Multiple Myeloma Clinical Trial

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

Summary

This research trial collects and stores tissue and blood samples from patients with cancer. Collecting and storing samples of tissue and blood from patients with cancer to study in the laboratory may help scientists create new and better models to learn about cancer and to test new cancer drugs.

View Full Description

Full Description

PRIMARY OBJECTIVE:

I. To procure biologic tissues and materials to generate preclinical models of cancer.

OUTLINE:

Tumor tissue and blood samples are procured during procedures that are required for the patients' clinical management and will be stored via xenograft (transplant to another species) models or in vitro cell culture for future analysis.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patients 18 year of age or older who are being evaluated, treated or enrolled in a clinical trial for cancer at participating sites
Patients with a histologically or cytologically confirmed diagnosis of cancer

Patients without histologically or cytologically confirmed diagnosis of cancer, but for whom approval has been requested and received from the coordinating site study coordinator

Requests for coordinating site approval should only be made if the patient's existing work-up at the time of the request demonstrates a combination of two or more of the following indicating the greater likelihood of a cancerous process in the assessment of the treating physician:

Radiographic imaging (computed tomography [CT], magnetic resonance imaging [MRI], etc.)
Elevated tumor markers
Clinical symptoms
Documented risk factors, known genetic changes (mutation, deletion, fusion, etc.), and/or known familial cancer history or syndrome
If the patient will be undergoing surgical resection at a later time and will be accessible to approach for study participation at that time, resected material following cancer diagnosis confirmation is preferred
Important: Additional medical, genetic and/or demographic work-up should not be obtained solely for determination of eligibility for protocol 9846 by these criteria. Once available, final redacted pathology confirmation must be provided to the coordinating site detailing the confirmed cancer diagnosis for patients enrolled based on the above criteria
Patients with a newly diagnosed primary and/or metastatic solid tumor, lymphoma or multiple myeloma malignancy for which they have not yet received treatment

Patients with a solid tumor, lymphoma or multiple myeloma malignancy that is recurrent, newly metastasized, or progressing while on treatment indicated by:

Radiographic evidence of tumor growth, re-growth, and/or new metastases, OR
Documentation by the treating physician of clinical disease progression

Patients currently undergoing treatment (adjuvant, neoadjuvant, etc.)

Specimen collection should occur as distant in time from the most recent drug administration as possible (e.g., after completion of a treatment cycle and immediately prior to initiation of the next cycle)
Specimens should not be collected from patients between doses within a single treatment cycle
Confirmation of viable malignancy and/or < 90% tumor necrosis must be confirmed to the National Cancer Institute (NCI) coordinating site, as indicated in the final post-operative/post-procedure pathology report

Patients with ongoing partial response (PR) or stable disease (SD) are eligible

Confirmation of viable malignancy and/or < 90% tumor necrosis must be confirmed to the NCI coordinating site, as indicated in the final post-operative/post-procedure pathology report
Ability to understand and willingness to sign a written informed consent document indicating their willingness to have their tissue or biologic fluid specimens used for research as outlined in this protocol

Exclusion Criteria:

Patients with invasive fungal infections

Patients with active and/or uncontrolled infections or who are still recovering from an infection

Actively febrile patients with uncertain etiology of febrile episode
All antibiotics should be completed at least 1 week (7 days) prior to collection
No recurrence of fever or other symptoms related to infection for at least 1 week (7 days) following completion of antibiotics
Note: Use of antibiotics for pre-operative prophylaxis is not an exclusion
Patients with human immunodeficiency virus (HIV), active or chronic hepatitis (i.e., quantifiable hepatitis B virus [HBV]-deoxyribonucleic acid [DNA] and/or positive hepatitis B surface antigen [HbsAg], quantifiable hepatitis C virus [HCV]-ribonucleic acid [RNA]) or known history of HCV, HBV, or HIV; testing for HBV, HCV, HIV or other infections for eligibility will be performed only if clinically indicated

Patients with hepatitis A as indicated by anti-hepatitis A virus (HAV) IgM reactivity

Patients that are anti-HAV IgG reactive only are eligible
Specimen collections from patients with benign tumors including but not limited to desmoid tumors, carcinoma in situ, or ongoing evidence of complete disease response (CR) based on imaging

Study is for people with:

Multiple Myeloma

Estimated Enrollment:

5000

Study ID:

NCT02474160

Recruitment Status:

Recruiting

Sponsor:

National Cancer Institute (NCI)

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There are 119 Locations for this study

See Locations Near You

University of Alabama at Birmingham Cancer Center
Birmingham Alabama, 35233, United States
Mercy Hospital Fort Smith
Fort Smith Arkansas, 72903, United States More Info
Site Public Contact
Contact
800-378-9373
Jay W. Carlson
Principal Investigator
PCR Oncology
Arroyo Grande California, 93420, United States
City of Hope Comprehensive Cancer Center
Duarte California, 91010, United States
USC / Norris Comprehensive Cancer Center
Los Angeles California, 90033, United States
University of Colorado Hospital
Aurora Colorado, 80045, United States
Smilow Cancer Center/Yale-New Haven Hospital
New Haven Connecticut, 06510, United States
Yale University
New Haven Connecticut, 06520, United States
Delaware Clinical and Laboratory Physicians PA
Newark Delaware, 19713, United States
Helen F Graham Cancer Center
Newark Delaware, 19713, United States
Medical Oncology Hematology Consultants PA
Newark Delaware, 19713, United States
Christiana Care Health System-Christiana Hospital
Newark Delaware, 19718, United States
Christiana Care Health System-Wilmington Hospital
Wilmington Delaware, 19801, United States
Augusta University Medical Center
Augusta Georgia, 30912, United States More Info
Site Public Contact
Contact
706-721-2388
[email protected]
Sharad A. Ghamande
Principal Investigator
Saint Joseph Medical Center
Bloomington Illinois, 61701, United States
Illinois CancerCare-Bloomington
Bloomington Illinois, 61704, United States
Illinois CancerCare-Canton
Canton Illinois, 61520, United States
Memorial Hospital of Carbondale
Carbondale Illinois, 62902, United States
Illinois CancerCare-Carthage
Carthage Illinois, 62321, United States
Centralia Oncology Clinic
Centralia Illinois, 62801, United States
John H Stroger Jr Hospital of Cook County
Chicago Illinois, 60612, United States More Info
Site Public Contact
Contact
312-864-5204
Thomas E. Lad
Principal Investigator
Cancer Care Specialists of Illinois - Decatur
Decatur Illinois, 62526, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Decatur Memorial Hospital
Decatur Illinois, 62526, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Crossroads Cancer Center
Effingham Illinois, 62401, United States
Illinois CancerCare-Eureka
Eureka Illinois, 61530, United States
Illinois CancerCare-Galesburg
Galesburg Illinois, 61401, United States
Western Illinois Cancer Treatment Center
Galesburg Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
Kewanee Illinois, 61443, United States
Illinois CancerCare-Macomb
Macomb Illinois, 61455, United States
Good Samaritan Regional Health Center
Mount Vernon Illinois, 62864, United States More Info
Site Public Contact
Contact
618-242-4600
Jay W. Carlson
Principal Investigator
Cancer Care Center of O'Fallon
O'Fallon Illinois, 62269, United States
Illinois CancerCare-Ottawa Clinic
Ottawa Illinois, 61350, United States
Radiation Oncology of Northern Illinois
Ottawa Illinois, 61350, United States
Illinois CancerCare-Pekin
Pekin Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin Illinois, 61554, United States
Illinois CancerCare-Peoria
Peoria Illinois, 61615, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria Illinois, 61636, United States
OSF Saint Francis Medical Center
Peoria Illinois, 61637, United States
Illinois CancerCare-Peru
Peru Illinois, 61354, United States
Valley Radiation Oncology
Peru Illinois, 61354, United States
Illinois CancerCare-Princeton
Princeton Illinois, 61356, United States
Central Illinois Hematology Oncology Center
Springfield Illinois, 62702, United States
Southern Illinois University School of Medicine
Springfield Illinois, 62702, United States
Springfield Clinic
Springfield Illinois, 62702, United States
Memorial Medical Center
Springfield Illinois, 62781, United States
Cancer Center of Kansas - Chanute
Chanute Kansas, 66720, United States
Cancer Center of Kansas - Dodge City
Dodge City Kansas, 67801, United States
Cancer Center of Kansas - El Dorado
El Dorado Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott
Fort Scott Kansas, 66701, United States
