 3560)
Lake Success New York, 11042, United States
Icahn School of Medicine at Mount Sinai ( Site 3539)
New York New York, 10029, United States
Memorial Sloan Kettering Cancer Center ( Site 3568)
New York New York, 10065, United States
University of Rochester Medical Center ( Site 3528)
Rochester New York, 14642, United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C
Columbus Ohio, 43210, United States
MidLantic urology ( Site 3501)
Bala-Cynwyd Pennsylvania, 19004, United States
Fox Chase Cancer Center-GU Oncology ( Site 3535)
Philadelphia Pennsylvania, 19111, United States
Sanford Cancer Center ( Site 3551)
Sioux Falls South Dakota, 57104, United States
The West Clinic, PLLC dba West Cancer Center ( Site 3522)
Germantown Tennessee, 38138, United States
Urology Associates ( Site 3512)
Nashville Tennessee, 37209, United States
UT Southwestern Medical Center ( Site 3529)
Dallas Texas, 75390, United States
University of Texas MD Anderson Cancer Center-Urology ( Site 3569)
Houston Texas, 77030, United States
Inova Schar Cancer Institute ( Site 3525)
Fairfax Virginia, 22031, United States
Seattle Cancer Care Alliance-Renal/Melanoma/MCC ( Site 3524)
Seattle Washington, 98109, United States
Blacktown Hospital-Blacktown Cancer and Haematology Centre - Medical Oncology ( Site 0002)
Blacktown New South Wales, 2148, Australia
Macquarie University-MQ Health Clinical Trials Unit ( Site 0003)
Macquarie University New South Wales, 2109, Australia
Tamworth Hospital-North West Cancer Centre ( Site 0006)
North Tamworth New South Wales, 2340, Australia
Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Si
Brisbane Queensland, 4029, Australia
Lyell McEwin Hospital-Oncology Clinical Trials Unit ( Site 0008)
Elizabeth Vale South Australia, 5112, Australia
Austin Health-Cancer Clinical Trials Centre ( Site 0005)
Heidelberg Victoria, 3084, Australia
Fiona Stanley Hospital-Medical Oncology ( Site 0004)
Murdoch Western Australia, 6150, Australia
Hospital São Carlos-Oncocentro Ce ( Site 0104)
Fortaleza Ceara, 60135, Brazil
Centro Avançado de Tratamento Oncológico- CENANTRON-Clinical Research ( Site 0105)
Belo Horizonte Minas Gerais, 30130, Brazil
Instituto do Câncer e Transplante de Curitiba ( Site 0102)
Curitiba Parana, 80510, Brazil
Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0103)
Natal Rio Grande Do Norte, 59075, Brazil
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0101)
Porto Alegre Rio Grande Do Sul, 91350, Brazil
Hospital de Clínicas de Ribeirão Preto ( Site 0112)
Ribeirão Preto Sao Paulo, 14048, Brazil
BP - A Beneficencia Portuguesa de São Paulo ( Site 0111)
Sao Paulo , 01321, Brazil
MBAL Uni Hospital-Department of Medical Oncology ( Site 0204)
Panagyurishte Pazardzhik, 4500, Bulgaria
MHAT Serdika-Second Department of Medical Oncology ( Site 0203)
Sofia Sofia (stolitsa), 1301, Bulgaria
Complex Cancer Center Plovdiv-First Medical Oncology Department ( Site 0205)
Plovdiv , 4004, Bulgaria
Tom Baker Cancer Center ( Site 3706)
Calgary Alberta, T2N 4, Canada
BC Cancer Vancouver-Clinical Trials Unit ( Site 3707)
Vancouver British Columbia, V5Z 4, Canada
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 3710)
Hamilton Ontario, L8V 5, Canada
Victoria Hospital & Children's Hospital - London Health Scie-London Regional Cancer Program ( Site 3
London Ontario, N6A 5, Canada
