A Study to Evaluate CC-92480 in Combination With Carfilzomib and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma Summary The purpose of the study is to compare CC-92480 (BMS-986348) with carfilzomib and dexamethasone (480Kd) against carfilzomib and dexamethasone (Kd) in the treatment of RRMM.
View Eligibility Criteria Eligibility Criteria Inclusion Criteria: Participant has documented diagnosis of multiple myeloma and measurable disease, defined as any of the following: Myeloma-protein (M-protein) ≥ 0.5 grams/deciliter (g/dL) by serum protein electrophoresis (sPEP), or M-protein ≥ 200 milligrams (mg)/24-hour urine collection by urine protein electrophoresis (uPEP) or, For participants without measurable disease in sPEP or uPEP: serum free light chain levels > 100 mg/liter (L) (10 mg/dL) involved light chain and an abnormal κ/λ free light chain ratio . Participant has received at least one prior line of anti-myeloma therapy. Note: One line can contain several phases (e.g., induction, [with or without] hematopoietic stem cell transplant , (with or without) consolidation, and/or [with or without] maintenance therapy ). Participant must have received prior treatment with lenalidomide and at least 2 cycles of an anti-CD38 monoclonal antibody. Participant achieved minimal response or better to at least 1 prior anti-myeloma therapy. Participant must have documented disease progression during or after their last antimyeloma regimen. Exclusion Criteria: Participant who has had prior treatment with CC-92480 or carfilzomib. Participant has previously received allogeneic stem cell transplant at any time or received autologous stem cell transplant within 12 weeks of initiating study treatment. Additional protocol-defined criteria apply.
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There are 142 Locations for this study
USA Mitchell Cancer Institute Mobile Alabama, 36604, United States
More Info
Kaiser Permanente - Irvine Irvine California, 92618, United States
More Info
Los Angeles Hematology Oncology Medical Group Los Angeles California, 90017, United States
More Info
Innovative Clinical Research Institute Whittier California, 90603, United States
More Info
Augusta University Augusta Georgia, 30912, United States
More Info
Our Lady of the Lake RMC Baton Rouge Louisiana, 70808, United States
More Info
Dana-Farber Cancer Institute Boston Massachusetts, 02215, United States
More Info
University of Massachusetts Chan Medical School Worcester Massachusetts, 01655, United States
More Info
Regional Cancer Care Associates Little Silver New Jersey, 07739, United States
More Info
Montefiore Medical Center Bronx New York, 10467, United States
More Info
Riverside Methodist Hospital Columbus Ohio, 43214, United States
More Info
Charleston Oncology, P.A. Charleston South Carolina, 29414, United States
Houston Methodist Hospital Houston Texas, 77030, United States
More Info
Baylor Scott & White Medical Center - Temple Temple Texas, 76508, United States
More Info
Northwest Medical Specialties - Gig Harbor Tacoma Washington, 98405, United States
More Info
WVU Cancer Institute Morgantown West Virginia, 26506, United States
More Info
Local Institution - 0008 Ciudad Autónoma de Buenos Aires Buenos Aires, C1426, Argentina
More Info
Local Institution - 0079 ABB Ciudad Autónoma De Buenos Aires, C1199, Argentina
More Info
Local Institution - 0182 Rosario Santa Fe, S2000, Argentina
More Info
Local Institution - 0150 Buenos Aires , 1431, Argentina
More Info
Local Institution - 0151 Córdoba , 5000, Argentina
More Info
Royal Prince Alfred Hospital Camperdown New South Wales, 2050, Australia
More Info
Local Institution - 0160 Gosford New South Wales, 2250, Australia
More Info
Local Institution - 0078 St Leonards New South Wales, 2065, Australia
More Info
St Vincent's Hospital Sydney New South Wales, 2010, Australia
More Info
Local Institution - 0041 Brisbane Queensland, 4029, Australia
Local Institution - 0024 Adelaide South Australia, 5000, Australia
More Info
Local Institution - 0229 Hobart Tasmania, 7000, Australia
