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[Charlotte] => https://www.survivornet.com/charlotte/
[Cleveland] => https://www.survivornet.com/cleveland/
[Columbus] => https://www.survivornet.com/columbus/
[Dallas / Ft. Worth] => https://www.survivornet.com/dallas-ftworth/
[Denver] => https://www.survivornet.com/denver/
[Detroit] => https://www.survivornet.com/detroit/
[Indianapolis] => https://www.survivornet.com/indianapolis-ovarian-cancer/
[Louisville] => https://www.survivornet.com/louisville/
[Memphis] => https://www.survivornet.com/memphis/
[Minneapolis] => https://www.survivornet.com/minneapolis/
[Nashville] => https://www.survivornet.com/nashville/
[Phoenix] => https://www.survivornet.com/phoenix/
[Portland] => https://www.survivornet.com/portland/
[Salt Lake City] => https://www.survivornet.com/salt-lake-city/
[San Antonio] => https://www.survivornet.com/san-antonio/
[San Diego] => https://www.survivornet.com/san-diego/
[San Francisco] => https://www.survivornet.com/san-francisco/
[San Jose] => https://www.survivornet.com/san-jose/
[Seattle] => https://www.survivornet.com/seattle/
) [Multiple Myeloma] => Array
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[Ann Arbor] => https://www.survivornet.com/ann-arbor-michigan-multiple-myeloma-treatment/
[Miami] => https://www.survivornet.com/miami-florida-multiple-myeloma-treatment/
[Phoenix] => https://www.survivornet.com/phoenix-arizona-multiple-myeloma-treatment/
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[Midwest] => https://www.survivornet.com/midwest/
[Mountain States] => https://www.survivornet.com/glioma-mountain-states/
[Southeast] => https://www.survivornet.com/southeast/
) )
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Summary This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapse d or refractory multiple myeloma (RRMM).
View Full Description Full Description This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapsed or refractory multiple myeloma (RRMM). Approximately 200 patients randomized in stage 1 to one of three iberdomide dose levels of 1, 1.3, or 1.6 mg in combination with daratumumab and dexamethasone (Treatment Arms A1, A2, or A3), or to the DVd comparator arm (Treatment Arm B). In Stage 2 of the study, approximately 664 additional subjects will be randomized 1:1 between 2 treatment arms: Approximately 332 subjects will be randomized to receive Treatment Arm A (IberDd) Approximately 332 subjects will be randomized to receive Treatment Arm B (DVd) Participants in both treatment arms will continue to receive treatment until confirmed progressive disease (PD), unacceptable toxicity or withdrawal of consent. To ensure accuracy and completeness of the primary endpoint assessment of progression-free survival (PFS), participants who permanently discontinue study treatment for any reason, other than confirmed PD or withdrawal of consent, will continue to be followed for disease assessment. The study will be conducted in compliance with International Council for Harmonisation (ICH) and Good Clinical Practices (GCPs).
View Eligibility Criteria Eligibility Criteria Inclusion Criteria Documented diagnosis of multiple myeloma (MM) and measurable disease. Received 1 to 2 prior lines of anti-myeloma therapy. Must have documented disease progression during or after their last anti-myeloma regimen. Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2. Exclusion Criteria Any condition that confounds the ability to interpret data from the study. Has plasma cell leukemia, Waldenstrom's macroglobulinemia or POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes), or clinically significant amyloidosis. Known central nervous system involvement with MM. Prior therapy with iberdomide. Other protocol-defined Inclusion/Exclusion criteria apply.
