Multiple Myeloma Clinical Trial

A Study to Evaluate CC-92480 in Combination With Carfilzomib and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

Summary

The purpose of the study is to compare CC-92480 (BMS-986348) with carfilzomib and dexamethasone (480Kd) against carfilzomib and dexamethasone (Kd) in the treatment of RRMM.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Participant has documented diagnosis of multiple myeloma and measurable disease, defined as any of the following:

Myeloma-protein (M-protein) ≥ 0.5 grams/deciliter (g/dL) by serum protein electrophoresis (sPEP), or
M-protein ≥ 200 milligrams (mg)/24-hour urine collection by urine protein electrophoresis (uPEP) or,
For participants without measurable disease in sPEP or uPEP: serum free light chain levels > 100 mg/liter (L) (10 mg/dL) involved light chain and an abnormal κ/λ free light chain ratio .
Participant has received at least one prior line of anti-myeloma therapy. Note: One line can contain several phases (e.g., induction, [with or without] hematopoietic stem cell transplant, (with or without) consolidation, and/or [with or without] maintenance therapy).
Participant must have received prior treatment with lenalidomide and at least 2 cycles of an anti-CD38 monoclonal antibody.
Participant achieved minimal response or better to at least 1 prior anti-myeloma therapy.
Participant must have documented disease progression during or after their last antimyeloma regimen.

Exclusion Criteria:

Participant who has had prior treatment with CC-92480 or carfilzomib.
Participant has previously received allogeneic stem cell transplant at any time or received autologous stem cell transplant within 12 weeks of initiating study treatment.

Additional protocol-defined criteria apply.

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Estimated Enrollment:

525

Study ID:

NCT05552976

Recruitment Status:

Recruiting

Sponsor:

Bristol-Myers Squibb

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 142 Locations for this study

See Locations Near You

USA Mitchell Cancer Institute
Mobile Alabama, 36604, United States More Info
Omar Alkharabsheh, Site 0046
Contact
251-665-8000
Kaiser Permanente - Irvine
Irvine California, 92618, United States More Info
Ashraf Aziz, Site 0190
Contact
800-398-3996
Los Angeles Hematology Oncology Medical Group
Los Angeles California, 90017, United States More Info
Lasika Seneviratne, Site 0187
Contact
626-627-6666
Innovative Clinical Research Institute
Whittier California, 90603, United States More Info
Amitabha Mazumder, Site 0005
Contact
562-693-4477
Augusta University
Augusta Georgia, 30912, United States More Info
Amany Keruakous, Site 0188
Contact
706-721-2505
Our Lady of the Lake RMC
Baton Rouge Louisiana, 70808, United States More Info
Marshall Stagg, Site 0206
Contact
225-765-3344
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States More Info
Monique Hartley-Brown, Site 0204
Contact
857-299-5736
University of Massachusetts Chan Medical School
Worcester Massachusetts, 01655, United States More Info
Muthalagu Ramanathan, Site 0232
Contact
774-442-3903
Regional Cancer Care Associates
Little Silver New Jersey, 07739, United States More Info
iuliana Shapira, Site 0222
Contact
732-530-8666
Montefiore Medical Center
Bronx New York, 10467, United States More Info
Nishi Shah, Site 0199
Contact
718-920-4826
Riverside Methodist Hospital
Columbus Ohio, 43214, United States More Info
Yvonne Efebera, Site 0172
Contact
216-965-8569
Charleston Oncology, P.A.
Charleston South Carolina, 29414, United States
Houston Methodist Hospital
Houston Texas, 77030, United States More Info
Carrie Yuen, Site 0044
Contact
832-571-7244
Baylor Scott & White Medical Center - Temple
Temple Texas, 76508, United States More Info
Rex Garland, Site 0195
Contact
254-724-5918
Northwest Medical Specialties - Gig Harbor
Tacoma Washington, 98405, United States More Info
Francis Senecal, Site 0006
Contact
253-428-8700
WVU Cancer Institute
Morgantown West Virginia, 26506, United States More Info
Salah ud din Safi, Site 0243
Contact
304-598-6984
Local Institution - 0008
Ciudad Autónoma de Buenos Aires Buenos Aires, C1426, Argentina More Info
Site 0008
Contact
Local Institution - 0079
ABB Ciudad Autónoma De Buenos Aires, C1199, Argentina More Info
Site 0079
Contact
Local Institution - 0182
Rosario Santa Fe, S2000, Argentina More Info
Site 0182
Contact
Local Institution - 0150
Buenos Aires , 1431, Argentina More Info
Site 0150
Contact
Local Institution - 0151
Córdoba , 5000, Argentina More Info
Site 0151
Contact
Royal Prince Alfred Hospital
Camperdown New South Wales, 2050, Australia More Info
Phoebe Ho, Site 0077
Contact
61 2 95158031
Local Institution - 0160
Gosford New South Wales, 2250, Australia More Info
Site 0160
Contact
Local Institution - 0078
St Leonards New South Wales, 2065, Australia More Info
Site 0078
Contact
St Vincent's Hospital
Sydney New South Wales, 2010, Australia More Info
Georgia Mccaughan, Site 0026
Contact
61293555656
Local Institution - 0041
Brisbane Queensland, 4029, Australia
Local Institution - 0024
Adelaide South Australia, 5000, Australia More Info
Site 0024
Contact
Local Institution - 0229
Hobart Tasmania, 7000, Australia
Bendigo Health Care Group
Bendigo Victoria, 3550, Australia More Info
Nora Lee, Site 0131
Contact
0354542285
Local Institution - 0224
East Melbourne Victoria, 3002, Australia More Info
Site 0224
Contact
Local Institution - 0127
Heidelberg Victoria, 3084, Australia More Info
Site 0127
Contact
St Vincent's Hospital
Melbourne Victoria, 3065, Australia More Info
Hang Quach, Site 0025
Contact
61392882698
Local Institution - 0266
Vienna Wien, 1060, Austria More Info
Site 0266
Contact
Local Institution - 0020
Linz , 4020, Austria More Info
Site 0020
Contact
Local Institution - 0017
Wien , 1090, Austria More Info
Site 0017
Contact
Local Institution - 0119
Wien , 1130, Austria More Info
Site 0119
Contact
Local Institution - 0121
Salvador Bahia, 41253, Brazil More Info
Site 0121
Contact
Local Institution - 0076
Porto Alegre Rio Grande Do Sul, 90470, Brazil More Info
Site 0076
Contact
Local Institution - 0085
Sao Paulo São Paulo, 01509, Brazil More Info
Site 0085
Contact
Local Institution - 0075
Rio de Janeiro , 20775, Brazil More Info
Site 0075
Contact
Local Institution - 0086
Rio de Janeiro , 22250, Brazil
Local Institution - 0073
São Paulo , 04537, Brazil More Info
Site 0073
Contact
Local Institution - 0183
Halifax Nova Scotia, B3H 2, Canada More Info
Site 0183
Contact
Local Institution - 0184
Toronto Ontario, M5G 2, Canada More Info
Site 0184
Contact
Local Institution - 0186
Montreal Quebec, H3T 1, Canada
Local Institution - 0057
Beijing City Beijing, 10004, China More Info
Site 0057
Contact
Local Institution - 0061
Beijing Beijing, 10002, China More Info
Site 0061
Contact
Local Institution - 0056
Beijing Beijing, 10073, China More Info
Site 0056
Contact
Local Institution - 0123
Fuzhou Fujian Fujian, 35000, China More Info
Site 0123
Contact
Local Institution - 0138
Guangzhou Guangdong, 51006, China More Info
Site 0138
Contact
Local Institution - 0051
Zhengzhou Henan, 45000, China More Info
Site 0051
Contact
Local Institution - 0066
Wuhan Hubei, 43002, China More Info
Site 0066
Contact
Local Institution - 0054
Wuhan Hubei, 43003, China More Info
Site 0054
Contact
Local Institution - 0071
Changsha Hunan, 41001, China More Info
Site 0071
Contact
Local Institution - 0103
Changsha Hunan, 41001, China More Info
Site 0103
Contact
Local Institution - 0180
Nanjing Jiangsu, 21000, China More Info
Site 0180
Contact
Local Institution - 0111
Nantong Jiangsu, 22600, China More Info
Site 0111
Contact
Local Institution - 0104
Suzhou Jiangsu, 21500, China More Info
Site 0104
Contact
Local Institution - 0069
Wuxi Jiangsu, 21402, China More Info
Site 0069
Contact
Local Institution - 0095
Nanchang Jiangxi, 33000, China More Info
Site 0095
Contact
Local Institution - 0052
Changchun Jilin, 13002, China More Info
Site 0052
Contact
Local Institution - 0096
Shenyang Liaoning, 11000, China More Info
Site 0096
Contact
Local Institution - 0176
Shenyang Liaoning, 11000, China More Info
Site 0176
Contact
Local Institution - 0060
Xi'an Shaanxi, 71012, China More Info
Site 0060
Contact
Local Institution - 0072
Jinan Shandong, 25001, China More Info
Site 0072
Contact
Local Institution - 0118
Shanghai Shanghai, 0, China More Info
Site 0118
Contact
Local Institution - 0091
Tianjing Tianjin, 30006, China More Info
Site 0091
Contact
Local Institution - 0058
Kunming Yunnan, 65010, China More Info
Site 0058
Contact
Local Institution - 0050
Hangzhou Zhejiang, 31000, China More Info
Site 0050
Contact
Local Institution - 0059
Taiyuan , 03003, China More Info
Site 0059
Contact
Local Institution - 0153
Medellin Antioquia, 05034, Colombia More Info
Site 0153
Contact
Local Institution - 0156
Valledupar Cesar, 20000, Colombia More Info
Site 0156
Contact
Local Institution - 0154
Bogota Cundinamarca, 11115, Colombia More Info
Site 0154
Contact
Local Institution - 0155
Cali Valle Del Cauca, 76003, Colombia More Info
Site 0155
Contact
Local Institution - 0048
Copenhagen Hovedstaden, 2100, Denmark
Local Institution - 0032
Aarhus Midtjylland, 8200, Denmark More Info
Site 0032
Contact
Local Institution - 0065
Roskilde Sjælland, 4000, Denmark More Info
Site 0065
Contact
Local Institution - 0129
Odense Syddanmark, 5000, Denmark More Info
Site 0129
Contact
Local Institution - 0125
Vejle Syddanmark, 7100, Denmark More Info
Site 0125
Contact
Local Institution - 0029
Kiel Schleswig-Holstein, 24105, Germany More Info
Site 0029
Contact
Local Institution - 0007
Berlin , 12203, Germany More Info
Site 0007
Contact
Local Institution - 0015
Heidelberg , D-691, Germany More Info
Site 0015
Contact
Local Institution - 0102
Köln , 50937, Germany More Info
Site 0102
Contact
Local Institution - 0030
Leipzig , 04103, Germany More Info
Site 0030
Contact
Local Institution - 0133
Nürnberg , 90419, Germany More Info
Site 0133
Contact
Local Institution - 0124
Ulm , 89081, Germany More Info
Site 0124
Contact
Local Institution - 0014
Wuerzburg , 97080, Germany More Info
Site 0014
Contact
Local Institution - 0136
Patras Achaḯa, 26504, Greece More Info
Site 0136
Contact
Local Institution - 0135
Athens Attikí, 11528, Greece More Info
Site 0135
Contact
Local Institution - 0134
Thessaloniki Thessaloníki, 570 1, Greece More Info
Site 0134
Contact
Local Institution - 0178
Hksar , 0, Hong Kong More Info
Site 0178
Contact
Local Institution - 0036
Pécs Baranya, 7624, Hungary More Info
Site 0036
Contact
Local Institution - 0094
Nyiregyhaza Szabolcs-Szatmár-Bereg, 4400, Hungary More Info
Site 0094
Contact
Local Institution - 0042
Budapest , 1088, Hungary More Info
Site 0042
Contact
Local Institution - 0019
Budapest , 1097, Hungary More Info
Site 0019
Contact
Local Institution - 0043
Debrecen , 4032, Hungary More Info
Site 0043
Contact
Local Institution - 0170
New Delhi Delhi, 11008, India More Info
Site 0170
Contact
Local Institution - 0167
Gurgaon Haryana, 12200, India More Info
Site 0167
Contact
Local Institution - 0161
Bengaluru Karnataka, 56002, India More Info
Site 0161
Contact
Local Institution - 0168
Mumbai Maharashtra, 40001, India More Info
Site 0168
Contact
Local Institution - 0171
Thane Maharashtra, 40060, India More Info
Site 0171
Contact
Local Institution - 0174
Chennai Tamil Nadu, 60003, India More Info
Site 0174
Contact
Local Institution - 0165
Hyderabad Telangana, 50003, India More Info
Site 0165
Contact
Local Institution - 0164
Hyderabad Telangana, 50008, India More Info
Site 0164
Contact
Local Institution - 0230
Chandigarh , 16001, India More Info
Site 0230
Contact
Local Institution - 0163
Kolkata , 70001, India
Local Institution - 0145
Meldola Emilia-Romagna, 47014, Italy More Info
Site 0145
Contact
Local Institution - 0143
Milano Lombardia, 20122, Italy More Info
Site 0143
Contact
Local Institution - 0142
Rozzano Milano, 20089, Italy More Info
Site 0142
Contact
Local Institution - 0189
Bologna , 40138, Italy More Info
Site 0189
Contact
Local Institution - 0148
Catanzaro , 88100, Italy More Info
Site 0148
Contact
Local Institution - 0147
Lecce , 73100, Italy More Info
Site 0147
Contact
Local Institution - 0144
Pisa , 56100, Italy More Info
Site 0144
Contact
Local Institution - 0146
Udine , 33100, Italy More Info
Site 0146
Contact
Local Institution - 0217
Higashiibaraki Ibaraki, 311-3, Japan More Info
Site 0217
Contact
Local Institution - 0238
Seoul Seoul-teukbyeolsi [Seoul], 03080, Korea, Republic of More Info
Site 0238
Contact
Local Institution - 0239
Seoul Seoul-teukbyeolsi [Seoul], 06351, Korea, Republic of More Info
Site 0239
Contact
Local Institution - 0240
Seoul Seoul-teukbyeolsi [Seoul], 06591, Korea, Republic of More Info
Site 0240
Contact
Local Institution - 0113
Breda Noord-Brabant, 4818 , Netherlands More Info
Site 0113
Contact
Local Institution - 0194
Enschede , 7512 , Netherlands More Info
Site 0194
Contact
Local Institution - 0049
Bergen Hordaland, 5021, Norway More Info
Site 0049
Contact
Local Institution - 0112
Stavanger Rogaland, 4011, Norway More Info
Site 0112
Contact
Local Institution - 0081
Oslo , 0450, Norway More Info
Site 0081
Contact
Local Institution - 0158
Singapore Central Singapore, 11907, Singapore More Info
Site 0158
Contact
Local Institution - 0159
Singapore Central Singapore, 16960, Singapore More Info
Site 0159
Contact
Local Institution - 0126
Badalona Barcelona [Barcelona], 08916, Spain More Info
Site 0126
Contact
Local Institution - 0092
Barcelona Barcelona [Barcelona], 08035, Spain More Info
Site 0092
Contact
Local Institution - 0038
L'Hospitalet Del Llobregat Barcelona [Barcelona], 08908, Spain More Info
Site 0038
Contact
Local Institution - 0108
Majadahonda Madrid, Comunidad De, 28222, Spain More Info
Site 0108
Contact
Local Institution - 0192
San Cristobal de La laguna Santa Cruz De Tenerife, 38320, Spain
Local Institution - 0201
San Cristobal de La laguna Santa Cruz De Tenerife, 38320, Spain More Info
Site 0201
Contact
Local Institution - 0037
Valencia Valenciana, Comunitat, 46010, Spain More Info
Site 0037
Contact
Local Institution - 0107
Granada , 18012, Spain More Info
Site 0107
Contact
Local Institution - 0200
Madrid , 28007, Spain More Info
Site 0200
Contact
Local Institution - 0047
Madrid , 28015, Spain More Info
Site 0047
Contact
Local Institution - 0105
Málaga , 29010, Spain More Info
Site 0105
Contact
Local Institution - 0177
Kaohsiung Niao Sung Dist Kaohsiung, 83301, Taiwan More Info
Site 0177
Contact
Local Institution - 0012
Kaohsiung , 82445, Taiwan More Info
Site 0012
Contact
Local Institution - 0001
Taichung , 407, Taiwan More Info
Site 0001
Contact
Local Institution - 0002
Tainan , 704, Taiwan More Info
Site 0002
Contact
Local Institution - 0149
Taipei , 11217, Taiwan
Local Institution - 0162
Taipei , 11217, Taiwan More Info
Site 0162
Contact
Local Institution - 0139
Plymouth Devon, Pl6 8, United Kingdom More Info
Site 0139
Contact
Local Institution - 0067
Cringleford England, NR4 7, United Kingdom More Info
Site 0067
Contact
Local Institution - 0039
Birmingham , B15 2, United Kingdom More Info
Site 0039
Contact
Local Institution - 0196
Glasgow , G12 0, United Kingdom More Info
Site 0196
Contact
Local Institution - 0080
Leeds , LS9 7, United Kingdom More Info
Site 0080
Contact
Local Institution - 0130
Sheffield , S10 2, United Kingdom More Info
Site 0130
Contact
Local Institution - 0040
Taunton , TA1 5, United Kingdom More Info
Site 0040
Contact

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Estimated Enrollment:

525

Study ID:

NCT05552976

Recruitment Status:

Recruiting

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.