Melanoma Clinical Trial

Pembrolizumab in Treating Patients With Desmoplastic Melanoma That Can or Cannot Be Removed by Surgery

Summary

This pilot phase II trial studies how well pembrolizumab works in treating patients with desmoplastic melanoma (DM) that can be removed by surgery (resectable) or cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

View Full Description

Full Description

PRIMARY OBJECTIVES:

I. To evaluate the pathologic complete response rate (pCR) in patients with resectable desmoplastic melanoma treated with neoadjuvant pembrolizumab (MK-3475). (Cohort A) II. To evaluate the complete response rate (confirmed and unconfirmed) in patients with unresectable desmoplastic melanoma treated with pembrolizumab (MK-3475). (Cohort B)

SECONDARY OBJECTIVES:

I. To estimate the 9 week response rate (RR) (unconfirmed complete and partial responses) among patients with measurable disease. (Cohort A) II. To estimate the median overall survival (OS). (Cohort A) III. To evaluate safety and tolerability of pembrolizumab (MK-3475) in the neoadjuvant setting. (Cohort A) IV. To estimate the median progression-free survival (PFS). (Cohort B) V. To estimate the median overall survival (OS). (Cohort B) VI. To evaluate safety and tolerability of pembrolizumab (MK-3475) in this setting. (Cohort B)

OTHER OBJECTIVES:

I. To evaluate the hypothesis that higher mutational load in the patient derived baseline tumor biopsy samples is associated with higher pathologic complete response (pCR).

II. To evaluate T cell infiltration into the tumors and circulating tumor deoxyribonucleic acid (DNA) profile from blood samples in DM patients and correlate with response to programmed cell death protein 1 (PD-1) blockade.

III. To evaluate the clonality of tumor infiltrating T cells in DM patients and correlate with response to PD-1 blockade.

IV. To evaluate adaptive immune resistant mechanism in DM tumors.

OUTLINE: Patients are assigned to 1 of 2 cohorts.

COHORT A: Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1. Treatment repeats every 21 days for up to 3 cycles. Patients with potentially resectable disease undergo surgery. Patients with tumor progression and unresectable disease may receive one additional cycle of pembrolizumab.

COHORT B: Patients with unresectable disease receive pembrolizumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 34 cycles in the absence of disease progression or toxicity.

After completion of study treatment, patients are followed up at 6 and 12 weeks, then every 3 months for 1 year, and every 6 months for 4 years.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

COHORT A: Patients must have histologically or cytologically confirmed primary desmoplastic melanoma that is deemed resectable; the decision to perform surgery on patients must be based on good clinical judgment; eligible patients for surgical resection must have disease that, in the judgment of the surgeon, is deemed completely resectable resulting in free surgical margins; patients must have residual disease after initial biopsy which can be measurable or non-measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; residual disease can either be confirmed with fine-needle aspiration (FNA) or if measurable disease is present, no FNA needs to be obtained OR
COHORT B: Patients must have histologically or cytologically confirmed primary desmoplastic melanoma that is unresectable; patients in Cohort B must have measurable disease per RECIST 1.1
Contrast-enhanced computed tomography (CT) scans of the chest, abdomen and pelvis are required; a whole body positron emission tomography (PET)/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the chest, abdomen and pelvis; imaging of the head and neck is required only if the patient has a head/neck primary; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; if skin lesions are being followed as measurable disease, photograph with a ruler included and physician measurements, must be kept in the patient's chart as source documentation; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the baseline tumor assessment form (RECIST 1.1)
Patients may have received prior surgery; all adverse events associated with prior surgery must have resolved to =< grade 1 (per Common Terminology Criteria for Adverse Events [CTCAE] 4.0) prior to registration
Patients must be >= 18 years of age
Absolute neutrophil count (ANC) >= 1,500/mcl (obtained within 28 days prior to registration)
Platelets >= 50,000/mcl (obtained within 28 days prior to registration)
Hemoglobin >= 8 g/dL (obtained within 28 days prior to registration)
Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 3.0 x IULN with Gilbert's syndrome) (obtained within 28 days prior to registration)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases) (obtained within 28 days prior to registration)
Patients must have lactate dehydrogenase (LDH) performed within 28 days prior to registration
Patients must have Zubrod performance status =< 2
Patients known to be human immunodeficiency virus (HIV) positive prior to registration are eligible if they meet the following criteria within 30 days prior to registration: stable and adequate CD4 counts (>= 350 mm^3), and serum HIV viral load of < 25,000 IU/ml; patients must be on a stable anti-viral therapy
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, adequately treated in situ cancer, adequately treated stage I or II cancer (including multiple primary melanomas) from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years
Women of childbearing potential must have a negative urine or serum pregnancy test within 28 days prior to registration; women/men of reproductive potential must have agreed to use an effective contraceptive method for the course of the study through 120 days after the last dose of study medication; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy, or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures; patients must not be pregnant or nursing due to unknown teratogenic side effects
Patients must have specimens available and institutions must be planning to submit for centralized pathology review and for integrated translational medicine objectives
Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
As a part of the Oncology Patient Enrollment Network (OPEN) registration process, the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Exclusion Criteria:

Patients must not have known brain metastases unless brain metastases have been treated and patient is asymptomatic with no residual neurological dysfunction and has not received enzyme-reducing anti-epileptic drugs or corticosteroids for at least 14 days prior to registration
Patients must not have received prior systemic treatment for this melanoma
Patients must not be planning to receive concomitant other biologic therapy, hormonal therapy, other chemotherapy, anti-cancer surgery or other anti-cancer therapy while on this protocol
Patients must not have received radiation therapy, non-cytotoxic agents or investigational agents or systemic corticosteroids within 14 days prior to registration
Patients must not have history of (non-infectious) pneumonitis that required steroids or current pneumonitis
Patients must not have an active infection requiring systemic therapy
Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
Patients must not have received live vaccines within 42 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed

Study is for people with:

Melanoma

Phase:

Phase 2

Estimated Enrollment:

56

Study ID:

NCT02775851

Recruitment Status:

Active, not recruiting

Sponsor:

National Cancer Institute (NCI)

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 246 Locations for this study

See Locations Near You

Fairbanks Memorial Hospital
Fairbanks Alaska, 99701, United States
Cancer Center at Saint Joseph's
Phoenix Arizona, 85004, United States
Mercy Hospital Fort Smith
Fort Smith Arkansas, 72903, United States
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs Arkansas, 71913, United States
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande California, 93420, United States
City of Hope Comprehensive Cancer Center
Duarte California, 91010, United States
Epic Care-Dublin
Dublin California, 94568, United States
Bay Area Breast Surgeons Inc
Emeryville California, 94608, United States
Epic Care Partners in Cancer Care
Emeryville California, 94608, United States
Los Angeles County-USC Medical Center
Los Angeles California, 90033, United States
USC / Norris Comprehensive Cancer Center
Los Angeles California, 90033, United States
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles California, 90095, United States
Contra Costa Regional Medical Center
Martinez California, 94553, United States
USC Norris Oncology/Hematology-Newport Beach
Newport Beach California, 92663, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland California, 94609, United States
Bay Area Tumor Institute
Oakland California, 94609, United States
Keck Medical Center of USC Pasadena
Pasadena California, 91105, United States
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo California, 93401, United States
Mission Hope Medical Oncology - Santa Maria
Santa Maria California, 93444, United States
City of Hope South Pasadena
South Pasadena California, 91030, United States
City of Hope Upland
Upland California, 91786, United States
Epic Care Cyberknife Center
Walnut Creek California, 94597, United States
Rocky Mountain Cancer Centers-Aurora
Aurora Colorado, 80012, United States
The Medical Center of Aurora
Aurora Colorado, 80012, United States
Boulder Community Hospital
Boulder Colorado, 80301, United States
Boulder Community Foothills Hospital
Boulder Colorado, 80303, United States
Rocky Mountain Cancer Centers-Boulder
Boulder Colorado, 80304, United States
Rocky Mountain Cancer Centers - Centennial
Centennial Colorado, 80112, United States
Penrose-Saint Francis Healthcare
Colorado Springs Colorado, 80907, United States
Rocky Mountain Cancer Centers-Penrose
Colorado Springs Colorado, 80907, United States
Cancer Center of Colorado at Sloan's Lake
Denver Colorado, 80204, United States
National Jewish Health-Main Campus
Denver Colorado, 80206, United States
The Women's Imaging Center
Denver Colorado, 80209, United States
Porter Adventist Hospital
Denver Colorado, 80210, United States
Colorado Blood Cancer Institute
Denver Colorado, 80218, United States
Presbyterian - Saint Lukes Medical Center - Health One
Denver Colorado, 80218, United States
Rocky Mountain Cancer Centers-Midtown
Denver Colorado, 80218, United States
SCL Health Saint Joseph Hospital
Denver Colorado, 80218, United States
Rocky Mountain Cancer Centers-Rose
Denver Colorado, 80220, United States
Rose Medical Center
Denver Colorado, 80220, United States
Western Surgical Care