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There are 251 Locations for this study
Genesis cancer and Blood Institute (GCBI) - Sarah Cannon Hot Springs Arkansas, 71913, United States
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Local Institution - 683 Corona California, 92879, United States
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Compassionate Cancer Care Medical Group Inc. Fountain Valley California, 92708, United States
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USC Norris Comprehensive Cancer Center Los Angeles California, 90033, United States
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Local Institution - 684 Newport California, 92663, United States
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Yale University School Of Medicine New Haven Connecticut, 06511, United States
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Local Institution - 029 Fort Myers Florida, 33901, United States
Baptist MD Anderson Cancer Center Jacksonville Florida, 32207, United States
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Local Institution - 028 Saint Petersburg Florida, 33705, United States
BRCR Global Tamarac Florida, 33321, United States
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Local Institution - 034 West Palm Beach Florida, 33401, United States
Emory University School of Medicine Atlanta Georgia, 30322, United States
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Local Institution - 040 Louisville Kentucky, 40207, United States
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Christus St Francis Cabrini Hospital Alexandria Louisiana, 71301, United States
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Local Institution - 682 Baton Rouge Louisiana, 70808, United States
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Local Institution - 027 Baton Rouge Louisiana, 70809, United States
Center For Cancer And Blood Disorders Bethesda Maryland, 20817, United States
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Local Institution - 010 Boston Massachusetts, 02215, United States
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University of Massachusetts Memorial Medical Center Worcester Massachusetts, 01655, United States
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HCA Midwest Health Kansas City Missouri, 64132, United States
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St. Vincent Frontier Cancer Center Billings Montana, 59102, United States
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Local Institution - 015 Summit New Jersey, 07901, United States
Local Institution - 042 Bay Shore New York, 11706, United States
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Duke University Hospital Durham North Carolina, 27705, United States
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TriHealth, Good Samaritan Hospital Cincinnati Ohio, 45220, United States
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MetroHealth Medical Center - Main Campus Cleveland Ohio, 44109, United States
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Cleveland Clinic - Taussig Cancer Institute Cleveland Ohio, 44195, United States
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Ohio Health Corporation Columbus Ohio, 43214, United States
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Oklahoma Cancer Specialists and Research Institute Tulsa Oklahoma, 74146, United States
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Oregon Health and Science University Portland Oregon, 97239, United States
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Penn State Hershey Cancer Institute Hershey Pennsylvania, 17033, United States
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Tennessee Oncology Chattanooga Tennessee, 37404, United States
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Sarah Cannon Research Institute (SCRI) Nashville Tennessee, 37203, United States
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University Of Wisconsin Madison Wisconsin, 53705, United States
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Local Institution - 080 Ciudad Autanoma De Buenos Aires Buenos Aires, C1199, Argentina
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Local Institution - 083 Villa Elisa Buenos Aires, B1894, Argentina
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Sunshine Coast University Hospital Birtinya Queensland, 4575, Australia
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The Townsville Hospital Douglas Queensland, 4814, Australia
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Royal Adelaide Hospital Adelaide South Australia, 5000, Australia
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Flinders Medical Centre, Dept Of Oncology Bedford Park South Australia, 5042, Australia
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Monash Medical Centre Clayton Victoria, 3168, Australia
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Epworth Hospital East Melbourne Victoria, 3001, Australia
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The Alfred Hospital Melbourne Victoria, 3004, Australia
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Fiona Stanley Hospital Murdoch Western Australia, 6150, Australia
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Perth Blood Institute West Perth Western Australia, 6005, Australia
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Royal Prince Alfred Hospital Camperdown , 2050, Australia
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St Vincent's Hospital Melbourne Fitzroy , 3065, Australia
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The Canberra Hospital Garran , ACT 2, Australia
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Medical University of Graz Graz , 73013, Austria
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Krankenhaus Der Barmherzigen Schwestern Linz Linz , 4010, Austria
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Universitatsklinik der PMU Salzburg , 5020, Austria