Princess Margaret Cancer Centre ( Site 3703)
Toronto Ontario, M5G 2, Canada
CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 3708)
Montreal Quebec, H1T 2, Canada
McGill University Health Centre ( Site 3709)
Montréal Quebec, H4A 3, Canada
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 3
Quebec , G1J 1, Canada
James Lind Centro de Investigación del Cáncer ( Site 0307)
Temuco Araucania, 48008, Chile
Clínica Puerto Montt ( Site 0309)
Puerto Montt Los Lagos, 55002, Chile
Oncocentro Valdivia ( Site 0312)
Valdivia Los Rios, 51121, Chile
FALP-UIDO ( Site 0302)
Santiago Region M. De Santiago, 75009, Chile
Oncovida ( Site 0306)
Santiago Region M. De Santiago, 75100, Chile
Bradfordhill ( Site 0305)
Santiago Region M. De Santiago, 84203, Chile
ONCOCENTRO APYS-ACEREY ( Site 0301)
Viña del Mar Valparaiso, 25205, Chile
Bradford Hill Norte ( Site 0303)
Antofagasta , 12400, Chile
Afflilated Hospital of Bengbu Medical College-Urology Surgery ( Site 0438)
Bengbu Anhui, 23300, China
Second Affiliated hospital of Anhui Medical University-Urology ( Site 0416)
Hefei Anhui, 23000, China
Cancer Hospital Chinese Academy of Medical Science-Urinary Surgery ( Site 0435)
Beijing Beijing, 10002, China
Peking University First Hospital-Urology ( Site 0407)
Beijing Beijing, 10003, China
Beijing Cancer hospital-Urinary Surgery ( Site 0406)
Beijing Beijing, 10014, China
First Medical Center of Chinese PLA General Hospital ( Site 0415)
Beijing Beijing, 10085, China
Chongqing University Cancer Hospital ( Site 0414)
Chongqing Chongqing, 40003, China
Army Medical Center of People's Liberation Army ( Site 0439)
Chongqing Chongqing, 40004, China
The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 0445)
Fuzhou Fujian, 35000, China
SUN YAT-SEN UNIVERSITY CANCER CENTRE-Urology Surgery ( Site 0417)
Guangzhou Guangdong, 51006, China
The First Affiliated Hospital of Guangzhou Medical University-Urology ( Site 0403)
Guangzhou Guangdong, 51012, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Urology Surgery ( Site 0402)
Guangzhou Guangdong, 51028, China
Henan Cancer Hospital-Urology ( Site 0441)
Zhengzhou Henan, 45000, China
Tongji Hospital Tongji Medical,Science & Technology-oncology ( Site 0423)
Wuhan Hubei, 43000, China
Wuhan Union Hospital ( Site 0430)
Wuhan Hubei, 43002, China
Hubei Cancer Hospital-Urinary surgery ( Site 0419)
Wuhan Hubei, 43007, China
Hunan Cancer Hospital ( Site 0421)
Changsha Hunan, 41001, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( S
NanJing Jiangsu, 21000, China
The First Affiliated Hospital of Nanchang University ( Site 0432)
Nanchang Jiangxi, 33000, China
The Second Affiliated Hospital of Nanchang University ( Site 0443)
Nanchang Jiangxi, 33000, China
The First Affiliated Hospital of Xi'an Jiaotong University ( Site 0431)
Xi'an Shaanxi, 71006, China
Fudan University Shanghai Cancer Center-Urology department ( Site 0401)
Shanghai Shanghai, 20000, China
Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 0418)
Shanghai Shanghai, 20000, China
Huadong Hospital Affiliated to Fudan University ( Site 0405)
Shanghai Shanghai, 20004, China
West China Hospital of Sichuan University-Urology Surgery ( Site 0410)
Cheng Du Sichuan, 61004, China
Tianjin Medical University Cancer Institute and Hospital ( Site 0422)
Tianjin Tianjin, 30006, China
