Multiple Myeloma Clinical Trial
Panobinostat in Combination With Daratumumab, Bortezomib and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma
This phase I trial studies the possible benefits and side effects of adding panobinostat to a combination of daratumumab, bortezomib and dexamethasone in treating patients with multiple myeloma that has come back (relapsed) or has not responded to treatment (refractory). Panobinostat may stop or slow multiple myeloma by blocking the growth of new blood vessels necessary for cancer growth. Giving panobinostat in combination with daratumumab, bortezomib and dexamethasone may work better in treating relapsed/refractory multiple myeloma.
I. To evaluate the safety and tolerability of Farydak (panobinostat lactate)/Darzalex Faspro (daratumumab and hyaluronidase-fihj)/Velcade (bortezomib)/dexamethasone (FDVd) in patients with relapsed/refractory multiple myeloma (RRMM) who have previously received one line of therapy including lenalidomide or cyclophosphamide, bortezomib (V) or other proteasome inhibitor (PI), with or without autologous stem cell transplant (ASCT).
I. To evaluate the overall response rate (ORR) (per International Myeloma Working Group [IMWG] criteria) of FDVd.
II. Determine the time to response (TTR). III. Determine the duration of response (DOR). IV. Determine the progression-free survival (PFS) at 1 year. V. Determine the overall survival (OS) at 1 year.
I. Baseline and end of-study plasma cell expression of CD38. II. Changes in lymphocyte subsets with therapy. III. Baseline and end-of study analysis of total number and ratio of regulatory T cells (Tregs) with CD38+ expression.
IV. Check minimal residual disease (MRD) negativity rates by next generation sequencing in patients who attain and maintain very good partial response (VGPR) or better for at least three months.
OUTLINE: This is a dose-escalation study of panobinostat.
Patients receive panobinostat orally (PO) once daily (QD) on days 1, 3, 5, 15, 17, 19, daratumumab and hyaluronidase-fihj subcutaneously (SC) on days 1, 8, 15, 22 of cycles 1-2, days 1 and 15 of cycles 3-6, and day 1 of subsequent cycles, bortezomib SC on days 1, 8, 15, 22 and dexamethasone PO (intravenously [IV] on days of daratumumab and hyaluronidase-fihj administration) QD on days 1, 8, 15, 22. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up on days 30 and 60.
Patients 18-75 years of age with evidence of relapsed or refractory disease as defined by IMWG criteria and measurable disease as defined by any of the following:
Serum M-protein >= 0.5 g/dl (>= 10 g/l)
Urine monoclonal protein >= 200 mg/24h
Involved free light chain (FLC) level >= 10mg/dl (>= 100mg/l) and an abnormal serum free light chain ratio (< 0.26, or > 1.65)
Patients must have had at least 1 prior line of therapy including lenalidomide or cyclophosphamide, V or other PI, with or without ASCT
Patients with progressive disease (PD) as best response on V are excluded
Patients with PD on D-based therapy may be eligible at the discretion of the treating physician
Refractory (progressed on or within 120 days of treatment) to their last treatment
Patients must be off last treatment for at least 2 weeks by the beginning of treatment on this protocol
Hemoglobin >= 7g/dL
Absolute neutrophil count (ANC) >= 1000/uL
Platelets >= 70,000/uL
If plasma cell percentage on bone marrow biopsy aspirate or core is > 30%, platelet requirement will be adjusted to 50,000/ul
Total bilirubin < 1.5 mg/dL
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT)/alkaline phosphatase < 2 x the upper limit of normal (ULN)
Serum creatinine < 2mg/dL or calculated creatinine clearance of >= 30ml/min using Modification of Diet in Renal Disease Study (MDRD) formula
Left ventricular ejection fraction >= 30%; baseline echocardiogram (ECHO) is not required
No uncontrolled arrhythmias
No New York Heart Association class III-IV heart failure
12-lead electrocardiogram (ECG) with QT interval calculated by Fridericia Formula (QTcF) interval of =< 450 msec
Patient must be able to swallow capsule or tablet
Patients must provide informed consent
Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of < 2
Women of child bearing potential (WOCBP) must commit to either abstain continuously from heterosexual sexual intercourse or to use 2 methods of reliable birth control simultaneously. This includes one highly effective form of contraception (tubal ligation, intrauterine device [IUD], hormonal [birth control pills, injections, hormonal patches, vaginal rings or implants] or partner's vasectomy) and one additional effective contraceptive method (male latex or synthetic condom, diaphragm, or cervical cap). Contraception must begin 4 weeks prior to dosing and continue to 6 months after study treatment ending. Reliable contraception is indicated even where there has been a history of infertility, unless due to hysterectomy
