Multiple Myeloma Clinical Trial

Study of BMS-986393 a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

Summary

The purpose of this study is to evaluate the effectiveness and safety of BMS-986393 in participants with relapsed or refractory multiple myeloma.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria

Documented diagnosis of multiple Mmyeloma (MM) as per International Myeloma Working Group (IMWG) criteria.
Received at least 4 classes of MM treatment [including immunomodulatory drug (IMiD), proteasome inhibitor (PI), anti CD38 mAb, and anti-B cell maturation antigen (BCMA) therapy], and at least 3 prior lines of therapy (LOT).
Documented disease progression during or after their last anti-myeloma regimen as per IMWG.
Participants must have measurable disease during screening.
Have measurable disease during screening.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

Exclusion Criteria

Active or history of central nervous system involvement with MM.
Active systemic fungal, bacterial, viral, or other infection despite appropriate anti-infective treatment at the time of leukapheresis.
Received any prior therapy directed at G protein-coupled receptor class C, group 5, member D (GPRC5D) or has received other prior treatment for MM without the required washout prior to leukapheresis.
Other protocol-defined Inclusion/Exclusion criteria apply.

Study is for people with:

Multiple Myeloma

Phase:

Phase 2

Estimated Enrollment:

150

Study ID:

NCT06297226

Recruitment Status:

Recruiting

Sponsor:

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

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There are 36 Locations for this study

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Local Institution - 0001
Birmingham Alabama, 35294, United States More Info
Site 0001
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Local Institution - 0025
Gilbert Arizona, 85234, United States More Info
Site 0025
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Local Institution - 0037
Little Rock Arkansas, 72205, United States More Info
Site 0037
Contact
UCLA Hematology/Oncology - Westwood (Building 200 Suite 214)
Los Angeles California, 90095, United States More Info
Sarah Larson, Site 0028
Contact
310-829-5471
Local Institution - 0018
San Francisco California, 94143, United States More Info
Site 0018
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Colorado Blood Cancer Institute
Denver Colorado, 80218, United States More Info
Tara Gregory, Site 0049
Contact
720-754-4800
Local Institution - 0045
Miami Florida, 33176, United States More Info
Site 0045
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Local Institution - 0029
Tampa Florida, 33612, United States More Info
Site 0029
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Local Institution - 0009
Atlanta Georgia, 30322, United States More Info
Site 0009
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Local Institution - 0004
Atlanta Georgia, 30342, United States More Info
Site 0004
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Local Institution - 0005
Chicago Illinois, 60611, United States More Info
Site 0005
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Local Institution - 0056
Chicago Illinois, 60637, United States More Info
Site 0056
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Local Institution - 0019
Iowa City Iowa, 52242, United States More Info
Site 0019
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Local Institution - 0016
Kansas City Kansas, 66160, United States More Info
Site 0016
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Local Institution - 0026
Saint Matthews Kentucky, 40207, United States More Info
Site 0026
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Local Institution - 0039
Boston Massachusetts, 02114, United States More Info
Site 0039
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Local Institution - 0036
Boston Massachusetts, 02215, United States More Info
Site 0036
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Local Institution - 0033
Rochester Minnesota, 55905, United States More Info
Site 0033
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Local Institution - 0010
Saint Louis Missouri, 63110, United States More Info
Site 0010
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Local Institution - 0034
New Brunswick New Jersey, 08903, United States More Info
Site 0034
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Local Institution - 0046
Buffalo New York, 14263, United States More Info
Site 0046
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Local Institution - 0002
New York New York, 10029, United States More Info
Site 0002
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Local Institution - 0003
New York New York, 10065, United States More Info
Site 0003
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Local Institution - 0031
Chapel Hill North Carolina, 27599, United States More Info
Site 0031
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Local Institution - 0054
Cincinnati Ohio, 45242, United States More Info
Site 0054
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Local Institution - 0032
Columbus Ohio, 43210, United States More Info
Site 0032
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Local Institution - 0038
Portland Oregon, 97239, United States More Info
Site 0038
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Local Institution - 0043
Nashville Tennessee, 37232, United States More Info
Site 0043
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Local Institution - 0035
Dallas Texas, 75390, United States More Info
Site 0035
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Local Institution - 0027
Houston Texas, 77030, United States More Info
Site 0027
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Local Institution - 0055
San Antonio Texas, 78229, United States More Info
Site 0055
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Local Institution - 0050
Salt Lake City Utah, 84143, United States More Info
Site 0050
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Local Institution - 0011
Seattle Washington, 98109, United States More Info
Site 0011
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Local Institution - 0015
Madison Wisconsin, 53792, United States More Info
Site 0015
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Local Institution - 0020
Calgary Alberta, T2N 4, Canada More Info
Site 0020
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Local Institution - 0021
Montréal Quebec, H4A 3, Canada More Info
Site 0021
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How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 2

Estimated Enrollment:

150

Study ID:

NCT06297226

Recruitment Status:

Recruiting

Sponsor:


Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

How clear is this clinincal trial information?

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