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University Hospital St. Poelten St Polten , 3100, Austria
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Medizinische Universität Wien Vienna , 1090, Austria
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Local Institution - 151 Wien , 1160, Austria
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Local Institution - 157 Wien , A-113, Austria
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AZ Sint-Jan AV Brugge Brugge , 8000, Belgium
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Cliniques Universitaires Saint-Luc Bruxelles , 1200, Belgium
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Local Institution - 056 Curitiba Parana, 80530, Brazil
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Local Institution - 058 Porto Alegre RIO Grande DO SUL, 90610, Brazil
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Local Institution - 050 Porto Alegre RS, 90460, Brazil
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Local Institution - 054 Jau SAO Paulo, 17210, Brazil
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Local Institution - 051 Barretos São Paulo, 14784, Brazil
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Local Institution - 053 Rio de Janeiro , 22793, Brazil
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Local Institution - 055 Sao Paulo , 01246, Brazil
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Fundacao Antonio Prudente - AC Camargo Cancer Center Sao Paulo , 01509, Brazil
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Clinica Sao Germano Sao Paulo , 04537, Brazil
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Local Institution - 111 Calgary Alberta, T2N 4, Canada
Local Institution - 103 Edmonton Alberta, T6G 1, Canada
BC Cancer Agency, Fraser Valley Center Surrey British Columbia, V3V 1, Canada
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Local Institution - 104 Saint John New Brunswick, E2L 3, Canada
Memorial University of NewfoundlandDr. H Bliss Murphy Cancer Center St John's Newfoundland and Labrador, A1B3V, Canada
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Queen Elizabeth Ii Health Sciences Centre Halifax Nova Scotia, B3H 1, Canada
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Local Institution - 109 Ottawa Quebec, K1H 8, Canada
Local Institution - 107 Saskatoon Saskatchewan, S7N-0, Canada
CHU de Quebec-Universite Laval Quebec , G1J 1, Canada
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The Third Xiangya Hospital of Central South University Changsha Hunan, 41001, China
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The First Affiliated Hospital of Nanchang University Nanchang Jiangxi, 33000, China
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Local Institution - 143 Xian Shaanxi, 71000, China
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Shanghai Fourth People's hospital Shanghai Shanghai, 20043, China
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Shanxi Bethune Hospital Taiyuan Shanxi, 03003, China
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The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang, 32500, China
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Beijing Boren Hospital Beijing , 10007, China
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Peking University Third Hospital Beijing , 10019, China
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Beijing Peking Union Medical College Hospital Beijing , 10073, China
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First Hospital of Jilin University Changchun , 13002, China
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Beijing Chaoyang Hospital Capital Medical University Chaoyang District , 10002, China
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Guangdong General Hospital Guangzhou , 51003, China
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Sun Yat-sen University Cancer Center Guangzhou , 51006, China
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The First Affiliated Hospital of Medical School of Zhejiang University Hangzhou City , 31000, China
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The First Affiliated Hospital of Medical School of Zhejiang University Hangzhou, Zhejiang , 31000, China
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The First Affiliated Hospital Of Harbin Medical University Harbin , 15008, China
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Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing , 21002, China
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Ruijin Hospital Shanghai Jiaotong University Shanghai , 20002, China
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Zhongshan Hospital Fudan University Shanghai , 20003, China
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Shengjing Hospital Of China Medical University Shenyang , 11000, China
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The First Affiliated Hospital Of Soochow University Suzhu , 21500, China
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Institution of Hematology & Hospital of Blood Disease, Chinese Academy of Medical Sciences Tianjin , 30002, China
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Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology Wuhan , 43003, China
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Xijing Hospital Xian , 71000, China
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Henan Cancer Hospital Zhengzhou , 0, China
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Fakultni nemocnice Brno Brno , 625 0, Czechia
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Fakultni nemocnice Ostrava Ostrava-Poruba , 708 5, Czechia
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Vseobecna Fakultni Nemocnice V Praze Prague 2 , 128 0, Czechia
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Aalborg Universitetshospital Aalborg , 9000, Denmark