The First Affiliated Hospital, Zhejiang University ( Site 0428)
Hangzhou Zhejiang, 31000, China
Zhejiang Provincial People's Hospital-Urology ( Site 0426)
Hangzhou Zhejiang, 31001, China
Ningbo First Hospital-Urology ( Site 0433)
Ningbo Zhejiang, 31501, China
The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 0425)
Wenzhou Zhejiang, 32500, China
Clinica de la Costa S.A.S. ( Site 0506)
Barranquilla Atlantico, 08002, Colombia
Sociedad De Oncologia Y Hematologia Del Cesar-Oncology ( Site 0505)
Valledupar Cesar, 20000, Colombia
Oncomédica S.A.S ( Site 0501)
Monteria Cordoba, 23000, Colombia
Administradora Country S.A. - Clinica del Country ( Site 0504)
Bogotá Distrito Capital De Bogota, 11022, Colombia
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0605)
Brno Brno-mesto, 656 5, Czechia
Fakultni Nemocnice u sv. Anny v Brne-Onkologicko-chirurgicke oddeleni ( Site 0603)
Brno Brno-mesto, 656 9, Czechia
Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 0606)
Ostrava Moravskoslezsky Kraj, 708 5, Czechia
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0601)
Olomouc Olomoucky Kraj, 779 0, Czechia
Fakultni Thomayerova nemocnice-Onkologicka klinika 1. LF UK ( Site 0602)
Prague Praha 4, 140 5, Czechia
Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0607)
Praha Praha 5, 150 0, Czechia
Fakultni nemocnice Hradec Kralove-Klinika onkologie a radioterapie ( Site 0604)
Hradec Kralove , 500 0, Czechia
Tampereen yliopistollinen sairaala ( Site 0805)
Tampere Pirkanmaa, 33520, Finland
Oulun yliopistollinen sairaala ( Site 0802)
Oulu Pohjois-Pohjanmaa, 90220, Finland
Kuopion Yliopistollinen Sairaala-Syöpäkeskus ( Site 0804)
Kuopio Pohjois-Savo, 70210, Finland
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 0803)
Helsinki Uusimaa, 00290, Finland
Turku University Hospital ( Site 0801)
Turku Varsinais-Suomi, 20520, Finland
Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0903)
Strasbourg Alsace, 67200, France
ROC37 ( Site 0910)
Chambray Les Tours Centre, 37170, France
CHU Besançon-Medical oncology ( Site 0904)
Besançon Doubs, 25000, France
Gustave Roussy ( Site 0907)
Villejuif Ile-de-France, 94800, France
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 0908)
Rennes Ille-et-Vilaine, 35000, France
Centre Hospitalier Universitaire d'Angers-Urology ( Site 0901)
Angers Maine-et-Loire, 49933, France
CENTRE LEON BERARD-Medical oncology ( Site 0902)
Lyon Rhone-Alpes, 69008, France
Hôpital Saint-Louis ( Site 0905)
Paris , 75010, France
Hôpital Européen Georges Pompidou-Service d'Oncologie Médicale ( Site 0906)
Paris , 75015, France
Hegau-Bodensee-Klinikum Singen ( Site 1016)
Singen Baden-Wurttemberg, 78224, Germany
Universitaetsklinikum Tuebingen ( Site 1002)
Tübingen Baden-Wurttemberg, 72076, Germany
klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Sit
Munich Bayern, 81675, Germany
Universitätsklinikum Aachen ( Site 1024)
Aachen Nordrhein-Westfalen, 52074, Germany
Universitätsklinikum Bonn ( Site 1006)
Bonn Nordrhein-Westfalen, 53127, Germany
Universitaetsklinikum Duesseldorf ( Site 1017)
Düsseldorf Nordrhein-Westfalen, 40225, Germany
Universitaetsklinikum Essen ( Site 1004)
Essen Nordrhein-Westfalen, 45147, Germany
Universitätsklinikum Münster - Albert Schweitzer Campus ( Site 1005)
Münster Nordrhein-Westfalen, 48149, Germany
