Sonazoid-Enhanced Ultrasound in Detecting Sentinel Lymph Node in Patients With Cutaneous Melanoma

Inclusion Criteria:

Cutaneous melanoma with Breslow depth > 1 mm or melanoma Breslow depth of 0.76 - 1.00 mm in setting of ulceration, extensive regression
Mitotic rate >= 1/mm^2
Presence of angiolymphatic invasion
Deep positive margin
No known allergies to contrast material

Exclusion Criteria:

Pregnant or nursing
Patients with known cardiac shunt
Patients with class II heart failure or worse, per New York Heart Association (NYHA) classification
Patients who have experienced an acute coronary syndrome or angina in the past 6 months
Patients who have undergone coronary artery bypass grafting (CABG) or coronary stenting in the past 3 years
Patients with evidence of moderate or severe cardiac valvular disease on echocardiogram
Patients with evidence of moderate or severe pulmonary hypertension on echocardiogram
Patients with stage II chronic obstructive pulmonary disease (COPD) or worse, per Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification
Patients with hypersensitivity to sonazoid or one of its components
Patients with hypersensitivity to egg or egg products, because sonazoid contains a chicken egg-derived surfactant (hydrogenated egg phosphatidylserine sodium)
Patients who cannot consent for themselves