Busulfan Safety/Efficacy as Conditioning Prior to Hematopoietic Cell Transplantation (HCT)

Inclusion Criteria - Recipient:

HLA A, B, C, DRB1 8/8 or 7/8 matched related or unrelated donor. HLA-DQ mismatches are not considered ie they are allowed in addition to these.
Histologically confirmed diagnosis by pathologic review

Diagnosis of any of the following:

Acute myelogenous leukemia (AML), Acute lymphoblastic leukemia (ALL), or Non-Hodgkin's Leukemia (NHL), in first remission with high risk of relapse, refractory to primary chemotherapy, or after first relapse; acute biphenotypic or undifferentiated leukemia is also included
Myelodysplastic Syndrome (MDS), with IPSS >1
Chronic myelogenous leukemia (CML), with GleevecR-refractory or intolerant chronic phase, or beyond chronic phase by morphology or cytogenetics
Myeloproliferative disorders, including Ph-negative CML, myelofibrosis and chronic myelomonocytic leukemia (CMML)
Multiple myeloma, refractory to two or more lines of therapy.
Chronic lymphocytic leukemia (CLL), refractory to fludarabine
Hodgkin's disease, refractory to primary chemotherapy or after first relapse
Karnofsky performance status 70-100%

Organ function:

Pulmonary: Diffusing capacity of lung for carbon monoxide (DLCO) greater than 50%
Cardiac: Left ventricular ejection fraction greater than 45%
Renal: Creatinine clearance (measured or calculated) equal or greater than 50 ml/min
Hepatic: Total bilirubin less than or equal to 2 mg/dL, (Gilbert and other syndromes with increased indirect bilirubin should be allowed); serum transaminases less than two times the upper limit of normal.
Signed informed consent form in accordance with institutional policies

Exclusion Criteria - Recipient:

Pregnant or lactating women
HIV or seropositive, confirmed by nucleic acid test (NAT)
Active central nervous system (CNS) malignancy
Patients with current uncontrolled bacterial, viral or fungal infection (currently taking medication with evidence of progression of clinical symptoms or radiologic findings) are ineligible.
Unfavorable psychosocial evaluation or history of poor compliance to prescribed medical care
Current use of metronidazole or acetominophen, unless medically necessary; patients must discontinue use of these agents at least 7 days prior to the start of BusulfexR administration
Prior use of MylotargR (gemtuzumab ozogamicin)
Prior Hematopoietic Cell Transplantation (HCT)
Prior chest or abdominal irradiation with greater than 1800 cGy

Presence of any of the following comorbid conditions:

History of myocardial infarction or coronary artery disease requiring catheterization or stent placements less than six months prior to enrollment. All participants with history of myocardial infarction or coronary artery disease must have clearance by a cardiologist to be enrolled.
Congestive heart failure (even if symptomatically controlled)
Peripheral vascular disease (including intermittent claudication or history of bypass for arterial insufficiency)
Untreated thoracic or abdominal aneurysm (6 cm or more)
History of any cerebrovascular accident including transient ischemic attacks
Dementia
Connective tissue/rheumatologic disorders with active disease
Diabetes uncontrolled by medication (including insulin)
Hemiplegia/paraplegia
History of prior malignancy (excluding nonmelanoma skin or cervical carcinoma after curative resection) less than 5 years from enrollment with the following exception. Cancer treated with curative intent less than 5 years will be reviewed on a case-by-case basis by the Principal Investigator.
History of renal failure requiring renal replacement therapy (e.g., hemodialysis, peritoneal dialysis, etc.)