Universitaetsklinikum des Saarlandes-Klinik fuer Urologie und Kinderurologies ( Site 1020)
Homburg Saarland, 66421, Germany
Krankenhaus Martha-Maria Halle-Dölau-Klinik für Urologie, Kinderurologie und urologische Onkologie (
Halle Sachsen-Anhalt, 06120, Germany
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Urologie ( Site 1021)
Dresden Sachsen, 01307, Germany
SRH Wald-Klinikum Gera ( Site 1015)
Gera Thuringen, 07548, Germany
Universitätsklinikum Jena ( Site 1007)
Jena Thuringen, 07747, Germany
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 1022)
Berlin , 10117, Germany
Helios Klinikum Berlin-Buch ( Site 1011)
Berlin , 13125, Germany
Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 1001)
Hamburg , 20246, Germany
Alexandra Hospital-ONCOLOGY DEPT. ( Site 1102)
Athens Attiki, 115 2, Greece
Metropolitan Hospital-2nd Oncology Dept ( Site 1104)
Athens Attiki, 185 4, Greece
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1101)
Chaidari Attiki, 124 6, Greece
Euromedica General Clinic Thessaloniki-Oncology Unit ( Site 1103)
Thessaloniki , 546 4, Greece
European Interbalkan Medical Center-Oncology Department ( Site 1105)
Thessaloniki , 57001, Greece
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ( Site 1319)
Szeged Csongrad, 6725, Hungary
Petz Aladar Egyetemi Oktato Korhaz-Onkológiai Osztály ( Site 1321)
Gyor Gyor-Moson-Sopron, 9024, Hungary
Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 1316)
Budapest Pest, 1122, Hungary
Somogy Megyei Kaposi Mór Oktató Kórház-Oncology center ( Site 1311)
Kaposvár Somogy, 7400, Hungary
Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 1310)
Debrecen , 4032, Hungary
Tallaght University Hospital ( Site 1402)
Dublin 24 Dublin, D24 N, Ireland
St. Vincent's University Hospital ( Site 1401)
Dublin 4 Dublin, , Ireland
Cork University Hospital ( Site 1404)
Cork , T12 E, Ireland
Beaumont Hospital, Dublin-Cancer Clinical Trials & Research Unit ( Site 1403)
Dublin , Dubli, Ireland
Soroka Medical Center ( Site 1505)
Be'er Sheva , 84101, Israel
Rambam Health Care Campus-Oncology ( Site 1502)
Haifa , 31096, Israel
Hadassah Medical Center-Oncology ( Site 1506)
Jerusalem , 91120, Israel
Rabin Medical Center-Oncology ( Site 1503)
Petah-Tikva , 49414, Israel
Sheba Medical Center-ONCOLOGY ( Site 1504)
Ramat Gan , 52656, Israel
Sourasky Medical Center-Oncology ( Site 1501)
Tel Aviv , 64239, Israel
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 1603)
Meldola Emilia-Romagna, 47014, Italy
Fondazione Policlinico Universitario Agostino Gemelli-Medical Oncology ( Site 1604)
Roma Lazio, 00168, Italy
Ospedale San Raffaele-Oncologia Medica ( Site 1606)
Milano Lombardia, 20132, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1608)
Milan Lombardia, 20133, Italy
Azienda Sanitaria Ospedaliera S Luigi Gonzaga-SCDU Oncologia Medica ( Site 1602)
Orbassano Piemonte, 10043, Italy
A.O.U.C. Policlinico di Bari ( Site 1607)
Bari Puglia, 70124, Italy
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1601)
Firenze Toscana, 50134, Italy
Azienda USL 8 di Arezzo-Medical Oncology ( Site 1610)
Arezzo , 52100, Italy
IRCCS - AOU di Bologna-Oncologia Medica Ardizzoni ( Site 1605)
Bologna , 40138, Italy
Azienda Ospedaliera Santa Maria Terni-SC Oncologia ( Site 1609)
Terni , 05100, Italy
Fujita Health University ( Site 1709)
Toyoake Aichi, 470-1, Japan
