Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma

Inclusion Criteria:

Provide signed and dated informed consent form or have a Legally Authorized Representative (LAR) who can give consent
Willing to comply with all study procedures and be available for the duration of the study
Must be a candidate for radiation therapy
Karnofsky performance status (KPS) >= 60
Diagnosed with uveal melanoma either clinically or pathologically on biopsy
Uveal melanoma of one eye only
Localized uveal melanoma, with no evidence of metastasis
Women of childbearing potential must have a negative urine or serum pregnancy test within 14 days prior to enrollment

Exclusion Criteria:

Tumor thickness more than 14 mm as measured by ultrasound
Active collagen vascular disease
Any contraindication to intravitreal injections including: elevated intraocular pressure, ocular or periocular infection, active intraocular inflammation, or other determined by treating physician
Known allergic reactions to components of intravitreal Aflibercept
Patients with known hypercoagulable syndromes
Prior radiation to the eye or brain
Life expectancy less than 6 months
Blind in both eyes
Patients unable to receive contrast enhanced brain magnetic resonance imaging (MRI)
Deaf in both ears
Patients have hypersensitivity to intravitreal Aflibercept
Patients is on or within 1 month of systemic anti-VEGF treatment
Patients who are candidates for brachytherapy
Patients for whom enucleation is standard of care

Pregnancy or active breastfeeding. Sexually active men or women of childbearing potential who are unwilling to practice adequate contraception prior to the initial dose/start of the first treatment, during the study, and for at least 3 months after the last dose. Adequate contraceptive measures include stable use of oral contraceptives or other prescription pharmaceutical contraceptives for 2 or more menstrual cycles prior to screening; intrauterine device; bilateral tubal ligation; vasectomy; condom plus contraceptive sponge, foam, or jelly, or diaphragm plus contraceptive sponge, foam, or jelly

Contraception is not required for men with documented vasectomy
Postmenopausal women must be amenorrheic for at least 12 months in order not to be considered of childbearing potential. Pregnancy testing and contraception are not required for women with documented hysterectomy or tubal ligation