Multiple Myeloma Clinical Trial

A Diagnostic Study of CD38-Targeted ImmunoPET of Myeloma

Summary

Evaluation of myeloma disease burden is currently suboptimal. This limits treatment planning and evaluation of residual disease following treatment. 89Zr-DFO-daratumumab is a novel immunoPET tracer, designed to detect CD38 on myeloma cells and allow visualization of myeloma in a PET scanner. A phase I study of 89Zr-DFO-daratumumab demonstrated safety and successful visualization of myeloma with 89Zr-DFO-daratumumab. This will be a phase II study of 89Zr-DFO-daratumumab to evaluate potential clinical applications of this novel imaging agent.

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Full Description

This will be a phase II clinical trial to assess the potential clinical value of 89Zr-DFO-daratumumab immunoPET. 60 patients with multiple myeloma (MM) and a plan for daratumumab containing combination therapy will be enrolled. Prior to therapy, current standard of care (SoC), as well as a research 89Zr-DFO-daratumumab PET/CT, tests will be performed. Patients will then undergo standard of care therapy for myeloma as defined by a medical oncologist and SoC response assessments as defined by the International Myeloma Working Group (IMWG). Upon suspected complete response (CR) or completion of 12 cycles of therapy, a repeat research 89Zr-DFO-daratumumab PET/CT will be repeated and standard of care minimal residual disease (MRD) assessment will be performed. This design will determine how 89Zr-DFO-daratumumab immunoPET compares with current methods of measuring and localizing disease prior to therapy, if immunoPET can predict response to therapy, and how immunoPET compares with current methods of detecting MRD after therapy.

The therapy in this trial is standard of care. The research component is the addition of a novel immunoPET imaging test before and after standard of care therapy, to determine if the novel imaging test adds value over current measures of myeloma disease burden.

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Eligibility Criteria

Inclusion Criteria:

Male or female ≥ 21 years of age
Histologically/immunohistochemistry-confirmed CD38-positive multiple myeloma
At least one tumor lesion on CT, MRI, or FDG PET/CT within 90 days of protocol enrollment
ECOG performance status 0 to 2
Written informed consent obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study

Exclusion Criteria:

Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.
Life expectancy < 12 months
Patients who cannot undergo PET/CT scanning because of weight limits. PET/CT scanners may not be able to function with patients over 450 pounds.
History of anaphylactic reaction to humanized or human antibodies.

Study is for people with:

Multiple Myeloma

Phase:

Phase 2

Estimated Enrollment:

60

Study ID:

NCT04814615

Recruitment Status:

Recruiting

Sponsor:

Hoag Memorial Hospital Presbyterian

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There are 2 Locations for this study

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Hoag Memorial Hospital Presbyterian
Irvine California, 92614, United States More Info
Beth Thomsen
Contact
[email protected]
University of Miami
Miami Florida, 33136, United States More Info
Michelle D. Armogan
Contact
305-243-7479
[email protected]
C. Ola Landgren, MD, PhD.
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 2

Estimated Enrollment:

60

Study ID:

NCT04814615

Recruitment Status:

Recruiting

Sponsor:


Hoag Memorial Hospital Presbyterian

How clear is this clinincal trial information?

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