Multiple Myeloma Clinical Trial

A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

Summary

The primary purpose of the phase 1 part of the study is to evaluate safety and tolerability of AMG 701 monotherapy to identify the RP2D for AMG 701 monotherapy followed by a dose-confirmation part to gather further safety data for AMG 701 monotherapy at the RP2D in adult subjects with relapsed/refractory multiple myeloma (RRMM). In addition, this study will include a sequential dose exploration part to identify the RP2D of AMG 701 in combination with pomalidomide, with and without dexamethasone (AMG 701-P+/-d). Phase 2 will consist of the dose-expansion part to gain further efficacy and safety experience with AMG 701 monotherapy in adult subjects with RRMM.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Multiple myeloma meeting the following criteria:

Pathologically-documented diagnosis of multiple myeloma that is relapsed or is refractory as defined by the following:

Relapsed after > or = 3 lines of prior therapy that must include all approved and available therapies deemed eligible by the investigator, inclusing at a minimum of a proteasome inhibitor (PI), an immunomodulatory drug (IMiD), and, where approved and available, a CD38-directed cytolytic antibody in combination in the same line or separate lines of treatment OR refractory to PI, IMiD, and CD38- directed cytolytic antibody,
Subjects who could not tolerate a PI, IMiDs, or a CD38-directed cytolytic antibody are eligible to enroll in the study.
Measurable disease as per IMWG response criteria
Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 2

Inclusion criteria specific to AMG 701-P±d include:

Subjects must have received ≥ 2 lines of prior therapy that must include a proteasome inhibitor (PI), lenalidomide, and where approved and available a CD38-directed antibody. These therapies may be in the same line or separate lines of treatment.
Subjects must have responded to at least 1 prior line with at least a PR.
Subjects that have previously received pomalidomide must not have been removed from therapy due to toxicity attributable to pomalidomide and must be at least 6 months from their last dose of pomalidomide.
Subjects must not have known intolerance to doses of dexamethasone up to 40 mg weekly (20 mg weekly if > 75 years).

Exclusion Criteria:

Known extramedullary relapse in the absence of any measurable medullary involvement
Known central nervous system involvement by multiple myeloma
Autologous stem cell transplantation less than 90 days prior to study day 1
Recent history of primary plasma cell leukemia (within last 6 months prior to enrollment) or evidence of primary or secondary plasma cell leukemia at the time of screening
Waldenstrom's macroglobulinemia
Prior amyloidosis (subjects with multiple myeloma with asymptomatic deposition of amyloid plaques found on biopsy would be eligible if all other criteria are met)
Treatment with systemic immune modulators including, but not limited to, nontopical systemic corticosteroids (unless the dose is ≤ 10 mg/day prednisone or equivalent), cyclosporine, and tacrolimus within 2 weeks before study day 1
Last anticancer treatment (chemotherapy, IMiD, PI, molecular targeted therapy) < 2 weeks prior to study day 1 or treatment with a therapeutic antibody less than 4 weeks prior to study day 1 as well as systemic radiation therapy within 28 days prior to study day 1 or focal radiotherapy within 14 days prior to study day 1.
Prior treatment with any drug or construct that targets BCMA on tumor cells (eg, other bispecific antibody constructs, antibody drug conjugates, or CAR-T cells), other than Group C where prior treatment with GSK2857916 (belantamab mafodotin) is required.

Exclusion criteria specific to AMG 701-P±d include:

History of serious hypersensitivity associated with thalidomide, pomalidomide, or lenalidomide (> grade 3).
Multiple myeloma with IgM subtype.
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes).
Contraindication to pomalidomide or dexamethasone.
Glucocorticoid therapy within 14 days prior to randomization that exceeds a cumulative dose of 160 mg of dexamethasone or equivalent dose of other corticosteroids.
Treatment with systemic immune modulators including, but not limited to, non-topical systemic corticosteroids (unless the dose is ≤ 10 mg/day prednisone or equivalent), cyclosporine, and tacrolimus within 2 weeks before study day 1 or 4 weeks before study day 1 for Phase 1 dose-confirmation.
Female subjects of childbearing potential with a positive pregnancy test assessed within 14 days prior to first dose of study drugs and/or a positive urine pregnancy test within 24 hours prior to first dose. In addition, females of childbearing potential unwilling to undergo pregnancy testing weekly during the first 4 weeks of pomalidomide use followed by pregnancy testing every 4 weeks in females with regular menses or every 2 weeks in females with irregular menstrual cycles.
Male subjects with a female partner of childbearing potential and female subjects of childbearing potential who are unwilling to use 2 methods of contraception (1 of which must be highly effective during the study and for an additional 75 days (females) and 135 days (males) after receiving the last dose of AMG 701, or 28 days after the last dose pomalidomide (males and females) or dexamethasone (females), whichever occurs later.
Females who are lactating/breastfeeding or who plan to breastfeed while on study through 75 days after receiving the last dose of AMG 701, or 28 days after the last dose pomalidomide or dexamethasone, whichever occurs later.
Females planning to become pregnant while on study through 75 days after receiving the last dose of AMG 701 or 28 days after the last dose pomalidomide or dexamethasone, whichever occurs later.
Male subjects with a pregnant partner who are unwilling to practice abstinence or use a latex or synthetic condom (even if they have had a vasectomy with medical confirmation of surgical success) during treatment (including during dose interruptions) and for an additional 135 days after the last dose of AMG 701, or 28 days after the last dose pomalidomide, whichever occurs later.
Males who are unwilling to abstain from sperm donation while on study through 135 days after receiving the last dose of AMG 701 or 28 days after the last dose pomalidomide, whichever occurs later.

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

174

Study ID:

NCT03287908

Recruitment Status:

Active, not recruiting

Sponsor:

Amgen

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There are 33 Locations for this study

See Locations Near You

Mayo Clinic - Arizona
Scottsdale Arizona, 85259, United States
University of Arkansas for Medical Sciences Myeloma Institute Slot 816
Little Rock Arkansas, 72205, United States
Mayo Clinic Florida
Jacksonville Florida, 32224, United States
Winship Cancer Institute Emory U
Atlanta Georgia, 30322, United States
University of Chicago Medical Center - Multiple Myeloma Research Consortium
Chicago Illinois, 60637, United States
Dana Farber Cancer Institute
Boston Massachusetts, 02215, United States
Mayo Clinic
Rochester Minnesota, 55905, United States
Washington University
Saint Louis Missouri, 63110, United States
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Icahn School of Medicine at Mount Sinai
Hackensack New Jersey, 07601, United States
Columbia University Medical Center
New York New York, 10032, United States
New York Presbyterian Hospital, Weill Cornell Medical College
New York New York, 10065, United States
Levine Cancer Institute
Charlotte North Carolina, 28204, United States
Wake Forest Baptist Health
Winston-Salem North Carolina, 27157, United States
University of Texas MD Anderson Cancer Center
Houston Texas, 77030, United States
University of Utah Huntsman Cancer Institute
Salt Lake City Utah, 84112, United States
The Medical College of Wisconsin
Milwaukee Wisconsin, 53226, United States
Princess Alexandra Hospital
Woolloongabba Queensland, 4102, Australia
Peter MacCallum Cancer Centre
Melbourne Victoria, 3000, Australia
The Alfred Hospital
Melbourne Victoria, 3004, Australia
University Health Network-Princess Margaret Cancer Centre
Toronto Ontario, M5G 1, Canada
McGill University Health Centre Glen Site
Montreal Quebec, H4A 3, Canada
Universitätsklinikum Heidelberg
Heidelberg , 69120, Germany
Universitätsklinikum Schleswig Holstein Campus Kiel
Kiel , 24105, Germany
Universitaetsklinikum Wuerzburg
Wuerzburg , 97080, Germany
Nagoya City University Hospital
Nagoya-shi Aichi, 467-8, Japan
Gunma University Hospital
Maebashi-shi Gunma, 371-8, Japan
Kobe City Medical Center General Hospital
Kobe-shi Hyogo, 650-0, Japan
Kanazawa University Hospital
Kanazawa-shi Ishikawa, 920-8, Japan
National Hospital Organization Okayama Medical Center
Okayama-shi Okayama, 701-1, Japan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Koto-ku Tokyo, 135-8, Japan
Universitair Medisch Centrum Groningen
Groningen , 9713 , Netherlands
Maastricht Universitair Medisch Centrum
Maastricht , 6229 , Netherlands
Universitair Medisch Centrum Utrecht
Utrecht , 3584 , Netherlands

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

174

Study ID:

NCT03287908

Recruitment Status:

Active, not recruiting

Sponsor:


Amgen

How clear is this clinincal trial information?

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