National Cancer Center Hospital East ( Site 1704)
Kashiwa Chiba, 277-8, Japan
Toho University Sakura Medical Center ( Site 1718)
Sakura Chiba, 285-8, Japan
Ehime University Hospital ( Site 1714)
Toon Ehime, 791-0, Japan
Sapporo Medical University Hospital ( Site 1702)
Sapporo Hokkaido, 060-8, Japan
Hokkaido University Hospital ( Site 1701)
Sapporo Hokkaido, 060-8, Japan
Kanagawa cancer center ( Site 1703)
Yokohama Kanagawa, 241-8, Japan
Nara Medical University Hospital ( Site 1712)
Kashihara Nara, 634-0, Japan
Bell Land General Hospital ( Site 1710)
Sakai Osaka, 599-8, Japan
Osaka University Hospital ( Site 1711)
Suita Osaka, 565-0, Japan
Hamamatsu University Hospital ( Site 1708)
Hamamatsu Shizuoka, 431-3, Japan
Toranomon Hospital ( Site 1706)
Minato-ku Tokyo, 105-8, Japan
Toyama University Hospital ( Site 1713)
Toyoma Toyama, 930-0, Japan
Kyushu University Hospital ( Site 1715)
Fukuoka , 812-8, Japan
Kagoshima University Hospital ( Site 1719)
Kagoshima , 890-8, Japan
Kumamoto University ( Site 1716)
Kumamoto , 860-8, Japan
Okayama University Hospital ( Site 1720)
Okayama , 700-8, Japan
Nippon Medical School Hospital ( Site 1705)
Tokyo , 113-8, Japan
Tokyo Women's Medical University Adachi Medical Center ( Site 1717)
Tokyo , 123-8, Japan
Keio university hospital ( Site 1707)
Tokyo , 160-8, Japan
Wakayama Medical University Hospital ( Site 1721)
Wakayama , 641-8, Japan
National Cancer Center-Center for Urologic Cancer ( Site 2604)
Goyang-si Kyonggi-do, 10408, Korea, Republic of
Seoul National University Bundang Hospital-Urology ( Site 2602)
Seongnam Kyonggi-do, 13620, Korea, Republic of
Asan Medical Center-Oncology ( Site 2601)
Songpagu Seoul, 05505, Korea, Republic of
Samsung Medical Center ( Site 2603)
Seoul , 06351, Korea, Republic of
University Malaya Medical Centre ( Site 1804)
Lembah Pantai Kuala Lumpur, 59100, Malaysia
Hospital Pulau Pinang ( Site 1806)
George Town Pulau Pinang, 10450, Malaysia
Sarawak General Hospital-Radiotherapy Unit ( Site 1805)
Kuching Sarawak, 93586, Malaysia
INSTITUTO NACIONAL DE CANCEROLOGIA ( Site 1902)
Mexico City Distrito Federal, 14070, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran-Oncologia y Hematologia ( Site 1
Mexico City Distrito Federal, 14080, Mexico
Terapias Integrales del Riñon SA de CV ( Site 1910)
Guadalajara Jalisco, 44260, Mexico
Hospital Civil Fray Antonio Alcalde-Oncology ( Site 1906)
Guadalajara Jalisco, 44280, Mexico
BRCR Global Mexico - Guadalajara-Research ( Site 1908)
Guadalajara Jalisco, , Mexico
Filios Alta Medicina ( Site 1903)
Monterrey Nuevo Leon, 64460, Mexico
iCan Oncology Center Centro Medico AVE ( Site 1901)
Monterrey Nuevo Leon, 64710, Mexico
Hospital H+ Queretaro-Cuidados Oncológicos ( Site 1905)
Santiago de Queretaro Queretaro, 76000, Mexico
BRCR Global Mexico - Queretaro-SMIQ ( Site 1907)
Santiago de Querétaro Queretaro, 76070, Mexico
Centro de Oncología Personalizada ( Site 1911)
Culiacán Sinaloa, 80040, Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 1904)
Oaxaca , 68020, Mexico
Oncocenter ( Site 1909)
Puebla , 72530, Mexico
Ziekenhuis Rijnstate-Rijnstate Centrum Oncologisch Onderzoek ( Site 3113)
Arnhem Gelderland, 6815 , Netherlands
Radboudumc ( Site 3120)
Nijmegen Gelderland, 6525 , Netherlands
Maastricht UMC+ ( Site 3104)
Maastricht Limburg, 6229 , Netherlands
