Melanoma Clinical Trial

Using MC1R Genotype to Impact Melanoma Risk Behavior

Summary

The purpose of this study is to examine how different messages about risk of melanoma can impact the way people protect themselves against developing these diseases.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

CRITERIA FOR: NON-HISPANIC WHITE POPULATION

Investigators will recruit participants from the Family Medicine and General Internal Medicine clinics of the Morsani Center at the University of South Florida.
White, non-Hispanic patients who self-report a low phenotypic risk profile for development of melanoma and are able to read and speak English fluently.
18 years of age or older
Capable of giving informed consent
Potential participants will be screened for eligibility based on responses to questions about skin phenotypes, early detection behaviors and past history of melanoma.
After signing informed consent, a biologic sample (saliva) will be collected for the purpose of DNA extraction determination of MC1R genotypes. All participants who carry high risk MC1R genotypes and a proportion of those who carry low risk or no MC1R variants will be randomized to the control or intervention arm.

CRITERIA FOR: HISPANIC POPULATION

Investigators will recruit participants living in Tampa Bay and Puerto Rico as part of the U54 Ponce Health Sciences University-Moffitt Cancer Center (PHSU-MCC) Partnership. In Tampa Bay, participants will be recruited from the Family Medicine and General Internal Medicine clinics of the Morsani Center at the University of South Florida, and from the Suncoast Community Health Centers.
Patients who self-report as Hispanics and are able to read and speak either Spanish or English fluently.
18 years of age or older
Capable of giving informed consent
Potential participants will be screened for eligibility based on responses to early detection behaviors and past history of melanoma.
After signing informed consent, a biologic sample (saliva) will be collected for the purpose of DNA extraction determination of MC1R genotypes. All participants who carry high risk MC1R genotypes and a proportion of those who carry low risk or no MC1R variants will be randomized to the control or intervention arm.

Exclusion Criteria:

CRITERIA FOR: NON-HISPANIC WHITE POPULATION

Have had a skin examination within the past year.
Do not meet race/ethnicity criteria for their group
White, non-Hispanic group - participants reporting sun-sensitive phenotypes
A personal history of melanoma

CRITERIA FOR: HISPANIC POPULATION

Have had a skin examination within the past year.
Do not meet ethnicity criteria for their group
White, non-Hispanic group - participants reporting sun-sensitive phenotypes
Participants with a personal history of melanoma and/or more personal history of more than on squamous cell cancer (SCC) and/or Basal Cell Cancer (BCC)

Study is for people with:

Melanoma

Estimated Enrollment:

2054

Study ID:

NCT03509467

Recruitment Status:

Completed

Sponsor:

H. Lee Moffitt Cancer Center and Research Institute

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There are 2 Locations for this study

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H. Lee Moffitt Cancer Center and Research Institute
Tampa Florida, 33612, United States
Ponce School of Medicine
Ponce , 00716, Puerto Rico

How clear is this clinincal trial information?

Study is for people with:

Melanoma

Estimated Enrollment:

2054

Study ID:

NCT03509467

Recruitment Status:

Completed

Sponsor:


H. Lee Moffitt Cancer Center and Research Institute

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