Effect of Intravitreal Ranibizumab on Radiation Retinopathy Following Plaque Brachytherapy for Choroidal Melanoma

Inclusion Criteria:

Diagnosis of radiation retinopathy
History of choroidal melanoma status post plaque brachytherapy
Age > 21 years
Ability to perform written consent and comply with study assessments for the full duration of the study

Exclusion Criteria:

Pregnancy or lactation, pre-menopausal women not using contraception
Participation in another simultaneous medical investigation or trial
Patient with significantly compromised visual acuity in the study eye due to concomitant ocular conditions.
Patients who have undergone intraocular surgery within last 60 days.
Patients who have had intravitreal anti-VEGF treatment within 45 days.
Patients who have had intravitreal triamcinolone acetonide within 4 months.
Patients who have had laser within 60 days.
Inability to obtain photographs to document CNV (including difficulty with venous access).
Patient has a history of any medical condition which would preclude scheduled visits or completion of study.
Aphakia or absence of the posterior capsule in the study eye. Previous violation of the posterior capsule in the study eye is also excluded unless as a result of yttrium aluminum garnet (YAG) posterior capsulotomy in association with posterior chamber lens implantation..
History of glaucoma filtering surgery in the study eye.
Concurrent use of more than two therapies for glaucoma.
Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated