Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

Inclusion criteria:

Patients with hematological malignances with an expression of CD70 in the pre-enrollment tumor sample ≥ 10% measured by immunohistochemistry or flow cytometry.
Patients must meet diseases specific eligibility criteria (see below)
Patients at least 3 weeks from last cytotoxic chemotherapy at the time of starting lymphodepleting chemotherapy. Patients may continue tyrosine kinase inhibitors or other targeted therapies until at least three days prior to administration of lymphodepleting chemotherapy.
Localized radiotherapy to one or more disease sites are allowed prior the infusion provided that there are additional disease sites that are not irradiated
Karnofsky Performance Scale > 50%.

Adequate organ function:

Renal: Serum creatinine /= 30 ml/min/1.73 m2.
Hepatic: ALT/AST Cardiac: Cardiac ejection fraction >/= 50%, no clinically significant pericardial effusion as determined by an ECHO or MUGA, and no uncontrolled arrhythmias or symptomatic cardiac disease.
Pulmonary: No clinically significant, , pleural effusion (per PI discretion), baseline oxygen saturation > 92% on room air and adequate pulmonary function with FEV1, FVC and DLCO (corrected for Hgb) >50%.
Able to provide written informed consent.
18-75 years of age.
Weight ≥40 kg
All participants who are able to have children must practice effective birth control while on study and up to 3 months post completion of study therapy. Acceptable forms of birth control for female patients include: hormonal birth control, intrauterine device, diaphragm with spermicide, condom with spermicide, or abstinence, for the length of the study. If the participant is a female and becomes pregnant or suspects pregnancy, she must immediately notify her doctor. If the participant becomes pregnant during this study, she will be taken off this study. Men who are able to have children must use effective birth control while on the study. If the male participant fathers a child or suspects that he has fathered a child while on the study, he must immediately notify his doctor.
Signed consent to long-term follow-up protocol PA17-0483.

Exclusion criteria:

Positive beta HCG in female of child-bearing potential defined as not postmenopausal for 24 months or no previous surgical sterilization or lactating females.
Presence of clinically significant Grade 3 or greater toxicity from the previous treatment, as determined by PI.
Presence of uncontrolled fungal, bacterial, viral, or other infection not responding to appropriate therapy.
HIV with detectable viral load
Presence of active neurological disorder(s).
Active autoimmune disease within 12 months of enrollment
Amyloidosis or POEMS syndrome
Active cerebral or meningeal involvement by the malignancy
Active (defined as requiring therapy) acute or chronic GVHD
Any other malignancy known to be active, except for treated cervical intra-epithelial neoplasia and non-melanoma skin cancer.
Presence of any other serious medical condition that may endanger the patient at investigator discretion.
Major surgery <4 weeks prior to first dose of the preparatory chemotherapy
Allogeneic SCT or DLI <12 weeks prior to first dose of preparatory chemotherapy
Concomitant use of other investigational agents.
Concomitant use of other anti-cancer agents.
Patients receiving systemic steroid therapy at time of enrollment (physiological substitutive doses are allowed), or have received antithymocyte globulin or lymphocyte immune globulin within 14 days of enrollment or alemtuzumab within 28 days of enrollment.
Patients receiving immunosuppressive therapy