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Odense University Hospital Odense , 5000, Denmark
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Sealand University Hospital Roskilde , 4000, Denmark
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Helsinki University Central Hospital Helsinki , 290, Finland
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Oulu University Hospital Oulu , 90220, Finland
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Turku University Hospital Turku , FI-20, Finland
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CH Argenteuil Victor Dupouy Argenteuil , 95100, France
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Centre Hospitalier Departemental de Vendee La Roche -Sur-Yon - Cedex 9 , 85925, France
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CHRU de Lille France Lille Cedex , 59037, France
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CHU de Nancy - Hopital Brabois- Service d'Hematologie et DE medecine Interne, 7eme etage Nancy Cedex , 54511, France
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Local Institution - 454 Nantes , 44093, France
Hopital Saint-Louis Paris Cedex , 75475, France
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Hopital Saint Antoine Paris , 75012, France
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Chu Bordeaux Pessac , 33604, France
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Centre Henri Becquerel Rouen , 76038, France
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Institut Universitaire du Cancer de Toulouse - Oncopole Toulouse Cedex 9 , 31059, France
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Uniklinik Schleswig-Holstein Kiel Kiel Schleswig-Holstein, 24105, Germany
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Klinikum der Johann Wolfgang Goethe Universitat Frankfurt am Main , 60590, Germany
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Universitaetsklinik Hamburg - Eppendorf Hamburg , 20246, Germany
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Asklepios Altona Hamburg , 22763, Germany
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Universitaetsklinikum Heidelberg Heidelberg , 69120, Germany
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Universitatsklinikum Schleswig-Holstein Lubeck , 23562, Germany
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University General Hospital of Patras Patras Achaea, 26054, Greece
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Olympion Clinic Patra Achaia, 264 4, Greece
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Alexandra General Hospital Of Athens Athens , 115 2, Greece
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Theagenio Anticancer Hospital of Thessaloniki Thessaloniki , 54007, Greece
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Georgios Papanikolaou General Hospital of Thessaloniki Thessaloniki , 57010, Greece
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Yashoda Hospitals Hitec City Hyderabad Andhra Pradesh, 50008, India
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M. S. Ramaiah Medical College And Hospital Bangalore Karnataka, 56005, India
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Local Institution - 934 Ernakulam Kerala, 68204, India
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Mumbai Oncocare Centre Vile Parle Mumbai Maharashtra, 40003, India
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Nil Ratan Sircar Medical College and Hospital Kolkata West Bengal, 70001, India
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Jawaharlal Institute of Postgraduate Medical Education & Research Pondicherry , 60500, India
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Cork University Hospital Cork , T12 D, Ireland
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Beaumont Hospital Dublin 9 , D09 V, Ireland
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University Hospital Galway Galway , H91 Y, Ireland
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Local Institution - 874 Afula HaZafon, 18101, Israel
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Rambam Medical Center Haifa , 35254, Israel
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Hadassah Medical Center Jerusalem , 91120, Israel
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Tel Aviv Sourasky Medical Center Tel Aviv , 64239, Israel
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Sheba Medical Center - PPDS Tel Hashomer , 52621, Israel
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Local Institution - 415 Roma Lazio, 00193, Italy
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A.O.U. di Bologna Policlinico S.Orsola-Malpighi Bologna , 40138, Italy
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Università di Catania- Presidio Ospedaliero Ferrarotto Catania , 95124, Italy
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A.O.U. San Martino Genova , 16132, Italy
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Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Milano , 20122, Italy
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Local Institution - 407 Milano , 20162, Italy
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A.O.U. Maggiore della Carit Novara , 28100, Italy
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Fondazione Irccs Policlinico San Matteo Pavia , 27100, Italy
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Azienda Ospedaliera Universitaria Pisana Pisa , 56126, Italy
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Local Institution - 405 Reggio Calabria , 89100, Italy
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Local Institution - 413 Reggio Emilia , 42123, Italy
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Azienda Ospedaliera S. Andrea - Università La Sapienza Roma , 00189, Italy
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IRCCS Ospedale Casa Sollievo della Sofferenza San Giovanni Rotondo FG , 71013, Italy
