Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy

Inclusion Criteria:

Age ≥65 years
Lymphoma, leukemia, or myeloma with commercial FDA-approved CAR-T delivery planned for ≥4 weeks following enrollment
Eastern Cooperative Oncology Group (ECOG) performance status 0-2
Able to read and speak English fluently
Capable of providing informed consent

Exclusion Criteria:

Regular engagement in Resistance training (2x/week targeting all major muscle groups)
Screen failure for exercise safety based on Physical Activity Readiness Questionnaire (PAR-Q) and Patient-Reported Measurement Information System (PROMIS) screening questions
Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV).
Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT using body weight
Numeric pain rating scale of ≥ 7 out of 10
Myopathic or rheumatologic disease that impacts physical function
Cognitive, visual, or auditory limitations that preclude safe engagement in remotely-supervised resistance training sessions or independent aerobic exercise (as determined by patients' treating oncologists and specified in clinic notes outlining disease history).