Cancer Center of Kansas-Independence
Independence Kansas, 67301, United States
Cancer Center of Kansas-Kingman
Kingman Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States
Cancer Center of Kansas-Liberal
Liberal Kansas, 67905, United States
Cancer Center of Kansas-Manhattan
Manhattan Kansas, 66502, United States
Cancer Center of Kansas - Newton
Newton Kansas, 67114, United States
Cancer Center of Kansas - Parsons
Parsons Kansas, 67357, United States
Cancer Center of Kansas - Pratt
Pratt Kansas, 67124, United States
Cancer Center of Kansas - Salina
Salina Kansas, 67401, United States
Cancer Center of Kansas - Wellington
Wellington Kansas, 67152, United States
Associates In Womens Health
Wichita Kansas, 67208, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita Kansas, 67208, United States More Info
Site Public Contact
Contact
316-268-5374
[email protected]
Shaker R. Dakhil
Principal Investigator
Ascension Via Christi Hospitals Wichita
Wichita Kansas, 67214, United States More Info
Site Public Contact
Contact
800-362-0070
[email protected]
Shaker R. Dakhil
Principal Investigator
Cancer Center of Kansas - Wichita
Wichita Kansas, 67214, United States More Info
Site Public Contact
Contact
316-268-5374
[email protected]
Shaker R. Dakhil
Principal Investigator
Wesley Medical Center
Wichita Kansas, 67214, United States
Cancer Center of Kansas - Winfield
Winfield Kansas, 67156, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore Maryland, 21287, United States
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States
Saint Joseph Mercy Hospital
Ann Arbor Michigan, 48106, United States
Bronson Battle Creek
Battle Creek Michigan, 49017, United States
Mercy Health Saint Mary's
Grand Rapids Michigan, 49503, United States
Spectrum Health at Butterworth Campus
Grand Rapids Michigan, 49503, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
Borgess Medical Center
Kalamazoo Michigan, 49048, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia Michigan, 48154, United States
Mercy Health Mercy Campus
Muskegon Michigan, 49444, United States
Lakeland Hospital Niles
Niles Michigan, 49120, United States
Spectrum Health Reed City Hospital
Reed City Michigan, 49677, United States
Lakeland Medical Center Saint Joseph
Saint Joseph Michigan, 49085, United States
Marie Yeager Cancer Center
Saint Joseph Michigan, 49085, United States
Munson Medical Center
Traverse City Michigan, 49684, United States
Mayo Clinic in Rochester
Rochester Minnesota, 55905, United States
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford Mississippi, 38655, United States More Info
Site Public Contact
Contact
901-226-1366
[email protected]
Raymond U. Osarogiagbon
Principal Investigator
Central Care Cancer Center - Bolivar
Bolivar Missouri, 65613, United States
Parkland Health Center-Bonne Terre
Bonne Terre Missouri, 63628, United States
Cox Cancer Center Branson
Branson Missouri, 65616, United States
Saint Francis Medical Center
Cape Girardeau Missouri, 63703, United States
Southeast Cancer Center
Cape Girardeau Missouri, 63703, United States
Capital Region Southwest Campus
Jefferson City Missouri, 65109, United States
Freeman Health System
Joplin Missouri, 64804, United States More Info
Site Public Contact
Contact
417-347-4030
[email protected]
Jay W. Carlson
Principal Investigator
Mercy Hospital Joplin
Joplin Missouri, 64804, United States More Info
Site Public Contact
Contact
417-556-3074
[email protected]
Jay W. Carlson
Principal Investigator
Delbert Day Cancer Institute at PCRMC
Rolla Missouri, 65401, United States More Info
Site Public Contact
Contact
573-458-7504
[email protected]
Jay W. Carlson
Principal Investigator
Mercy Clinic-Rolla-Cancer and Hematology
Rolla Missouri, 65401, United States
Heartland Regional Medical Center
Saint Joseph Missouri, 64506, United States More Info
Site Public Contact
Contact
816-271-7937
[email protected]
Jay W. Carlson
Principal Investigator
Saint Louis Cancer and Breast Institute-South City
Saint Louis Missouri, 63109, United States
Washington University School of Medicine
Saint Louis Missouri, 63110, United States
Mercy Hospital South
Saint Louis Missouri, 63128, United States More Info
Site Public Contact
Contact
[email protected]
Jay W. Carlson
Principal Investigator
