Multiple Myeloma Clinical Trial

A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)

Summary

The purpose of this study is to evaluate the safety and preliminary efficacy of CC-92480 in combination with standard treatments.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

• Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2

For participants in Cohorts A, B, C, D, E, F, H, I, J, and K the following inclusions will also apply:

Documented diagnosis of multiple myeloma (MM) and measurable disease
Documented disease progression during or after their last antimyeloma regimen
Achieved a response (minimal response [MR] or better) to at least 1 prior treatment regimen

Exclusion Criteria:

Plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) or clinically significant amyloidosis
Known central nervous system (CNS) involvement with myeloma
Received immunosuppressive medication within the last 14 days of initiating study treatment
Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment

Other protocol-defined inclusion/exclusion criteria apply

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

384

Study ID:

NCT03989414

Recruitment Status:

Recruiting

Sponsor:

Celgene

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There are 50 Locations for this study

See Locations Near You

Colorado Blood Cancer Institute
Denver Colorado, 80218, United States
H. Lee Moffitt Cancer Center and Research Institute
Tampa Florida, 33612, United States
Winship Cancer Institute of Emory University
Atlanta Georgia, 30322, United States
Winship Cancer Institute of Emory University
Atlanta Georgia, 30322, United States More Info
Craig Hofmeister, Site 108
Contact
404-778-8580
Northwestern University Feinberg School of Medicine
Chicago Illinois, 60611, United States
University of Chicago Medicine
Chicago Illinois, 60637, United States
Massachusetts General Hospital
Boston Massachusetts, 02114, United States
Massachusetts General Hospital
Boston Massachusetts, 02114, United States More Info
Noopur Raje, Site 117
Contact
617-726-0711
Dana-Farber/Mass General Brigham Cancer Care, Inc
Boston Massachusetts, 02115, United States
Dana-Farber/Mass General Brigham Cancer Care, Inc
Boston Massachusetts, 02115, United States More Info
Paul Richardson, Site 101
Contact
617-632-6624
Beth Israel Deaconess Medical Center
Boston Massachusetts, 02215, United States
Beth Israel Deaconess Medical Center
Boston Massachusetts, 02215, United States More Info
Jacalyn Rosenblatt, Site 118
Contact
617-667-9920
Barbara Ann Karmanos Cancer Center
Detroit Michigan, 48201, United States
Mayo Clinic
Rochester Minnesota, 55905, United States
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Wake Forest University Baptist Medical Center
Winston-Salem North Carolina, 27157, United States
The Ohio State University Comprehensive Cancer Center
Columbus Ohio, 43210, United States
Sarah Cannon Cancer Center
Nashville Tennessee, 37203, United States
The University of Texas - MD Anderson Cancer Center
Houston Texas, 77030, United States
Swedish Cancer Institute
Seattle Washington, 98104, United States
Local Institution - 201
Calgary Alberta, T2N 4, Canada More Info
Site 201
Contact
Tom Baker Cancer Center
Calgary Alberta, T2N 4, Canada
Local Institution - 205
Edmonton Alberta, T6G 2, Canada More Info
Site 205
Contact
University of Alberta - Faculty of Medicine and Dentistry
Edmonton Alberta, T6G 2, Canada
Local Institution - 204
Halifax Nova Scotia, B3H 1, Canada More Info
Site 204
Contact
Queen Elizabeth II Health Sciences Centre
Halifax Nova Scotia, B3H 1, Canada
Princess Margaret Cancer Centre
Toronto Ontario, M5G 2, Canada
Hopital Maisonneuve Rosemont dba CIUSSS de lEst de lIle de Montreal
Montreal Quebec, H1T 2, Canada
Local Institution - 202
Montreal Quebec, H1T 2, Canada More Info
Site 202
Contact
Fakultni Nemocnice Brno
Brno , 625 0, Czechia
Fakultni Nemocnice Ostrava
Ostrava-Poruba , 708 5, Czechia
Charles University General Hospital
Praha 2 , 128 0, Czechia
Odense University Hospital
Odense , 5000, Denmark
Vejle Hospital
Vejle , 7100, Denmark
Hopital Claude Huriez CHRU Lille
Lille cedex , 59037, France
Local Institution - 703
Lille cedex , 59037, France More Info
Site 703
Contact
Institut Paoli Calmette Hematologie
Marseille cedex , 13273, France
Local Institution - 705
Marseille cedex , 13273, France More Info
Site 705
Contact
Hotel Dieu CHU Nantes
Nantes Cedex 01 , 44093, France
Local Institution - 704
Nantes Cedex 01 , 44093, France More Info
Site 704
Contact
Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole
Toulouse Cedex 9 , 31059, France
CHRU Hopital Bretonneau
Tours cedex , 37044, France
Charite - Universitaetsmedizin Berlin Charité - Campus Benjamin Franklin
Berlin , 12203, Germany
Universitatsklinikum Freiburg Medizinische Klinik und Poliklinik
Freiburg , 79106, Germany
Universitaetsklinikum Hamburg-Eppendorf
Hamburg , 20246, Germany
Local Institution - 601
Heidelberg , 69120, Germany More Info
Site 601
Contact
Universitaetsklinikum Heidelberg
Heidelberg , 69120, Germany
Klinikum rechts der Isar der Technischen Universitaet Muenchen
Munchen , 81675, Germany
Local Institution - 602
Munchen , 81675, Germany More Info
Site 602
Contact
Local Institution - 603
Wuerzburg , 97080, Germany More Info
Site 603
Contact
Universitaets-klinikum Wuerzburg
Wuerzburg , 97080, Germany
Alexandra General Hospital of Athens
Athens , 115 2, Greece
Local Institution - 301
Athens , 115 2, Greece More Info
Site 301
Contact
ASST Spedali Civili P.O. di Brescia
Brescia , 25123, Italy
Local Institution - 404
Brescia , 25123, Italy More Info
Site 404
Contact
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan , 20133, Italy
Azienda Ospedaliera di Reggio Emilia - Arcispedale Santa Maria Nuova
Reggio Emilia , 42100, Italy
Azienda Ospedaliera Citta della Salute e della Scienza di Torino
Torino , 10126, Italy
Local Institution - 402
Torino , 10126, Italy More Info
Site 402
Contact
Hopsital Germans Trias I Pujol
Badalona , 08916, Spain
Local Institution - 504
Badalona , 08916, Spain More Info
Site 504
Contact
Local Institution - 508
Madrid , 28027, Spain More Info
Site 508
Contact
Hospital Universitario 12 de Octubre
Madrid , 28041, Spain
Local Institution - 501
Madrid , 28041, Spain More Info
Site 501
Contact
Hospital Universitario Virgen de la Victoria
Malaga , 29010, Spain
Clinica Universidad de Navarra
Pamplona , 31008, Spain
Local Institution - 505
Pamplona , 31008, Spain More Info
Site 505
Contact
Hospital Universitario de Salamanca
Salamanca , 37007, Spain
Local Institution - 502
Salamanca , 37007, Spain More Info
Site 502
Contact
Hospital Universtario Marques de Valdecilla
Santander , 39008, Spain
Hospital Universitario y Politecnico La Fe
Valencia , 46026, Spain
Local Institution - 507
Valencia , 46026, Spain More Info
Site 507
Contact

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

384

Study ID:

NCT03989414

Recruitment Status:

Recruiting

Sponsor:


Celgene

How clear is this clinincal trial information?

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