Bendigo Health Care Group Bendigo Victoria, 3550, Australia
More Info
Local Institution - 0224 East Melbourne Victoria, 3002, Australia
More Info
Local Institution - 0127 Heidelberg Victoria, 3084, Australia
More Info
St Vincent's Hospital Melbourne Victoria, 3065, Australia
More Info
Local Institution - 0266 Vienna Wien, 1060, Austria
More Info
Local Institution - 0020 Linz , 4020, Austria
More Info
Local Institution - 0017 Wien , 1090, Austria
More Info
Local Institution - 0119 Wien , 1130, Austria
More Info
Local Institution - 0121 Salvador Bahia, 41253, Brazil
More Info
Local Institution - 0076 Porto Alegre Rio Grande Do Sul, 90470, Brazil
More Info
Local Institution - 0085 Sao Paulo São Paulo, 01509, Brazil
More Info
Local Institution - 0075 Rio de Janeiro , 20775, Brazil
More Info
Local Institution - 0086 Rio de Janeiro , 22250, Brazil
Local Institution - 0073 São Paulo , 04537, Brazil
More Info
Local Institution - 0183 Halifax Nova Scotia, B3H 2, Canada
More Info
Local Institution - 0184 Toronto Ontario, M5G 2, Canada
More Info
Local Institution - 0186 Montreal Quebec, H3T 1, Canada
Local Institution - 0057 Beijing City Beijing, 10004, China
More Info
Local Institution - 0061 Beijing Beijing, 10002, China
More Info
Local Institution - 0056 Beijing Beijing, 10073, China
More Info
Local Institution - 0123 Fuzhou Fujian Fujian, 35000, China
More Info
Local Institution - 0138 Guangzhou Guangdong, 51006, China
More Info
Local Institution - 0051 Zhengzhou Henan, 45000, China
More Info
Local Institution - 0066 Wuhan Hubei, 43002, China
More Info
Local Institution - 0054 Wuhan Hubei, 43003, China
More Info
Local Institution - 0071 Changsha Hunan, 41001, China
More Info
Local Institution - 0103 Changsha Hunan, 41001, China
More Info
Local Institution - 0180 Nanjing Jiangsu, 21000, China
More Info
Local Institution - 0111 Nantong Jiangsu, 22600, China
More Info
Local Institution - 0104 Suzhou Jiangsu, 21500, China
More Info
Local Institution - 0069 Wuxi Jiangsu, 21402, China
More Info
Local Institution - 0095 Nanchang Jiangxi, 33000, China
More Info
Local Institution - 0052 Changchun Jilin, 13002, China
More Info
Local Institution - 0096 Shenyang Liaoning, 11000, China
More Info
Local Institution - 0176 Shenyang Liaoning, 11000, China
More Info
Local Institution - 0060 Xi'an Shaanxi, 71012, China
More Info
Local Institution - 0072 Jinan Shandong, 25001, China
More Info
Local Institution - 0118 Shanghai Shanghai, 0, China
More Info
Local Institution - 0091 Tianjing Tianjin, 30006, China
More Info
Local Institution - 0058 Kunming Yunnan, 65010, China
More Info
Local Institution - 0050 Hangzhou Zhejiang, 31000, China
More Info
Local Institution - 0059 Taiyuan , 03003, China
More Info
Local Institution - 0153 Medellin Antioquia, 05034, Colombia
More Info
Local Institution - 0156 Valledupar Cesar, 20000, Colombia
More Info
Local Institution - 0154 Bogota Cundinamarca, 11115, Colombia
More Info
Local Institution - 0155 Cali Valle Del Cauca, 76003, Colombia
More Info
Local Institution - 0048 Copenhagen Hovedstaden, 2100, Denmark
Local Institution - 0032 Aarhus Midtjylland, 8200, Denmark
More Info
Local Institution - 0065 Roskilde Sjælland, 4000, Denmark
More Info
Local Institution - 0129 Odense Syddanmark, 5000, Denmark
More Info
Local Institution - 0125 Vejle Syddanmark, 7100, Denmark
More Info
Local Institution - 0029 Kiel Schleswig-Holstein, 24105, Germany
More Info
Local Institution - 0007 Berlin , 12203, Germany
More Info
Local Institution - 0015 Heidelberg , D-691, Germany
More Info
Local Institution - 0102 Köln , 50937, Germany
More Info
Local Institution - 0030 Leipzig , 04103, Germany
More Info
Local Institution - 0133 Nürnberg , 90419, Germany
More Info
Local Institution - 0124 Ulm , 89081, Germany
More Info
Local Institution - 0014 Wuerzburg , 97080, Germany
More Info
Local Institution - 0136 Patras Achaḯa, 26504, Greece
More Info
Local Institution - 0135 Athens AttikÃ, 11528, Greece
More Info
Local Institution - 0134 Thessaloniki ThessalonÃki, 570 1, Greece
More Info
Local Institution - 0178 Hksar , 0, Hong Kong