Investigators shall counsel WOCBP and male participants who are sexually active with WOCBP on the importance of pregnancy prevention and the implications of an unexpected pregnancy
A negative pregnancy test will be required for all WOCBP within 24 hours before starting treatment drugs
Breast feeding is not permitted
Male patients must agree to use an adequate method of contraception (latex or synthetic condom) for the duration of the study and up to 6 months after study treatment ending
Criteria also applies to azoospermic males
Males should refrain from sperm donation during this time and continue for 6 months after study treatment ending
Patients with active (untreated or relapsed) central nervous system (CNS) metastasis of myeloma
Patients with Waldenstrom macroglobulinemia, primary amyloid light-chain (AL) amyloidosis, primary plasma cell leukemia, or polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome
Patients with secondary plasma cell leukemia are permitted
Patients with peripheral neuropathy > National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) grade 2
Patients receiving concurrent corticosteroids at the time protocol therapy is initiated other than for physiologic maintenance treatment
Concurrent use of complementary or alternative medicines that would confound the interpretation of toxicities and antitumor activity of the study drugs
Patients with known allergies, hypersensitivity, or intolerance to panobinostat, daratumumab, or bortezomib
Unacceptable respiratory risk factors defined by any one of the following criteria:
Chronic obstructive pulmonary disease (COPD) with a forced expiratory volume in 1 second (FEV1) less than 50% of predicted normal
Moderate or severe persistent asthma within the past 2 years, or currently has uncontrolled asthma of any classification
Unacceptable cardiac risk factors defined by any of the following criteria:
Patients with congenital long QT syndrome
Any history of ventricular fibrillation or torsade de pointes
Bradycardia defined as heart rate (HR) < 50 beats per minute (bpm)
Left ventricular ejection fraction < 30%
Patients who have received targeted or investigational agents within 2 weeks or within 5 half-lives of the agent and active metabolites (whichever is shorter) and who have not recovered from side effects of those therapies
Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from the side-effects of surgery
Patients with known positivity for human immunodeficiency virus (HIV) or hepatitis C; baseline testing for HIV and hepatitis C is not required
Patients with active hepatitis B (defined as hepatitis B virus surface antigen positive [HBsAg+]); HBV screening is required prior to beginning therapy
Patients with prior hepatitis B vaccine are permitted (defined as hepatitis B virus surface antigen negative [HBsAg-], hepatitis B virus surface antibody positive [Anti-HBs+], hepatitis B virus core antibody negative (Anti-HBc-])
Non-active hepatitis B (HBsAg-, Anti-HBs+, hepatitis B virus core antibody positive [Anti-HBc+]) may only be enrolled following approval by the sponsor after consideration of risk of reactivation (additional screening and monitoring for hepatitis B and consultation with a liver disease specialist may be required)
Patients with a history of another primary malignancy that is currently clinically significant or currently requires active intervention, other than non-melanoma skin cancer and carcinoma in situ of the cervix, should not be enrolled
Patients are not considered to have a "currently active" malignancy if they have completed therapy for a prior malignancy, are disease free from a prior malignancy for >= 3 yrs, and are considered by their physician to be less than 30% risk of relapse
Patients with a history of gastrointestinal surgery or other procedure that might, in the opinion of the investigator(s), interfere with the absorption or swallowing of the study drugs
Patients with any significant history of non-compliance to medical regimens or unwilling or unable to comply with the instructions given to them by the study staff
Any other medical condition, including mental illness or substance abuse, deemed by the investigator(s) to likely interfere with the patient's ability to sign informed consent, cooperate and participate in the study, or interfere with the interpretation of the results
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There is 1 Location for this study
Columbus Ohio, 43210, United States
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