Multiple Myeloma Clinical Trial
Dysregulation of Glutamine Activity in the Pathogenesis of Multiple Myeloma
Summary
The utilization of glutamine by the bone marrow plasma cells in MGUS and MM will be compared between each other after infusion of 13-carbon labelled glutamine.
Full Description
PRIMARY OBJECTIVE:
I. Compare the glutamine anaplerosis activity in bone marrow clonal plasma cells (cPCs) between patients with MGUS and MM using an in vivo and an ex vivo approach.
SECONDARY OBJECTIVES:
I. Compare the tricarboxylic acid (TCA) isotopomer enrichment in the bone marrow plasma obtained from patients with MGUS and MM with the in vivo approach.
II. Determine the peripheral blood enrichment of 13C in the TCA cycle intermediates from patients with MGUS and MM with the in vivo approach.
OUTLINE: Patients are assigned to 1 of 2 groups.
GROUP I (EX-VIVO): After an overnight fast of 6 hours, patients undergo collection of blood samples.
GROUP II (IN VIVO): After an overnight fast of 6 hours, patients receive 13-carbon labeled glutamine or 13-carbon-labeled glucose intravenously (IV) over 90 minutes. Patients also undergo collection of blood and bone marrow aspirate samples.
After completion of study, patient are followed up for 4 weeks.
Eligibility Criteria
Inclusion Criteria:
At least 18 years of age
International Myeloma Working Group (IMWG) criteria for the diagnosis of either MGUS or MM
Exclusion Criteria:
Unable to provide consent
Eastern Cooperative Oncology Group (ECOG) performance status (PS) > 3
Hemoglobin < 8 g/dL
Women who are pregnant
Prior history of adverse events with conscious sedation
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There is 1 Location for this study
Rochester Minnesota, 55905, United States More Info
Principal Investigator
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