More Info
Local Institution - 0036 Pécs Baranya, 7624, Hungary
More Info
Local Institution - 0094 Nyiregyhaza Szabolcs-Szatmár-Bereg, 4400, Hungary
More Info
Local Institution - 0042 Budapest , 1088, Hungary
More Info
Local Institution - 0019 Budapest , 1097, Hungary
More Info
Local Institution - 0043 Debrecen , 4032, Hungary
More Info
Local Institution - 0170 New Delhi Delhi, 11008, India
More Info
Local Institution - 0167 Gurgaon Haryana, 12200, India
More Info
Local Institution - 0161 Bengaluru Karnataka, 56002, India
More Info
Local Institution - 0168 Mumbai Maharashtra, 40001, India
More Info
Local Institution - 0171 Thane Maharashtra, 40060, India
More Info
Local Institution - 0174 Chennai Tamil Nadu, 60003, India
More Info
Local Institution - 0165 Hyderabad Telangana, 50003, India
More Info
Local Institution - 0164 Hyderabad Telangana, 50008, India
More Info
Local Institution - 0230 Chandigarh , 16001, India
More Info
Local Institution - 0163 Kolkata , 70001, India
Local Institution - 0145 Meldola Emilia-Romagna, 47014, Italy
More Info
Local Institution - 0143 Milano Lombardia, 20122, Italy
More Info
Local Institution - 0142 Rozzano Milano, 20089, Italy
More Info
Local Institution - 0189 Bologna , 40138, Italy
More Info
Local Institution - 0148 Catanzaro , 88100, Italy
More Info
Local Institution - 0147 Lecce , 73100, Italy
More Info
Local Institution - 0144 Pisa , 56100, Italy
More Info
Local Institution - 0146 Udine , 33100, Italy
More Info
Local Institution - 0217 Higashiibaraki Ibaraki, 311-3, Japan
More Info
Local Institution - 0238 Seoul Seoul-teukbyeolsi [Seoul], 03080, Korea, Republic of
More Info
Local Institution - 0239 Seoul Seoul-teukbyeolsi [Seoul], 06351, Korea, Republic of
More Info
Local Institution - 0240 Seoul Seoul-teukbyeolsi [Seoul], 06591, Korea, Republic of
More Info
Local Institution - 0113 Breda Noord-Brabant, 4818 , Netherlands
More Info
Local Institution - 0194 Enschede , 7512 , Netherlands
More Info
Local Institution - 0049 Bergen Hordaland, 5021, Norway
More Info
Local Institution - 0112 Stavanger Rogaland, 4011, Norway
More Info
Local Institution - 0081 Oslo , 0450, Norway
More Info
Local Institution - 0158 Singapore Central Singapore, 11907, Singapore
More Info
Local Institution - 0159 Singapore Central Singapore, 16960, Singapore
More Info
Local Institution - 0126 Badalona Barcelona [Barcelona], 08916, Spain
More Info
Local Institution - 0092 Barcelona Barcelona [Barcelona], 08035, Spain
More Info
Local Institution - 0038 L'Hospitalet Del Llobregat Barcelona [Barcelona], 08908, Spain
More Info
Local Institution - 0108 Majadahonda Madrid, Comunidad De, 28222, Spain
More Info
Local Institution - 0192 San Cristobal de La laguna Santa Cruz De Tenerife, 38320, Spain
Local Institution - 0201 San Cristobal de La laguna Santa Cruz De Tenerife, 38320, Spain
More Info
Local Institution - 0037 Valencia Valenciana, Comunitat, 46010, Spain
More Info
Local Institution - 0107 Granada , 18012, Spain
More Info
Local Institution - 0200 Madrid , 28007, Spain
More Info
Local Institution - 0047 Madrid , 28015, Spain
More Info
Local Institution - 0105 Málaga , 29010, Spain
More Info
Local Institution - 0177 Kaohsiung Niao Sung Dist Kaohsiung, 83301, Taiwan
More Info
Local Institution - 0012 Kaohsiung , 82445, Taiwan
More Info
Local Institution - 0001 Taichung , 407, Taiwan
More Info
Local Institution - 0002 Tainan , 704, Taiwan
More Info
Local Institution - 0149 Taipei , 11217, Taiwan
Local Institution - 0162 Taipei , 11217, Taiwan
More Info
Local Institution - 0139 Plymouth Devon, Pl6 8, United Kingdom
More Info
Local Institution - 0067 Cringleford England, NR4 7, United Kingdom
More Info
Local Institution - 0039 Birmingham , B15 2, United Kingdom
More Info
Local Institution - 0196 Glasgow , G12 0, United Kingdom
More Info
Local Institution - 0080 Leeds , LS9 7, United Kingdom
More Info
Local Institution - 0130 Sheffield , S10 2, United Kingdom
More Info
Local Institution - 0040 Taunton , TA1 5, United Kingdom
More Info How clear is this clinincal trial information?