Denver Colorado, 80220, United States
Mercy Medical Center
Durango Colorado, 81301, United States
Southwest Oncology PC
Durango Colorado, 81301, United States
Mountain Blue Cancer Care Center - Swedish
Englewood Colorado, 80113, United States
Swedish Medical Center
Englewood Colorado, 80113, United States
National Jewish Health-Western Hematology Oncology
Golden Colorado, 80401, United States
Saint Mary's Hospital and Regional Medical Center
Grand Junction Colorado, 81501, United States
Grand Valley Oncology
Grand Junction Colorado, 81505, United States
North Colorado Medical Center
Greeley Colorado, 80631, United States
Good Samaritan Medical Center
Lafayette Colorado, 80026, United States
Saint Anthony Hospital
Lakewood Colorado, 80228, United States
Rocky Mountain Cancer Centers-Littleton
Littleton Colorado, 80120, United States
Littleton Adventist Hospital
Littleton Colorado, 80122, United States
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree Colorado, 80124, United States
Sky Ridge Medical Center
Lone Tree Colorado, 80124, United States
Longmont United Hospital
Longmont Colorado, 80501, United States
Rocky Mountain Cancer Centers-Longmont
Longmont Colorado, 80501, United States
McKee Medical Center
Loveland Colorado, 80539, United States
Parker Adventist Hospital
Parker Colorado, 80138, United States
Saint Mary Corwin Medical Center
Pueblo Colorado, 81004, United States
National Jewish Health-Northern Hematology Oncology
Thornton Colorado, 80260, United States
SCL Health Lutheran Medical Center
Wheat Ridge Colorado, 80033, United States
Hartford Hospital
Hartford Connecticut, 06102, United States
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura Florida, 33180, United States
Holy Cross Hospital
Fort Lauderdale Florida, 33308, United States
Mount Sinai Medical Center
Miami Beach Florida, 33140, United States
Moffitt Cancer Center-International Plaza
Tampa Florida, 33607, United States
Moffitt Cancer Center - McKinley Campus
Tampa Florida, 33612, United States
Moffitt Cancer Center
Tampa Florida, 33612, United States
Low Country Cancer Care
Savannah Georgia, 31404, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah Georgia, 31405, United States
Summit Cancer Care-Candler
Savannah Georgia, 31405, United States
Saint Alphonsus Cancer Care Center-Boise
Boise Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell Idaho, 83605, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene Idaho, 83814, United States
Walter Knox Memorial Hospital
Emmett Idaho, 83617, United States
Idaho Urologic Institute-Meridian
Meridian Idaho, 83642, United States
Saint Alphonsus Medical Center-Nampa
Nampa Idaho, 83686, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls Idaho, 83854, United States
Kootenai Cancer Clinic
Sandpoint Idaho, 83864, United States
Saint Anthony's Health
Alton Illinois, 62002, United States
Rush - Copley Medical Center
Aurora Illinois, 60504, United States
Northwestern University
Chicago Illinois, 60611, United States
Carle on Vermilion
Danville Illinois, 61832, United States
Carle Physician Group-Effingham
Effingham Illinois, 62401, United States
Northwestern Medicine Cancer Center Delnor
Geneva Illinois, 60134, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest Illinois, 60045, United States
Carle Physician Group-Mattoon/Charleston
Mattoon Illinois, 61938, United States
Good Samaritan Regional Health Center
Mount Vernon Illinois, 62864, United States
Carle Cancer Center
Urbana Illinois, 61801, United States
The Carle Foundation Hospital
Urbana Illinois, 61801, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville Illinois, 60555, United States
Rush-Copley Healthcare Center
Yorkville Illinois, 60560, United States
Deaconess Clinic Downtown
Evansville Indiana, 47713, United States
Chancellor Center for Oncology
Newburgh Indiana, 47630, United States
Medical Oncology and Hematology Associates-West Des Moines
Clive Iowa, 50325, United States
Mercy Cancer Center-West Lakes
Clive Iowa, 50325, United States
Alegent Health Mercy Hospital
Council Bluffs Iowa, 51503, United States
Greater Regional Medical Center
Creston Iowa, 50801, United States
Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States
Mission Cancer and Blood - Laurel
Des Moines Iowa, 50314, United States
Mercy Medical Center-West Lakes
West Des Moines Iowa, 50266, United States
Coffeyville Regional Medical Center
Coffeyville Kansas, 67337, United States
