A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM) Summary The purpose of this study is to evaluate the safety and preliminary efficacy of CC-92480 in combination with standard treatment s.
View Eligibility Criteria Eligibility Criteria Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2 For participants in Cohorts A, B, C, D, E, F, H, I, J, and K the following inclusions will also apply: Documented diagnosis of multiple myeloma (MM) and measurable disease Documented disease progression during or after their last antimyeloma regimen Achieved a response (minimal response [MR] or better) to at least 1 prior treatment regimen Exclusion Criteria: Plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) or clinically significant amyloidosis Known central nervous system (CNS) involvement with myeloma Received immunosuppressive medication within the last 14 days of initiating study treatment Uncontrolled hypertension or uncontrolled diabetes within 14 days prior to enrollment Other protocol-defined inclusion/exclusion criteria apply
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There are 50 Locations for this study
Local Institution - 119 Denver Colorado, 80218, United States
Local Institution - 104 Tampa Florida, 33612, United States
Winship Cancer Institute of Emory University Atlanta Georgia, 30322, United States
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Local Institution - 112 Chicago Illinois, 60611, United States
University of Chicago Medicine Chicago Illinois, 60637, United States
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Massachusetts General Hospital Boston Massachusetts, 02114, United States
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Dana-Farber/Mass General Brigham Cancer Care, Inc Boston Massachusetts, 02115, United States
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Beth Israel Deaconess Medical Center Boston Massachusetts, 02215, United States
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Barbara Ann Karmanos Cancer Center Detroit Michigan, 48201, United States
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Local Institution - 106 Rochester Minnesota, 55905, United States
Hackensack University Medical Center Hackensack New Jersey, 07601, United States
Local Institution - 110 Winston-Salem North Carolina, 27157, United States
The Ohio State University Comprehensive Cancer Center Columbus Ohio, 43210, United States
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Local Institution - 114 Nashville Tennessee, 37203, United States
The University of Texas - MD Anderson Cancer Center Houston Texas, 77030, United States
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Swedish Cancer Institute Seattle Washington, 98104, United States
Local Institution - 201 Calgary Alberta, T2N 4, Canada
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Local Institution - 205 Edmonton Alberta, T6G 2, Canada
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Local Institution - 204 Halifax Nova Scotia, B3H 1, Canada
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Local Institution - 203 Toronto Ontario, M5G 2, Canada
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Local Institution - 202 Montreal Quebec, H1T 2, Canada
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Local Institution - 802 Brno , 625 0, Czechia
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Local Institution - 801 Ostrava-Poruba , 708 5, Czechia
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Local Institution - 803 Praha 2 , 128 0, Czechia
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Local Institution - 902 Odense , 5000, Denmark
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Local Institution - 903 Vejle , 7100, Denmark
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Local Institution - 703 Lille cedex , 59037, France
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Local Institution - 705 Marseille cedex , 13273, France
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Local Institution - 704 Nantes Cedex 01 , 44093, France
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Local Institution - 701 Toulouse Cedex 9 , 31059, France
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Local Institution - 702 Tours cedex , 37044, France
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Local Institution - 606 Berlin , 12203, Germany
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Local Institution - 604 Freiburg , 79106, Germany
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Local Institution - 605 Hamburg , 20246, Germany
Local Institution - 601 Heidelberg , 69120, Germany
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Local Institution - 602 Munchen , 81675, Germany
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Local Institution - 603 Wuerzburg , 97080, Germany
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Local Institution - 301 Athens , 115 2, Greece
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Local Institution - 404 Brescia , 25123, Italy
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Local Institution - 401 Milan , 20133, Italy
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Local Institution - 403 Reggio Emilia , 42100, Italy
Local Institution - 402 Torino , 10126, Italy
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Local Institution - 504 Badalona , 08916, Spain
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Local Institution - 508 Madrid , 28027, Spain
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Local Institution - 501 Madrid , 28041, Spain
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Local Institution - 506 Malaga , 29010, Spain
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Local Institution - 505 Pamplona , 31008, Spain
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Local Institution - 502 Salamanca , 37007, Spain
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Local Institution - 503 Santander , 39008, Spain
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Local Institution - 507 Valencia , 46026, Spain
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