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Local Institution - 409 Terni , 05100, Italy
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Azienda Ospedaliero-Universitaria Santa Maria della Misericordia die Udine Udine , 33100, Italy
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Matsuyama Red Cross Hospital Matsuyama Ehime, 790-8, Japan
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Local Institution - 917 Higashi-Ibaraki-gun Ibaraki, 311-3, Japan
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Local Institution - 919 Shimotsuga Tochigi, 321-0, Japan
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Local Institution - 920 Nerima-ku Tokyo, 179-0, Japan
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Local Institution - 918 Shinagawa-ku Tokyo, 142-8, Japan
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University of Yamanashi Hospital Chuo-shi Yamanashi, 40938, Japan
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Aomori Prefectural Central Hospital Aomori , 030-8, Japan
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Chiba Cancer Center Chiba , 260-8, Japan
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National Hospital Organization Kyushu Medical Center Fukuoka , 810-8, Japan
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Kameda General Hospital Kamogawa , 296-8, Japan
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University Hospital,Kyoto Prefectural University of Medicine Kyoto-City , 602-8, Japan
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Aichi Cancer Center Nagoya , 464-8, Japan
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Nagoya City University Hospital Nagoya , 467-8, Japan
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Okayama Medical Center Okayama , 701-1, Japan
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Kindai University Hospital- Osakasayama Campus Osaka-Sayama , 589-8, Japan
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Osaka Metropolitan university Hospital Osaka , 545-8, Japan
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Sapporo Hokuyu Hospital Sapporo , 003-0, Japan
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Tohoku University Hospital Sendai , 980-8, Japan
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Japan Red Cross Medical Center Shibuya-ku , 150-8, Japan
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NTT Medical Center Tokyo Shinagawa-ku, Tokyo , 141-8, Japan
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Toyohashi Municipal Hospital Toyohashi , 441-8, Japan
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Kyungpook National University Hospital Daegu , 700-7, Korea, Republic of
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National Cancer Center Gyeonggi-do , 410-7, Korea, Republic of
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Hwasun Chonnam National University Hospital Hwasun-gun , 519-8, Korea, Republic of
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Samsung Medical Center Seoul , 06351, Korea, Republic of
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The Catholic University of Korea Seoul - Saint Mary's Hospital Seoul , 06591, Korea, Republic of
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Severance Hospital, Yonsei University Health System Seoul , 120-7, Korea, Republic of
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Seoul National University Hospital Seoul , 3080, Korea, Republic of
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Asan Medical Center Seoul , 5505, Korea, Republic of
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Local Institution - 182 Mexico City Distrito Federal, 06720, Mexico
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Local Institution - 183 Guadalajara Jalisco, 44600, Mexico
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Local Institution - 181 La Raza , 02990, Mexico
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Local Institution - 180 Mexico City , 14080, Mexico
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Albert Schweitzer Ziekenhuis Dordrecht Zuid-Holland, 3318 , Netherlands
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Vrije Universiteit Medisch Centrum (Vumc) Amsterdam , 1081 , Netherlands
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Hagaziekenhuis Den Haag , 2545 , Netherlands
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Haukeland University Hospital Bergen , N-505, Norway
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Oslo Myeloma Center - PPDS Oslo , 0450, Norway
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St. Olav's University Hospital Trondheim , 7030, Norway
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Uniwersytecki Szpital Kliniczny w Białymstoku Bialystok Podlaskie, 15-27, Poland
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Szpital Uniwersytecki W Krakowie Krakow , 30-68, Poland
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Szpital Specjalistyczny im. Jedrzeja Sniadeckiego w Nowym Saczu Nowy Sacz , 33-30, Poland
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Szpital Kliniczny im. H.Swiecickiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu Poznan , 60-56, Poland
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Specjalistyczny Szpital im. dra Alfreda Sokolowskiego Walbrzych , 58-30, Poland
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Centrum Onkologii-Instytut im.Marii Sklodowskiej-Curie Warszawa , 02-78, Poland
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Centro Hospital e Universitario de Coimbra Coimbra , 4200-, Portugal
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Instituto Portugues de Oncologia de Lisboa, Francisco Gentil Lisboa , 1099-, Portugal
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Champalimaud Cancer Center Lisboa , 1400-, Portugal
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Ipo Instituto Portugues De Oncologia Porto Porto , 4200-, Portugal