University of Kansas Clinical Research Center
Fairway Kansas, 66205, United States
Central Care Cancer Center - Garden City
Garden City Kansas, 67846, United States
Central Care Cancer Center - Great Bend
Great Bend Kansas, 67530, United States
HaysMed University of Kansas Health System
Hays Kansas, 67601, United States
University of Kansas Cancer Center-West
Kansas City Kansas, 66112, United States
University of Kansas Cancer Center
Kansas City Kansas, 66160, United States
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States
Kansas Institute of Medicine Cancer and Blood Center
Lenexa Kansas, 66219, United States
Minimally Invasive Surgery Hospital
Lenexa Kansas, 66219, United States
Olathe Health Cancer Center
Olathe Kansas, 66061, United States
Menorah Medical Center
Overland Park Kansas, 66209, United States
University of Kansas Cancer Center-Overland Park
Overland Park Kansas, 66210, United States
Ascension Via Christi - Pittsburg
Pittsburg Kansas, 66762, United States
Salina Regional Health Center
Salina Kansas, 67401, United States
University of Kansas Health System Saint Francis Campus
Topeka Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood Kansas, 66205, United States
Flaget Memorial Hospital
Bardstown Kentucky, 40004, United States
Commonwealth Cancer Center-Corbin
Corbin Kentucky, 40701, United States
Saint Joseph Radiation Oncology Resource Center
Lexington Kentucky, 40504, United States
Saint Joseph Hospital East
Lexington Kentucky, 40509, United States
Saint Joseph London
London Kentucky, 40741, United States
Jewish Hospital
Louisville Kentucky, 40202, United States
Saints Mary and Elizabeth Hospital
Louisville Kentucky, 40215, United States
UofL Health Medical Center Northeast
Louisville Kentucky, 40245, United States
Jewish Hospital Medical Center South
Shepherdsville Kentucky, 40165, United States
Henry Ford Cancer Institute-Downriver
Brownstown Michigan, 48183, United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township Michigan, 48038, United States
Henry Ford Medical Center-Fairlane
Dearborn Michigan, 48126, United States
Henry Ford Hospital
Detroit Michigan, 48202, United States
Allegiance Health
Jackson Michigan, 49201, United States
Monroe Cancer Center
Monroe Michigan, 48162, United States
Henry Ford Medical Center-Columbus
Novi Michigan, 48377, United States
Henry Ford Macomb Health Center - Shelby Township
Shelby Michigan, 48315, United States
Henry Ford West Bloomfield Hospital
West Bloomfield Michigan, 48322, United States
Fairview Ridges Hospital
Burnsville Minnesota, 55337, United States
Minnesota Oncology - Burnsville
Burnsville Minnesota, 55337, United States
Cambridge Medical Center
Cambridge Minnesota, 55008, United States
Mercy Hospital
Coon Rapids Minnesota, 55433, United States
Fairview Southdale Hospital
Edina Minnesota, 55435, United States
Unity Hospital
Fridley Minnesota, 55432, United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove Minnesota, 55369, United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood Minnesota, 55109, United States
Saint John's Hospital - Healtheast
Maplewood Minnesota, 55109, United States
Abbott-Northwestern Hospital
Minneapolis Minnesota, 55407, United States
Hennepin County Medical Center
Minneapolis Minnesota, 55415, United States
Health Partners Inc
Minneapolis Minnesota, 55454, United States
Monticello Cancer Center
Monticello Minnesota, 55362, United States
New Ulm Medical Center
New Ulm Minnesota, 56073, United States
Fairview Northland Medical Center
Princeton Minnesota, 55371, United States
North Memorial Medical Health Center
Robbinsdale Minnesota, 55422, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park Minnesota, 55416, United States
Regions Hospital
Saint Paul Minnesota, 55101, United States
United Hospital
Saint Paul Minnesota, 55102, United States
Saint Francis Regional Medical Center
Shakopee Minnesota, 55379, United States
Lakeview Hospital
Stillwater Minnesota, 55082, United States
Ridgeview Medical Center
Waconia Minnesota, 55387, United States
Rice Memorial Hospital
Willmar Minnesota, 56201, United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury Minnesota, 55125, United States
Fairview Lakes Medical Center
Wyoming Minnesota, 55092, United States
Singing River Hospital
Pascagoula Mississippi, 39581, United States
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin Missouri, 63011, United States
