Multiple Myeloma Clinical Trial

Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy

Summary

The purpose of the study is to evaluate an exercise program for individuals preparing for Chimeric Antigen Receptor (CAR) T-cell immunotherapy for hematological malignancies.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Age ≥65 years
Lymphoma, leukemia, or myeloma with commercial FDA-approved CAR-T delivery planned for ≥4 weeks following enrollment
Eastern Cooperative Oncology Group (ECOG) performance status 0-2
Able to read and speak English fluently
Capable of providing informed consent

Exclusion Criteria:

Regular engagement in Resistance training (2x/week targeting all major muscle groups)
Screen failure for exercise safety based on Physical Activity Readiness Questionnaire (PAR-Q) and Patient-Reported Measurement Information System (PROMIS) screening questions
Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV).
Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT using body weight
Numeric pain rating scale of ≥ 7 out of 10
Myopathic or rheumatologic disease that impacts physical function
Cognitive, visual, or auditory limitations that preclude safe engagement in remotely-supervised resistance training sessions or independent aerobic exercise (as determined by patients' treating oncologists and specified in clinic notes outlining disease history).

Study is for people with:

Multiple Myeloma

Estimated Enrollment:

20

Study ID:

NCT05763563

Recruitment Status:

Recruiting

Sponsor:

H. Lee Moffitt Cancer Center and Research Institute

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There is 1 Location for this study

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Moffitt Cancer Center
Tampa Florida, 33612, United States More Info
Donneisha Smith
Contact
813-745-0273
[email protected]
Nathan Parker, PhD, MPH
Principal Investigator
Ciara Freeman, MD, PhD
Principal Investigator
Frederick Locke, MD
Sub-Investigator
Michael Jain, MD, PhD
Sub-Investigator
Julio Chavez, MD, MS
Sub-Investigator
Bijal Shah, MD, MS
Sub-Investigator
Omar Casteneda Pugliani, MD
Sub-Investigator
Doris Hansen, MD
Sub-Investigator
Taiga Nishihori, MD
Sub-Investigator
Melissa Alsina, MD
Sub-Investigator
Brandon Blue, MD
Sub-Investigator
Rachid Baz, MD
Sub-Investigator
Rawan Faramand, MD
Sub-Investigator
Heather Jim, PhD
Sub-Investigator
Laura Oswald, PhD
Sub-Investigator
Jongphil Kim, PhD
Sub-Investigator

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Estimated Enrollment:

20

Study ID:

NCT05763563

Recruitment Status:

Recruiting

Sponsor:


H. Lee Moffitt Cancer Center and Research Institute

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