Multiple Myeloma Clinical Trial

Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators’ Expression in Allogeneic SCT Using FluBuATG

Summary

This study is examining a chemotherapy regimen and immune suppressive medications in the setting of an allogeneic stem cell transplant. A pilot clinical trial to characterize the incidence, prevalence and function of myeloid-derived suppressor cells (MDSCs) and immune checkpoint regulators (V-domain Ig Suppressor of T-cell Activation [VISTA], cytotoxic T-lymphocyte- associated protein 4 [CTLA-4], programmed death-ligand 1 [PD-L1]) during early immune recovery following an allogeneic stem cell transplant. The site will use a myeloablative regimen of fludarabine with busulfan, adopted from CALGB 100801, to define clinical endpoints, including engraftment, 100 day survival and one year survival (Objective #1). The site will characterize the incidence, prevalence and function of MDSCs and immune checkpoint regulators in patients' blood and bone marrow following transplantation (Objective #2). The site will correlate these laboratory results with clinical outcomes and the incidence of graft-versus-host disease (GVHD). As an exploratory aim, in those patients experiencing GVHD and requiring treatment, the site will define the MDSCs frequency and checkpoint regulator expression and correlate these results with the patient's response to GVHD therapy.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Age less than or equal to 75 years
The patient must be approved for transplant by the treating transplant physician. This includes completion of their pretransplant workup, as directed by standard Dartmouth-Hitchcock Medical Center (DHMC) Standard Operating Procedures (SOPs). DHMC SOP for Pretransplant Evaluation of allogeneic recipient.

The patient must have a disease, listed below, with treatment responsiveness that the treating transplant physician believes will benefit from an allogeneic stem cell transplant. The diseases include:

Acute leukemia AML (Acute Myeloid Leukemia), ALL (Acute Lymphoid Leukemia)
Chronic leukemia CML (Chronic Myeloid Leukemia), CLL (Chronic Lymphoid Leukemia)
Myelodysplasia
Myelofibrosis
Lymphoma NHL (Non-Hodgkin's Lymphoma) and Hodgkin's disease
Plasma cell disorder, including myeloma, Waldenstrom's Macroglobulinemia

Donor availability- the patient must have an identified donor

Sibling Availability of a 6 out of 6 identical donor
Unrelated donor: Availability of a 6 out of 6 unrelated donor
No human immunodeficiency virus (HIV) infection or active hepatitis B or C
Easter Cooperative Oncology Group (ECOG) performance status 0, 1, or 2
Diffusing capacity of the lungs for carbon monoxide DLCO more than or equal to 40 percent predicted
Left ventricular ejection fraction more than or equal to 35 percent
Serum bilirubin less than 2x upper limit of normal transaminases less than 3x normal at the time of transplant
No active or uncontrollable infection
In female, a negative pregnancy test if experiencing menstrual periods
No major organ dysfunction precluding transplantation
No evidence of an active malignancy that would limit the patient's survival to less than 2 years. If there is any question, the principal investigator can make a decision.

Exclusion Criteria:

Psychiatric disorder or a mental deficiency of the patient that is sufficiently severe to make compliance with the treatment unlikely, and making informed consent impossible.
Major anticipated illness or organ failure incompatible with survival from bone marrow transplant.
History of refractory systemic infection

Donor eligibility

Human leukocyte antigen (HLA) 6 out of 6 matched related or unrelated donor.
The donor must be healthy and must be willing to serve as a donor, based on standard guidelines
The donor must have no significant comorbidities that would put the donor at marked increased risk
There is no age restriction for the donor

Informed consent must be signed by donor, if sibling donor, or by third party if unrelated donor.

Donor Exclusion Criteria

The National Marrow Donor Program (NMDP) guidelines for exclusion criteria will be used. In addition, the following donors are NOT eligible:
Syngeneic donor
Pregnant or lactating donor
Human immunodeficiency virus (HIV) or active HepB or C in the donor
Donor unfit to receive Granulocyte-colony stimulating factor (GCSF) and undergo apheresis
A donor with a psychiatric disorder or mental deficiency that makes compliance with the procedure unlikely and informed consent impossible

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

20

Study ID:

NCT02916979

Recruitment Status:

Active, not recruiting

Sponsor:

Dartmouth-Hitchcock Medical Center

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There is 1 Location for this study

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Dartmouth-Hitchcock Medical Center
Lebanon New Hampshire, 03756, United States

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

20

Study ID:

NCT02916979

Recruitment Status:

Active, not recruiting

Sponsor:


Dartmouth-Hitchcock Medical Center

How clear is this clinincal trial information?

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