Central Care Cancer Center - Bolivar
Bolivar Missouri, 65613, United States
Cox Cancer Center Branson
Branson Missouri, 65616, United States
Centerpoint Medical Center LLC
Independence Missouri, 64057, United States
Freeman Health System
Joplin Missouri, 64804, United States
Mercy Hospital Joplin
Joplin Missouri, 64804, United States
Truman Medical Centers
Kansas City Missouri, 64108, United States
The University of Kansas Cancer Center-South
Kansas City Missouri, 64131, United States
Research Medical Center
Kansas City Missouri, 64132, United States
University of Kansas Cancer Center - North
Kansas City Missouri, 64154, United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit Missouri, 64064, United States
Delbert Day Cancer Institute at PCRMC
Rolla Missouri, 65401, United States
Mercy Clinic-Rolla-Cancer and Hematology
Rolla Missouri, 65401, United States
Heartland Regional Medical Center
Saint Joseph Missouri, 64506, United States
Saint Louis Cancer and Breast Institute-South City
Saint Louis Missouri, 63109, United States
Mercy Hospital South
Saint Louis Missouri, 63128, United States
Mercy Hospital Saint Louis
Saint Louis Missouri, 63141, United States
Mercy Hospital Springfield
Springfield Missouri, 65804, United States
CoxHealth South Hospital
Springfield Missouri, 65807, United States
Mercy Hospital Washington
Washington Missouri, 63090, United States
Community Hospital of Anaconda
Anaconda Montana, 59711, United States
Billings Clinic Cancer Center
Billings Montana, 59101, United States
Saint Vincent Healthcare
Billings Montana, 59101, United States
Saint Vincent Frontier Cancer Center
Billings Montana, 59102, United States
Bozeman Deaconess Hospital
Bozeman Montana, 59715, United States
Saint James Community Hospital and Cancer Treatment Center
Butte Montana, 59701, United States
Benefis Healthcare- Sletten Cancer Institute
Great Falls Montana, 59405, United States
Great Falls Clinic
Great Falls Montana, 59405, United States
Saint Peter's Community Hospital
Helena Montana, 59601, United States
Kalispell Regional Medical Center
Kalispell Montana, 59901, United States
Community Medical Hospital
Missoula Montana, 59804, United States
CHI Health Saint Francis
Grand Island Nebraska, 68803, United States
CHI Health Good Samaritan
Kearney Nebraska, 68847, United States
Saint Elizabeth Regional Medical Center
Lincoln Nebraska, 68510, United States
Alegent Health Immanuel Medical Center
Omaha Nebraska, 68122, United States
Alegent Health Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States
Alegent Health Lakeside Hospital
Omaha Nebraska, 68130, United States
Creighton University Medical Center
Omaha Nebraska, 68131, United States
Midlands Community Hospital
Papillion Nebraska, 68046, United States
Roswell Park Cancer Institute
Buffalo New York, 14263, United States
Southeastern Medical Oncology Center-Clinton
Clinton North Carolina, 28328, United States
Southeastern Medical Oncology Center-Goldsboro
Goldsboro North Carolina, 27534, United States
Wayne Memorial Hospital
Goldsboro North Carolina, 27534, United States
Onslow Memorial Hospital
Jacksonville North Carolina, 28546, United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville North Carolina, 28546, United States
Strecker Cancer Center-Belpre
Belpre Ohio, 45714, United States
Adena Regional Medical Center
Chillicothe Ohio, 45601, United States
Good Samaritan Hospital - Cincinnati
Cincinnati Ohio, 45220, United States
Bethesda North Hospital
Cincinnati Ohio, 45242, United States
TriHealth Cancer Institute-Westside
Cincinnati Ohio, 45247, United States
TriHealth Cancer Institute-Anderson
Cincinnati Ohio, 45255, United States
Ohio State University Comprehensive Cancer Center
Columbus Ohio, 43210, United States
Mount Carmel East Hospital
Columbus Ohio, 43213, United States
Columbus Oncology and Hematology Associates Inc
Columbus Ohio, 43214, United States
Riverside Methodist Hospital
Columbus Ohio, 43214, United States
Grant Medical Center
Columbus Ohio, 43215, United States
The Mark H Zangmeister Center
Columbus Ohio, 43219, United States
Mount Carmel Health Center West
Columbus Ohio, 43222, United States
Doctors Hospital
Columbus Ohio, 43228, United States
Delaware Health Center-Grady Cancer Center
Delaware Ohio, 43015, United States
Delaware Radiation Oncology
Delaware Ohio, 43015, United States
Grady Memorial Hospital
Delaware Ohio, 43015, United States