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Centro Hospitalar de Sao Joao, EPE Porto , 4200-, Portugal
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Clinica Universidad de Navarra Pamplona Navarra, 31008, Spain
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Hospital de la Santa Creu i Sant Pau Barcelona , 08025, Spain
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Hospital Universitario Vall D hebron - PPDS Barcelona , 08035, Spain
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Hospital Universitari Germans Trias I Pujol Barcelona , 08916, Spain
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Hospital San Pedro de Alcántara Caceres , 10005, Spain
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Hospital Universitario Reina Sofia Cordoba , 14001, Spain
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Hospital De La Princesa Madrid , 28006, Spain
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Clinica Universidad de Navarra-Madrid Madrid , 28027, Spain
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Hospital Universitario Ramón y Cajal Madrid , 28034, Spain
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Hospital Universitario Fundacion Jimenez Diaz Madrid , 28040, Spain
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Hospital Universitario Virgen De La Victoria Malaga , 29010, Spain
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Hospital Universitario Virgen de La Arrixaca Murcia , 30120, Spain
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Hospital Universitario Central de Asturias Oviedo , 33011, Spain
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Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca Salamanca , 37007, Spain
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Hospital Clinico Universitario De Santiago Santiago de Compostela , 15706, Spain
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Hospital Universitari i Politecnic La Fe de Valencia Valencia , 46026, Spain
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Hospital Universitario Miguel Servet Zaragoza , 50009, Spain
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Sodra Alvsborgs Sjukhus Boras Boras , 50182, Sweden
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Helsingborgs Lasarett Helsingborg , 25437, Sweden
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Kantonsspital Graubunden Chur , 7000, Switzerland
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Kantonsspital St. GallenBereich OnkologieHamatologie St. Gallen , CH-90, Switzerland
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Chang Gung Medical Foundation, Kaohsiung Memorial Hospital Niao-Sung Hsiang Kaohsiung County , 83301, Taiwan
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China Medical University Hospital Taichung City , 40447, Taiwan
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Taichung Veterans General Hospital Taichung , 40705, Taiwan
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National Cheng Kung University Hospital Tainan, Taiana , 704, Taiwan
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National Taiwan University Hospital Taipei, Zhongzheng Dist. , 10002, Taiwan
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Taipei Veterans General Hospital Taipei , 11217, Taiwan
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Chang Gung Medical Foundation, Linkou Memorial Hospital Taoyuan City , 33305, Taiwan
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Liv Hospital Ankara Kavaklıdere Ankara, 06680, Turkey
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Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi Yenimahalle Ankara, 6200, Turkey
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Marmara University Pendik Training and Research Hospital Pendik Istanbul, 34899, Turkey
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Dokuz Eylul University Medical Faculty Balçova Izmir, 35340, Turkey
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Ege University Medical Faculty Bornova Izmir, 35100, Turkey
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Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi Samsun Kurupelit, 55239, Turkey
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Ankara University Medical Faculty Ankara , 06100, Turkey
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Gazi University Faculty Of Medicine Gaziantep , 27310, Turkey
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Erciyes University Medical Faculty Kayseri , 38140, Turkey
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Local Institution - 702 Nottingham Nottinghamshire, NG5 1, United Kingdom
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Belfast City Hospital Belfast Northern Ireland , BT9 7, United Kingdom
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University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital Birmingham , B15 2, United Kingdom
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Kent and Canterbury Hospital Canterbury Kent , CT1 3, United Kingdom
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Local Institution - 704 Lancashire Blackpool , FY3 8, United Kingdom
University College London Hospitals NHS Foundation Trust - University College Hospital London , NW1 2, United Kingdom
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Guy's and St Thomas' Hospital - London London , SE1 9, United Kingdom
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Oxford University Hospitals NHS Foundation Trust-Churchill Hospital-Cancer and Haematology Centre Oxford , OX3 7, United Kingdom
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Local Institution - 711 Portsmouth , PO6 3, United Kingdom
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The Royal Marsden NHS Foundation Trust Sutton , SM2 5, United Kingdom
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New Cross Hospital Wolverhampton , WV10 , United Kingdom
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