Missouri Baptist Medical Center
Saint Louis Missouri, 63131, United States More Info
Site Public Contact
Contact
314-996-5569
Bryan A. Faller
Principal Investigator
Mercy Hospital Saint Louis
Saint Louis Missouri, 63141, United States More Info
Site Public Contact
Contact
314-251-7066
Jay W. Carlson
Principal Investigator
Sainte Genevieve County Memorial Hospital
Sainte Genevieve Missouri, 63670, United States
Mercy Hospital Springfield
Springfield Missouri, 65804, United States More Info
Site Public Contact
Contact
417-269-4520
Jay W. Carlson
Principal Investigator
CoxHealth South Hospital
Springfield Missouri, 65807, United States More Info
Site Public Contact
Contact
417-269-4520
Jay W. Carlson
Principal Investigator
Missouri Baptist Sullivan Hospital
Sullivan Missouri, 63080, United States
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills Missouri, 63127, United States
Cancer and Blood Specialists-Henderson
Henderson Nevada, 89052, United States
Cancer and Blood Specialists-Shadow
Las Vegas Nevada, 89106, United States
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas Nevada, 89109, United States
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas Nevada, 89113, United States
Cancer Therapy and Integrative Medicine
Las Vegas Nevada, 89121, United States
Cancer and Blood Specialists-Tenaya
Las Vegas Nevada, 89128, United States
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada
Las Vegas Nevada, 89148, United States
OptumCare Cancer Care at Fort Apache
Las Vegas Nevada, 89148, United States
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas Nevada, 89149, United States
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas Nevada, 89169, United States
Montefiore Medical Center-Einstein Campus
Bronx New York, 10461, United States
Montefiore Medical Center-Weiler Hospital
Bronx New York, 10461, United States
Montefiore Medical Center - Moses Campus
Bronx New York, 10467, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York New York, 10032, United States More Info
Site Public Contact
Contact
212-305-6361
[email protected]
Matthew Ingham
Principal Investigator
UNC Lineberger Comprehensive Cancer Center
Chapel Hill North Carolina, 27599, United States
Duke University Medical Center
Durham North Carolina, 27710, United States
Mercy Hospital Oklahoma City
Oklahoma City Oklahoma, 73120, United States More Info
Site Public Contact
Contact
405-752-3402
Jay W. Carlson
Principal Investigator
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis Tennessee, 38120, United States More Info
Site Public Contact
Contact
901-226-1366
[email protected]
Raymond U. Osarogiagbon
Principal Investigator
M D Anderson Cancer Center
Houston Texas, 77030, United States
MultiCare Auburn Medical Center
Auburn Washington, 98001, United States
Virginia Mason Bainbridge Island Medical Center
Bainbridge Island Washington, 98110, United States
Virginia Mason Federal Way Medical Center
Federal Way Washington, 98002, United States
MultiCare Gig Harbor Medical Park
Gig Harbor Washington, 98335, United States
Virginia Mason Lynnwood Medical Center
Lynnwood Washington, 98036, United States
MultiCare Good Samaritan Hospital
Puyallup Washington, 98372, United States
Virginia Mason Medical Center
Seattle Washington, 98101, United States
Marshfield Clinic-Chippewa Center
Chippewa Falls Wisconsin, 54729, United States
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire Wisconsin, 54701, United States
Gundersen Lutheran Medical Center
La Crosse Wisconsin, 54601, United States
Marshfield Medical Center-Marshfield
Marshfield Wisconsin, 54449, United States
Marshfield Clinic-Minocqua Center
Minocqua Wisconsin, 54548, United States
Marshfield Medical Center-Rice Lake
Rice Lake Wisconsin, 54868, United States
Ascension Saint Michael's Hospital
Stevens Point Wisconsin, 54481, United States
Marshfield Clinic-Wausau Center
Wausau Wisconsin, 54401, United States
Marshfield Medical Center - Weston
Weston Wisconsin, 54476, United States

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Estimated Enrollment:

5000

Study ID:

NCT02474160

Recruitment Status:

Recruiting

Sponsor:


National Cancer Institute (NCI)

How clear is this clinincal trial information?

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