Dublin Methodist Hospital
Dublin Ohio, 43016, United States
Mount Carmel Grove City Hospital
Grove City Ohio, 43123, United States
Fairfield Medical Center
Lancaster Ohio, 43130, United States
Saint Rita's Medical Center
Lima Ohio, 45801, United States
OhioHealth Mansfield Hospital
Mansfield Ohio, 44903, United States
Marietta Memorial Hospital
Marietta Ohio, 45750, United States
OhioHealth Marion General Hospital
Marion Ohio, 43302, United States
Knox Community Hospital
Mount Vernon Ohio, 43050, United States
Licking Memorial Hospital
Newark Ohio, 43055, United States
Newark Radiation Oncology
Newark Ohio, 43055, United States
Mercy Health Perrysburg Cancer Center
Perrysburg Ohio, 43551, United States
Southern Ohio Medical Center
Portsmouth Ohio, 45662, United States
ProMedica Flower Hospital
Sylvania Ohio, 43560, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo Ohio, 43606, United States
Saint Vincent Mercy Medical Center
Toledo Ohio, 43608, United States
Mercy Health - Saint Anne Hospital
Toledo Ohio, 43623, United States
Saint Ann's Hospital
Westerville Ohio, 43081, United States
Genesis Healthcare System Cancer Care Center
Zanesville Ohio, 43701, United States
University of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States
Mercy Hospital Oklahoma City
Oklahoma City Oklahoma, 73120, United States
Saint Alphonsus Medical Center-Baker City
Baker City Oregon, 97814, United States
Saint Alphonsus Medical Center-Ontario
Ontario Oregon, 97914, United States
Saint Joseph Regional Cancer Center
Bryan Texas, 77802, United States
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork Utah, 84003, United States
Sandra L Maxwell Cancer Center
Cedar City Utah, 84720, United States
Farmington Health Center
Farmington Utah, 84025, United States
Logan Regional Hospital
Logan Utah, 84321, United States
Intermountain Medical Center
Murray Utah, 84107, United States
McKay-Dee Hospital Center
Ogden Utah, 84403, United States
Utah Valley Regional Medical Center
Provo Utah, 84604, United States
Riverton Hospital
Riverton Utah, 84065, United States
Saint George Regional Medical Center
Saint George Utah, 84770, United States
Utah Cancer Specialists-Salt Lake City
Salt Lake City Utah, 84106, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City Utah, 84112, United States
LDS Hospital
Salt Lake City Utah, 84143, United States
South Jordan Health Center
South Jordan Utah, 84009, United States
MultiCare Auburn Medical Center
Auburn Washington, 98001, United States
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton Washington, 98310, United States
Harrison Medical Center
Bremerton Washington, 98310, United States
Highline Medical Center-Main Campus
Burien Washington, 98166, United States
Saint Elizabeth Hospital
Enumclaw Washington, 98022, United States
Saint Francis Hospital
Federal Way Washington, 98003, United States
MultiCare Gig Harbor Medical Park
Gig Harbor Washington, 98335, United States
Saint Clare Hospital
Lakewood Washington, 98499, United States
Jefferson Healthcare
Port Townsend Washington, 98368, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo Washington, 98370, United States
MultiCare Good Samaritan Hospital
Puyallup Washington, 98372, United States
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Spokane Valley Washington, 99216, United States
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Spokane Washington, 99204, United States
MultiCare Deaconess Cancer and Blood Specialty Center - North
Spokane Washington, 99218, United States
Franciscan Research Center-Northwest Medical Plaza
Tacoma Washington, 98405, United States
Mary Bridge Children's Hospital and Health Center
Tacoma Washington, 98405, United States
MultiCare Tacoma General Hospital
Tacoma Washington, 98405, United States
Northwest Medical Specialties PLLC
Tacoma Washington, 98405, United States
Cancer Center of Western Wisconsin
New Richmond Wisconsin, 54017, United States
Cheyenne Regional Medical Center-West
Cheyenne Wyoming, 82001, United States
Billings Clinic-Cody
Cody Wyoming, 82414, United States
Welch Cancer Center
Sheridan Wyoming, 82801, United States

How clear is this clinincal trial information?

Study is for people with:

Melanoma

Phase:

Phase 2

Estimated Enrollment:

56

Study ID:

NCT02775851

Recruitment Status:

Active, not recruiting

Sponsor:


National Cancer Institute (NCI)

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.