Multiple Myeloma Clinical Trial
A Study of Real-life Current Standards of Care in Patients With Relapsed and/or Refractory Multiple Myeloma Who Received at Least 3 Prior Lines of Therapy Including Proteasome Inhibitor (PI), Immunomodulatory Drug (IMID), and Cluster of Differentiation 38 (CD38) Monoclonal Antibody Treatment
Summary
The purpose of this study is to assess the safety and clinical response including overall response rate (ORR) of real-life standard-of-care (SOC) treatments under routine clinical practice, over a 24-month period, in patients with relapsed/refractory multiple myeloma (RRMM).
Eligibility Criteria
Inclusion Criteria:
Have a documented diagnosis of multiple myeloma according to International myeloma working group (IMWG) diagnostic criteria
Received at least 3 prior lines of therapy or are double refractory to a proteasome inhibitor (PI) and an immunomodulatory agent (IMID) (induction with or without hematopoietic stem cell transplant and with or without maintenance therapy is considered a single regimen). Patients will have undergone at least 1 complete cycle of treatment for each regimen (unless progressive disease was the best response)
Must have documented evidence of progressive disease based on study physician's determination of response by the IMWG response criteria on or after the last regimen. Patients with documented evidence of progressive disease within the previous 6 months and who are refractory or nonresponsive to their most recent line of treatment afterwards are also eligible
Have an Eastern Cooperative Oncology Group (ECOG) Performance Status grade of 0 or 1
Must not be pregnant or must not plan to become pregnant within the study period
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There are 74 Locations for this study
Glendale California, 91204, United States
Greenbrae California, 94904, United States
Weeki Wachee Florida, 34607, United States
Peoria Illinois, 61615, United States
Southfield Michigan, 48075, United States
Bolivar Missouri, 65613, United States
Saint Louis Missouri, 63110, United States
Las Vegas Nevada, 89102, United States
Flemington New Jersey, 08822, United States
East Hills New York, 11548, United States
East Setauket New York, 11733, United States
Columbus Ohio, 43210, United States
Charleroi , 6000, Belgium
Edegem , 2650, Belgium
Leuven , 3000, Belgium
Yvoir , 5530, Belgium
Le Mans , 72000, France
Lille Cedex , 59000, France
Montpellier , 34295, France
Nantes , 44093, France
Paris cedex 10 , 75475, France
PARIS cedex 12 , 75571, France
Pierre-Bénite , 69495, France
Poitiers , 86021, France
Toulouse cedex 9 , 31059, France
Hamburg , 20251, Germany
Heidelberg , 69120, Germany
Koeln , 50397, Germany
Muenster , 48149, Germany
Tübingen , 72076, Germany
Würzburg , 97080, Germany
Bari , 70124, Italy
Bari , 70124, Italy
Bologna , 40138, Italy
Catania , 95128, Italy
Firenze , 50134, Italy
Genova , 16132, Italy
Meldola , 47014, Italy
Padova , 35128, Italy
Palermo , 90146, Italy
Pavia , 27100, Italy
Rionero in Vulture , 85028, Italy
Roma , 00161, Italy
Roma , 00168, Italy
San Giovanni Rotondo , 71013, Italy
Tricase , 73039, Italy
Turin , 10126, Italy
Amsterdam , 1081 , Netherlands
Groningen , 9713 , Netherlands
Rotterdam , 3075 , Netherlands
Lublin , 20-08, Poland
Poznan , 60-56, Poland
Moscow , 12528, Russian Federation
Samara , 44309, Russian Federation
St-Petersburg , 19102, Russian Federation
Barcelona , 08908, Spain
Cadiz , 11009, Spain
Jerez de la Frontera , 11407, Spain
Leon , 24008, Spain
Madrid , 28034, Spain
Madrid , 28041, Spain
Palma , 7120, Spain
Pamplona , 31008, Spain
Salamanca , 37007, Spain
Santander , 39008, Spain
Terrassa , 08221, Spain
Valencia , 46017, Spain
Valladolid , 47003, Spain
Birmingham , B9 5S, United Kingdom
Bristol , BS10 , United Kingdom
Kent , ME16 , United Kingdom
London , SE5 9, United Kingdom
London , SW17 , United Kingdom
Nottingham , NG5 1, United Kingdom
Surrey , SM2 5, United Kingdom
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