Amphia Ziekenhuis, locatie Breda Molengracht ( Site 3103)
Breda Noord-Brabant, 4818 , Netherlands
Maxima Medisch Centrum, locatie Eindhoven ( Site 3116)
Eindhoven Noord-Brabant, 5600 , Netherlands
Amsterdam UMC, locatie AMC ( Site 3105)
Amsterdam Noord-Holland, 1105 , Netherlands
Tergooiziekenhuizen, locatie Hilversum ( Site 3102)
Hilversum Noord-Holland, 1213 , Netherlands
Spaarne Gasthuis - Hoofddorp-Oncology ( Site 3107)
Hoofddorp Noord-Holland, 2134 , Netherlands
Isala, locatie Zwolle-Oncology ( Site 3111)
Zwolle Overijssel, 8025 , Netherlands
Haga Ziekenhuis locatie Leyweg-Oncology ( Site 3108)
Den Haag Zuid-Holland, 2545 , Netherlands
Haaglanden MC - locatie Antoniushove ( Site 3117)
Leidschendam Zuid-Holland, 2501 , Netherlands
Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 3101)
Schiedam Zuid-Holland, 3118 , Netherlands
University Medical Center Groningen ( Site 3121)
Groningen , 9700R, Netherlands
St. Antonius Ziekenhuis, locatie Utrecht-Interne geneeskunde ( Site 3112)
Utrecht , 3543 , Netherlands
Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 3106)
Utrecht , 3584 , Netherlands
Auckland City Hospital-Cancer & Blood Research ( Site 2003)
Auckland , 1023, New Zealand
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu ( Site 2309)
Wrocław Dolnoslaskie, 50-55, Poland
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2307)
Bydgoszcz Kujawsko-pomorskie, 85-79, Poland
MICS Centrum Medyczne Torun ( Site 2305)
Torun Kujawsko-pomorskie, 87-10, Poland
Szpital Wojewódzki im. Świętego Lukasza SP ZOZ w Tarnowie ( Site 2311)
Tarnow Malopolskie, 33-10, Poland
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2313)
Siedlce Mazowieckie, 08-11, Poland
Luxmed Onkologia sp. z o. o. ( Site 2303)
Warszawa Mazowieckie, 01-74, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (
Warszawa Mazowieckie, 02-78, Poland
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2306)
Przemysl Podkarpackie, 37-70, Poland
Przychodnia Lekarska KOMED ( Site 2304)
Konin Wielkopolskie, 62-50, Poland
Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu M-chemotherapy department ( Site 2312)
Poznań Wielkopolskie, 60-56, Poland
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 2302)
Koszalin Zachodniopomorskie, 75-58, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne ( Site 2315)
Szczecin Zachodniopomorskie, 71-43, Poland
Centrul medical Focus ( Site 2407)
București Bucuresti, 02254, Romania
Cardiomed SRL Cluj-Napoca ( Site 2406)
Cluj-Napoca Cluj, 40001, Romania
Amethyst Radiotherapy Center-Oncologie Medicala ( Site 2405)
Florești Cluj, 40728, Romania
Centrul de Oncologie "Sfântul Nectarie"-Medical Oncology ( Site 2401)
Craiova Dolj, 20074, Romania
Radiology Therapeutic Center-Oncology ( Site 2404)
Otopeni Ilfov, 07510, Romania
Cabinet Medical Oncomed ( Site 2403)
Timișoara Timis, 30023, Romania
National Cancer Centre Singapore ( Site 3601)
Singapore Central Singapore, 16858, Singapore
National University Hospital ( Site 3602)
Singapore South West, 11907, Singapore
Institut Català d'Oncologia (ICO) - Girona ( Site 2707)
Girona Gerona, 17007, Spain
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2710)
Madrid Madrid, Comunidad De, 28034, Spain
Hospital Universitario 12 de Octubre-Medical Oncology ( Site 2708)
Madrid Madrid, Comunidad De, 28041, Spain
