Multiple Myeloma Clinical Trial

Safety, Activity and Cell Kinetics of CYAD-211 in Patients With Relapsed or Refractory Multiple Myeloma

Summary

The purpose of the IMMUNICY-1 study is to assess the safety, activity and cell kinetics of CYAD-211 in adults with relapsed or refractory multiple myeloma after a lymphodepletion regimen with fludarabine and/or cyclophosphamide

View Full Description

Full Description

This study aims to determine the recommended dose of the allogeneic CYAD-211 (anti-BCMA CAR-T) cells after a non-myeloablative preconditioning chemotherapy in multiple myeloma (MM) patients with relapsed or refractory disease.

View Eligibility Criteria

Eligibility Criteria

Documented diagnosis of MM with relapsed or refractory disease to at least two prior MM treatment regimens which should include exposure to IMiD and PIs either alone or in combination.
Presence of measurable disease as per International Myeloma Working Group (IMWG) Response Criteria
Eastern Cooperative Oncology Group (ECOG) below or equal 2
Adequate hematologic, renal, hepatic, pulmonary, and cardiac function

Exclusion Criteria:

History or presence of clinically relevant central nervous system (CNS) tumor involvement.
Autologous stem cell transplant within 12 weeks of registration or an allogeneic stem cell transplant within 6 months of starting study treatment.
Any investigational agent within 3 weeks prior to the initiation of the non-myeloablative preconditioning chemotherapy).
Prior systemic therapy for MM within 14 days prior to the initiation of the non-myeloablative preconditioning chemotherapy.
Prior treatment with any BCMA-targeted therapy and which has not achieved at least a partial response.

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

18

Study ID:

NCT04613557

Recruitment Status:

Active, not recruiting

Sponsor:

Celyad Oncology SA

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 5 Locations for this study

See Locations Near You

H. Lee Moffitt Cancer Center
Tampa Florida, 33612, United States
Nyu Langone Hospitals
New York New York, 10016, United States
Universitair Ziekenhuis Antwerpen
Antwerp , 2650, Belgium
Institut Jules Bordet
Brussels , 1000, Belgium
AZ DELTA
Roeselare , 8800, Belgium

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

18

Study ID:

NCT04613557

Recruitment Status:

Active, not recruiting

Sponsor:


Celyad Oncology SA

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.