Fundación Instituto Valenciano de Oncología ( Site 2705)
Valencia Valenciana, Comunitat, 46009, Spain
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2702)
Barcelona , 08035, Spain
Hospital Lucus Augusti-Oncology ( Site 2706)
Lugo , 27003, Spain
Hospital Clinico San Carlos-Oncology Department ( Site 2703)
Madrid , 28040, Spain
Hospital Universitario Virgen de la Victoria-Phase II-III-IV Trials ( Site 2709)
Malaga , 29010, Spain
Karolinska Universitetssjukhuset Solna ( Site 2802)
Stockholm Stockholms Lan, 171 7, Sweden
Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 2803)
Uppsala Uppsala Lan, 751 8, Sweden
Sahlgrenska Universitetssjukhuset ( Site 2801)
Gothenburg Vastra Gotalands Lan, 413 4, Sweden
Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 2905)
Kaohsiung Niao Sung Dist Kaohsiung, 83301, Taiwan
Tri-Service General Hospital ( Site 2908)
Taipei City Taipei, 114, Taiwan
Kaohsiung Veterans General Hospital ( Site 2901)
Kaohsiung , 81362, Taiwan
China Medical University Hospital-Department of Urology ( Site 2907)
Taichung , 40447, Taiwan
Taichung Veterans General Hospital ( Site 2902)
Taichung , 407, Taiwan
National Taiwan University Hospital ( Site 2904)
Taipei , 10022, Taiwan
Taipei Veterans General Hospital ( Site 2903)
Taipei , 112, Taiwan
Chang Gung Medical Foundation-Linkou Branch-Urology ( Site 2906)
Taoyuan , 333, Taiwan
Chulalongkorn University ( Site 3005)
Bangkok Krung Thep Maha Nakhon, 10330, Thailand
Ramathibodi Hospital ( Site 3001)
Bangkok Krung Thep Maha Nakhon, 10400, Thailand
Faculty of Medicine Siriraj Hospital ( Site 3002)
Bangkok Krung Thep Maha Nakhon, 10700, Thailand
Songklanagarind hospital ( Site 3004)
Hatyai Songkhla, 90110, Thailand
Ankara Bilkent Şehir Hastanesi-oncology ( Site 3206)
Yenimahalle Ankara, 06200, Turkey
Istanbul Universitesi Cerrahpasa-Internal Diseases ( Site 3204)
Istanbul- Fatih Istanbul, 34098, Turkey
Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 3208)
Adana , 01250, Turkey
Ankara Gülhane Eitim ve Aratrma Hastanesi-Oncology ( Site 3207)
Ankara , 06010, Turkey
Ankara University Hospital Cebeci ( Site 3209)
Ankara , 06100, Turkey
Hacettepe Universitesi-oncology hospital ( Site 3203)
Ankara , 06230, Turkey
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3201)
Istanbul , 34722, Turkey
Ege University Medicine of Faculty-Medical Oncology ( Site 3202)
Izmir , 35100, Turkey
Royal Free Hospital ( Site 3304)
London England, NW32Q, United Kingdom
The Christie NHS Foundation Trust ( Site 3301)
Manchester England, M20 4, United Kingdom
City Hospital, Nottingham University Hospitals ( Site 3303)
Nottingham England, NG5 1, United Kingdom
Beatson West of Scotland Cancer Centre-Clinical Trials Unit ( Site 3305)
Glasgow Glasgow City, G12 0, United Kingdom
Charing Cross Hospital ( Site 3302)
London Hammersmith And Fulham, W6 8R, United Kingdom
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3307)
London London, City Of, EC1A , United Kingdom
Singleton Hospital ( Site 3306)
Swansea Wales, SA2 8, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Melanoma

Phase:

Phase 3

Estimated Enrollment:

1800

Study ID:

NCT05239728

Recruitment Status:

Active, not recruiting

Sponsor:


Merck Sharp & Dohme LLC

How clear is this clinincal trial information?

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